US2019099519A1PendingUtilityA1

Method for producing nanosurfaces with nano, micron, and/or submicron structures on a polymer

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Assignee: NANOVIS INCPriority: Jun 25, 2010Filed: Sep 28, 2018Published: Apr 4, 2019
Est. expiryJun 25, 2030(~3.9 yrs left)· nominal 20-yr term from priority
Inventors:Matthew HedrickGanesan BalasundaramChang Yao
A61L 27/50C08L 71/00B29C 59/022A61L 31/048C08G 2650/40A61L 2400/12A61L 2400/18Y10T428/24355Y10T428/2978A61L 27/10B29K 2071/00B29L 2031/7532A61F 2/0063C08G 65/46A61C 8/00A61L 17/04B29C 41/24C08F 110/06C08G 63/88A61L 31/14C08L 23/10A61L 31/06A61L 27/18A61B 17/0401A61L 17/14Y10T428/2982A61B 17/06166C08G 65/4012
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Claims

Abstract

The present invention relates to a modified polymeric material. The modified polymeric material includes a polymer having a modified surface, where the modified surface includes nano, micron, and/or submicron scale features. The present invention also relates to an implant comprising the modified polymeric material. The present invention further relates to processes for making the modified polymeric material and the implant.

Claims

exact text as granted — not AI-modified
What is claimed is: 
     
         1 . A modified polymeric material comprising a polymer having a modified surface, wherein said modified surface comprises nano, micron, and/or submicron scale features. 
     
     
         2 . The modified polymeric material according to  claim 1 , wherein the polymer is a thermoplastic polymer. 
     
     
         3 . The modified polymeric material according to  claim 2 , wherein the thermoplastic polymer is selected from the group consisting of polypropylene, polyetheretherketone (PEEK), poly lactic glycolic acid, poly lactic lactic acid, poly lactic acid, polyurethane, and the like. 
     
     
         4 . The modified polymeric material according to  claim 1 , wherein the polymer is in the form of a polymeric film, fiber, sphere, ovoid, rod, filament, monofilament, or scaffold, plug, or matrix. 
     
     
         5 . The modified polymeric material according to  claim 1 , wherein said modified polymeric material is effective to modify biological response (e.g., increased or decreased tissue or bacteria attachment), fixation (e.g., improve mechanical interface with bone), or therapeutic attachment/delivery compared to a corresponding non-modified polymeric material. 
     
     
         6 . The modified polymeric material according to  claim 5 , wherein the biological response is selected from the group consisting of protein or antibody adsorption, cell attachment, cell function, and tissue growth. 
     
     
         7 . The modified polymeric material according to  claim 5 , wherein the therapeutic is selected from the group consisting of a peptide, protein, growth factor, antibody, drug, metal, antimicrobial metal, biologic tissue, biologic agent, chemical agent, stem cell, modified cell, and the like. 
     
     
         8 . The modified polymeric material according to  claim 1  further comprising:
 a functional attachment effective to increase biological response or therapeutic attachment/delivery; and/or 
 a ceramic, metal, or another polymer integrated into the modified polymeric material or coated onto the surface of the modified polymeric material. 
 
     
     
         9 . The modified polymeric material according to  claim 8 , wherein the functional attachment is selected from the group consisting of a peptide, protein, growth factor, antibody, drug, metal, antimicrobial metal, biologic tissue, biologic agent, chemical agent, stem cell, modified cell, and the like. 
     
     
         10 . An implant comprising:
 a modified polymeric material according to  claim 1 .   
     
     
         11 . The implant according to  claim 10 , wherein the polymer is polypropylene and the implant is a hernia mesh or polymer suture. 
     
     
         12 . The implant according to  claim 10 , wherein the polymer is PEEK and the implant is a spine cage, vertebral body replacement, suture anchor, dental implant, maxillofacial implant, or the like. 
     
     
         13 . A process for preparing a modified polymeric material, said process comprising:
 providing a polymer; and   subjecting the polymer to a high vacuum treatment regimen under conditions effective to modify the surface of the polymer by introducing nano, micron, and/or submicron scale features to the surface of the polymer.   
     
     
         14 . The process according to  claim 13 , wherein the high vacuum treatment regimen comprises:
 heating the polymer at a high temperature; and/or   incubating the heat-treated polymer in a vacuum chamber under high vacuum conditions effective to modify the surface of the polymer,   wherein said heating can be at a heat range specific to the polymer and relative to the polymer's melting and crystallization temperature.   
     
     
         15 . The process according to  claim 14 , wherein said heating is carried out at a temperature of between about 300° C. and about 400° C. 
     
     
         16 . The process according to  claim 14 , wherein said heating is carried out at a temperature of about 350° C. for between about 1 and about 90 minutes. 
     
     
         17 . The process according to  claim 13 , wherein said incubating is carried out for at least 5 hours. 
     
     
         18 . The process according to  claim 13 , wherein the high vacuum treatment regimen comprises:
 subjecting the polymer to heating and simultaneous high vacuum conditions effective to modify the surface of the polymer.   
     
     
         19 . The process according to  claim 18 , wherein said subjecting comprises:
 (a) loading the polymer at a temperature of about 150° C.;   (b) applying high vacuum conditions of about 10 mTorr;   (c) increasing the temperature to about 350° C. over the course of about 1 hour;   (d) maintaining the polymer at about 350° C. at 10 mTorr for about 1 hour;   (e) decreasing the temperature to about 150° C. over the course of about 1 hour; and   (f) extracting the polymer at about 150° C.   
     
     
         20 . The process according to  claim 19  further comprising:
 storing the extracted polymer under high vacuum conditions for about 8 hours. 
 
     
     
         21 . A process for preparing a modified polymeric material, said process comprising:
 providing a polymer; and   incubating the polymer in mild heat in a vacuum chamber under high vacuum conditions effective to modify the surface of the polymer by introducing nano, micron, and/or submicron scale features to the surface of the polymer.   
     
     
         22 . The process according to  claim 21 , wherein said mild heat comprises a temperature of not more than 70° C. 
     
     
         23 . The process according to  claim 21 , wherein said incubating is carried out for between about 18 and 30 hours. 
     
     
         24 . A process for preparing a modified polymeric material, said process comprising:
 providing a polymer; and   incubating the polymer in methylene chloride in a vacuum chamber under high vacuum conditions effective to modify the surface of the polymer by introducing micron and/or submicron scale features to the surface of the polymer.   
     
     
         25 . The process according to  claim 24 , wherein said incubating is carried out for between about 18 and 30 hours. 
     
     
         26 . The process according to  claim 13  further comprising:
 applying an acid etching procedure either before or after the polymer is modified; and/or 
 integrating/coating the modified polymeric material with hydroxyapatite, titanium, calcium phosphate, and/or the like to yield a two layer or integration of the modified polymeric material and the hydroxyapatite, titanium, calcium phosphate, and the like. 
 
     
     
         27 . The process according to  claim 13 , wherein the polymer is a thermoplastic polymer. 
     
     
         28 . The process according to  claim 27 , wherein the thermoplastic polymer is selected from the group consisting of polypropylene, polyetheretherketone (PEEK), poly lactic glycolic acid, poly lactic lactic acid, poly lactic acid, polyurethane, and the like. 
     
     
         29 . The process according to  claim 13 , wherein the polymer is in the form of a polymeric film, fiber, sphere, ovoid, rod, filament, monofilament, or scaffold, plug, or matrix. 
     
     
         30 . The process according to  claim 13 , wherein said modified polymeric material is effective to modify biological response (e.g., increased or decreased tissue or bacteria attachment), fixation (e.g., improve mechanical interface with bone), or therapeutic attachment/delivery compared to a corresponding non-modified polymeric material. 
     
     
         31 . The process according to  claim 30 , wherein the biological response is selected from the group consisting of protein or antibody adsorption, cell attachment, cell function, and tissue growth. 
     
     
         32 . The process according to  claim 30 , wherein the therapeutic is selected from the group consisting of a peptide, protein, growth factor, antibody, drug, metal, antimicrobial metal, biologic tissue, biologic agent, chemical agent, stem cell, modified cell, and the like. 
     
     
         33 . The process according to  claim 13  further comprising:
 a functional attachment effective to increase biological response or therapeutic attachment/delivery; and/or 
 a ceramic, metal, or another polymer integrated into the modified polymeric material or coated onto the surface of the modified polymeric material. 
 
     
     
         34 . The process according to  claim 33 , wherein the functional attachment is selected from the group consisting of a peptide, protein, growth factor, antibody, drug, metal, antimicrobial metal, biologic tissue, biologic agent, chemical agent, stem cell, modified cell, and the like. 
     
     
         35 . A modified polymeric material produced by the process according to  claim 13 . 
     
     
         36 . A modified polymeric material according to  claim 35 , wherein said modified polymeric material can be used as, used with, or combined with biomaterials (e.g., scaffolds, bone void fillers, fusion materials autograft, Demineralized bone graft, allograft, xenograft, and the like), components, local and systemic drug delivery materials/polymers, and various other items suitable for being used or combined with the modified polymeric material. 
     
     
         37 . A modified polymeric material according to  claim 35 , wherein said modified polymeric material further includes two layer/integration aspects (e.g., integrating/coating with hydroxyapatite, titanium, calcium phosphate). 
     
     
         38 . An implant comprising a modified polymeric material produced according to the process of  claim 13 .

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