Method of decreasing dermal absorption using compositions comprising siloxane polymer

Abstract

Methods of reducing dermal penetration of at least one active ingredient in a topically applied product using compositions comprising siloxane polymers are disclosed. In some aspects, the active ingredient is an antimicrobial agent, especially benzalkonium chloride, 3-(trimethoxysilyl) propyldimethyloctadecyl ammonium chloride, and combinations thereof.

1 - 21 . (canceled) 
     
     
         22 . A topical composition comprising:
 a siloxane gel comprising a dimethicone crosspolymer;   a methylsiloxane cyclic having 4 or 5 silicon atoms;   an alkoxylated derivative of a benzyl alcohol;   an additional component selected from the group consisting of methylsiloxane cyclics having 4 and 5 silicon atoms, a trimethylsiloxy end-blocked polydimethylsiloxane, ester of aromatic alkoxylated alcohol and fatty carboxylic acid, alkoxylated derivatives of benzyl alcohol, aromatic hydrocarbons, aliphatic hydrocarbons, alcohols, aldehydes, ketones, amines, esters, ethers, glycols, glycol ethers, alkyl halides, aromatic halides, acetonitrile, nitromethane, dimethylforamide, propylene oxide, trioctyl phosphate, butyrolactone, furfural, pine oil, turpentine, m-creosol, volatile flavoring compound, volatile fragrance compound, and mixtures thereof; and   an active ingredient selected from the group consisting of:   
       
         
           
           
               
               
           
         
         and mixtures thereof, wherein R e  is (C 6 -C 22 ) alkyl and X −  is an anion selected from the group consisting of chloride, bromide, fluoride, iodide, sulfonate, and acetate. 
       
     
     
         23 . The topical composition of  claim 22 , wherein the methylsiloxane cyclic having 4 or 5 silicon atoms comprises cyclopentasiloxane. 
     
     
         24 . The topical composition of  claim 22 , wherein the alkoxylated derivative of a benzyl alcohol comprises PPG-3 benzyl ether ethylhexanoate. 
     
     
         25 . The topical composition of  claim 22 , wherein the additional component is selected from the group consisting of an essential oil, fragrance, Vitamin E, insect repellant, Green Tea Extract, and organic UV absorber. 
     
     
         26 . A method of reducing dermal penetration of an active ingredient, comprising:
 applying to a user's skin a composition comprising   a siloxane gel comprising a dimethicone crosspolymer;
 a methylsiloxane cyclic having 4 or 5 silicon atoms; 
 an alkoxylated derivative of a benzyl alcohol; 
 an additional component selected from the group consisting of methylsiloxane cyclics having 4 and 5 silicon atoms, a trimethylsiloxy end-blocked polydimethylsiloxane, ester of aromatic alkoxylated alcohol and fatty carboxylic acid, alkoxylated derivatives of benzyl alcohol, aromatic hydrocarbons, aliphatic hydrocarbons, alcohols, aldehydes, ketones, amines, esters, ethers, glycols, glycol ethers, alkyl halides, aromatic halides, acetonitrile, nitromethane, dimethylforamide, propylene oxide, trioctyl phosphate, butyrolactone, furfural, pine oil, turpentine, m-creosol, volatile flavoring compound, volatile fragrance compound, and mixtures thereof; and 
 an active ingredient selected from the group consisting of: 
   
       
         
           
           
               
               
           
         
         
           and mixtures thereof, wherein R e  is (C 6 -C 22 ) alkyl and X −  is an anion selected from the group consisting of chloride, bromide, fluoride, iodide, sulfonate, and acetate. 
         
       
     
     
         27 . The method of  claim 26 , further comprising:
 topically applying said composition to the skin of a user;   drying said topically applied composition;   topically reapplying said composition to the skin of said user at least one time; and   drying said topically reapplied composition.   
     
     
         28 . The method of  claim 26 , wherein the methylsiloxane cyclic having 4 or 5 silicon atoms comprises cyclopentasiloxane. 
     
     
         29 . The method of  claim 26 , wherein the alkoxylated derivative of a benzyl alcohol comprises PPG-3 benzyl ether ethylhexanoate. 
     
     
         30 . The method of  claim 26 , wherein the additional component is selected from the group consisting of essential oil, fragrance, Vitamin E, insect repellant, Green Tea Extract, and organic UV absorber. 
     
     
         31 . The method of  claim 26 , wherein the composition is reapplied at least three times in a one hour period. 
     
     
         32 . The method of  claim 26 , wherein the composition is reapplied at least three times in a four hour period. 
     
     
         33 . The method of  claim 26 , wherein the composition is reapplied at least seven times in an eight hour period. 
     
     
         34 . The method of  claim 26 , wherein the topical composition is reapplied at least 100 times in an eight hour period. 
     
     
         35 . The method of  claim 26 , wherein the topical composition is reapplied at least 100 times in a twelve hour period. 
     
     
         36 . The method of  claim 26 , wherein said user washes said skin with an aqueous-based cleanser before said applying step; before any one said reapplying steps; or any combination of steps thereof.