US2019100505A1PendingUtilityA1

Inhibitors of bruton's tyrosine kinase

Assignee: PHARMACYCLICS LLCPriority: Dec 5, 2013Filed: May 15, 2018Published: Apr 4, 2019
Est. expiryDec 5, 2033(~7.4 yrs left)· nominal 20-yr term from priority
A61P 35/02A61P 37/06A61P 35/00A61P 37/02A61P 43/00A61P 37/00A61P 29/00A61P 17/02A61P 19/10A61P 19/08A61P 19/00A61P 19/02A61K 31/397A61K 31/497C07D 417/14C07D 401/14C07D 401/04C07D 403/12C07D 401/12C07D 413/14A61K 31/4025C07D 471/04C07D 409/14C07D 405/14A61K 31/53A61K 31/445
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Claims

Abstract

Disclosed herein are reversible and irreversible inhibitors of Bruton's tyrosine kinase (Btk). Also disclosed are pharmaceutical compositions that include the compounds. Methods of using the Btk inhibitors are described, alone or in combination with other therapeutic agents, for the treatment of autoimmune diseases or conditions, heteroimmune diseases or conditions, cancer, including lymphoma, and inflammatory diseases or conditions.

Claims

exact text as granted — not AI-modified
1 - 20 . (canceled) 
     
     
         21 . A compound, wherein the compound is (R)-3-(1-(4-tert-butylbenzoyl)piperidin-3-ylamino)-5-(4-(morpholine-4-carbonyl)phenylamino)-1,2,4-triazine-6-carboxamide.

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