Devices and methods for treating acute kidney injury

Abstract

A catheter devices/systems and methods therefrom are described herein for treating acute kidney injury, especially the contrast-induced acute kidney injury wherein the devices may prevent the contrast dyes from entering into kidney and/or facilitate blood flow of kidney by said catheter system.

What is claimed is: 
     
         1 . A method of partially occluding a blood vessel in a subject, the method comprising:
 positioning a proximal portion of a catheter device comprising a catheter shaft and an occlusive element in a target area of an aorta of the subject; and   deploying the occlusive element of the catheter device to partially occlude the aorta while allowing blood flow over the catheter shaft between first and second expandable occlusive elements of the occlusion element, one or more of the first and second expandable occlusive elements being in an expanded configuration to partially occlude the aorta, wherein the first expandable member is disposed on the proximal portion and the second expandable member is disposed on the proximal portion in parallel with the first expandable member about the catheter shaft;   collapsing the occlusive element after a pre-determined period to allow fuller blood flow through the aorta to resume.   
     
     
         2 . The method of  claim 1 , wherein deploying the occlusive element of the catheter device comprises occluding an opening in the aorta to an adjacent blood vessel with the occlusive element in the expanded configuration. 
     
     
         3 . The method of  claim 2 , wherein one or more longitudinal position indication features are disposed on the occlusive element, and the method further comprising confirming occlusion of the opening in the aorta to the adjacent blood vessel by observing the appearance of the one or more longitudinal position indication features. 
     
     
         4 . The method of  claim 3 , wherein confirming occlusion of the opening in the aorta to the adjacent blood vessel comprises observing the formation of a bowed section in the one or more longitudinal position indication features. 
     
     
         5 . The method of  claim 3 , wherein the one or more longitudinal position indication features comprises one or more longitudinal radio-opaque markers and wherein the one or more position indication features are observed using x-ray imaging. 
     
     
         6 . The method of  claim 1 , wherein positioning the proximal portion of the catheter device comprises observing an orientation of an orientation element disposed on a distal portion of the catheter device and positioning the proximal portion of the catheter device in response to the observed orientation. 
     
     
         7 . The method of  claim 6 , wherein the orientation element is aligned with the occlusive element and configured to indicate the orientation of the occlusive element when positioned at the target area of the aorta adjacent an opening in the aorta to an adjacent blood vessel in the subject. 
     
     
         8 . The method of  claim 1 , wherein deploying the occlusive element comprises simultaneously expanding the first and second expandable members. 
     
     
         9 . A device for partially occluding an aorta in a subject, the device comprising:
 a catheter shaft comprising proximal portion and a distal portion; and   an occlusive element disposed on the proximal portion,   wherein the occlusive element has an expanded configuration in which, when advanced into the aorta, is sized to partially occlude the aorta while allowing blood flow over the catheter shaft, the occlusive element comprising a first expandable member disposed on the proximal portion and a second expandable member disposed on the proximal portion in parallel with the first expandable member about the catheter shaft, and the occlusive element allowing blood flow over the catheter shaft between the first and second expandable members in the expanded configuration, and   wherein the distal portion is configured to remain outside a body of the subject when the proximal portion is positioned at a target area of the aorta.   
     
     
         10 . The device of  claim 9 , wherein one or more of the first or second expandable members have an expanded configuration in which, when advanced to the target area of the blood vessel, are sized to occlude an opening in the aorta to an adjacent blood vessel while allowing blood flow over the catheter shaft. 
     
     
         11 . The device of  claim 10 , wherein the first expandable member and the second expandable member are in fluid communication with one another. 
     
     
         12 . The device of  claim 10 , wherein the first expandable member and the second expandable member are fluidly independent of one another. 
     
     
         13 . The device of  claim 10 , wherein the first expandable member and the second expandable member comprise a single balloon. 
     
     
         14 . The device of  claim 10 , wherein the first expandable member comprises a first balloon and the second expandable member comprises a second balloon. 
     
     
         15 . The device of  claim 9 , wherein the expanded configuration of the occlusive element is spherical, ellipsoidal, cylindrical, an n-sided prism, conical, pyramidal, butterfly-shaped, dumbbell-shaped, cigar-shaped, torpedo-shaped, or submarine-shaped. 
     
     
         16 . The device of  claim 9 , further comprising one or more position indication features disposed on the proximal portion of the catheter shaft adjacent the occlusive element. 
     
     
         17 . The device of  claim 16 , wherein the one or more position indication features comprises one or more radio-opaque markers. 
     
     
         18 . The device of  claim 9 , further comprising at least one longitudinal position indication feature disposed on the occlusive element. 
     
     
         19 . The device of  claim 18 , wherein the at least one longitudinal position indication feature comprises at least one longitudinal radio-opaque marker. 
     
     
         20 . The device of  claim 9 , wherein the at least one longitudinal position indication feature is configured to from at least one straightened section and a bowed section when the occlusive element has been expanded to the expanded configuration at the target area within the aorta and positioned adjacent the opening in the aorta to the adjacent blood vessel to occlude the opening, the bowed section bowing toward the opening, and wherein the at least one longitudinal position indication feature is configured to remain in a straightened configuration when the occlusive element has been expanded to the expanded configuration within the aorta but has not been positioned adjacent any blood vessel ostia. 
     
     
         21 . The device of  claim 9 , wherein the at least one longitudinal position indication feature is disposed on the occlusive element along a longitudinal axis of the occlusive element. 
     
     
         22 . The device of  claim 9 , further comprising an orientation element disposed on the distal portion of the catheter shaft, the orientation element aligned with the occlusive element and configured to indicate the orientation of the occlusive element when positioned adjacent the opening in the blood vessel to the adjacent blood vessel in the subject. 
     
     
         23 . The device of  claim 22 , wherein the orientation element comprises one or more of a visible marking, a protrusion, a wing, or a flag. 
     
     
         24 . The device of  claim 9 , wherein the occlusive element comprises one or more of a mesh braid, an expandable member, or an inflatable balloon. 
     
     
         25 . A system for partially occluding an aorta in a subject, the system comprising:
 the device of  claim 9 ; and   a time-delayed release mechanism in communication with the occlusive element of the device, wherein the time-delayed release mechanism is configured to collapse the occlusive element after a pre-determined amount of time following expansion of the occlusive element.   
     
     
         26 . The system of  claim 25 , wherein the time-delayed release mechanism comprises an energy accumulation and storage component. 
     
     
         27 . The system of  claim 26 , wherein the energy accumulation and storage component comprises a spring. 
     
     
         28 . The system of  claim 27 , wherein the energy accumulation and storage component comprises a syringe comprising a plunger, and wherein the spring is coupled to the plunger.