US2019106431A1PendingUtilityA1
New stable salt of 5,10-methylene-(6r)-tetrahydrofolic acid
Est. expiryAug 14, 2033(~7.1 yrs left)· nominal 20-yr term from priority
A61P 43/00A61P 35/00C07D 475/04A61K 31/519C07D 487/14A61K 9/19C07B 2200/13A61K 9/20A61K 2300/00A61K 45/06A61K 9/0019A61K 9/48C07D 475/14C07D 475/12A61K 47/12A61K 47/02
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Claims
Abstract
The present invention is directed towards the hemisulfate salt of 5,10-methylene-(6R)-tetrahydrofolic acid, preferably in substantially crystalline form, as well as pharmaceutical compositions and uses thereof in therapy, preferably chemotherapy.
Claims
exact text as granted — not AI-modified1 - 17 . (canceled)
18 . A method for the prevention of cancer or for controlling cancer comprising administering a hemisulfate salt of 5,10-methylene-(6R)-tetrahydrofolic acid to a subject in need of such treatment.
19 . A hemisulfate salt of 5,10-methylene-(6R)-tetrahydrofolic acid, which is in a form readily administrable after quick dissolution of said active agent in a pharmaceutically acceptable carrier.
20 . The use of a hemisulfate salt of 5,10-methylene-(6R)-tetrahydrofolic acid according to claim 19 in medical treatment, like in chemotherapy.
21 . A method according to claim 18 , which is for preventing cancer.
22 . A method for preventing rectal cancer according to claim 18 , comprising administering the hemisulfate salt of 5,10-methylene-(6R)-tetrahydrofolic acid in conjunction with a chemotherapeutic agent in an effective amount to a subject in need of such treatment.
23 . The hemisulfate salt of 5,10-methylene-(6R)-tetrahydrofolic acid according to claim 19 , which is in a flavored drink.Join the waitlist — get patent alerts
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