2-phenethenyltetrahydro isoquinolines useful as anti-hiv compounds

Abstract

This invention provides, among other things, tetrahydroisoquinolines useful for treating viral infections, pharmaceutical formulations containing such compounds, as well as methods of inhibiting the replication of a virus, such as HIV, or treating a disease, such as AIDS.

What is claimed is: 
     
         1 . A compound which is: 
       
         
           
           
               
               
           
         
         in which R 1  is H or unsubstituted alkoxy or phenyl substituted alkoxy;
 R 2  is H or CF 3  or unsubstituted alkoxy or phenyl substituted alkoxy; 
 R 3  is H or —C(O)OR 4  or —C(O)R 4  or —C(O)NR 4 R 5  
 wherein R 4  and R 5  are independently selected from unsubstituted alkyl, unsubstituted phenyl, or unsubstituted pyridinyl; 
 
 A is substituted or unsubstituted phenyl, 
 
         or a hydrate, solvate, or salt thereof. 
       
     
     
         2 . The compound of  claim 1 , which is: 
       
         
           
           
               
               
           
         
       
       or a hydrate, solvate, or salt thereof. 
     
     
         3 . The compound of  claim 1 , which is: 
       
         
           
           
               
               
           
         
       
       or a hydrate, solvate, or salt thereof. 
     
     
         4 . The compound of  claim 1 , which is: 
       
         
           
           
               
               
           
         
       
       or a hydrate, solvate, or salt thereof. 
     
     
         5 . The compound of  claim 1 , which is: 
       
         
           
           
               
               
           
         
       
       or a hydrate, solvate, or salt thereof. 
     
     
         6 . A pharmaceutical formulation comprising:
 a) a compound of a preceding claim, or a pharmaceutically acceptable salt thereof; and   b) a pharmaceutically acceptable excipient.   
     
     
         7 . A method of inhibiting the replication of a virus in an animal, comprising:
 a) administering a compound or a pharmaceutical formulation of a preceding claim to the animal, wherein the animal is in need of treatment thereof thereby inhibiting the replication of the virus in an animal.   
     
     
         8 . The method of  claim 7 , wherein the virus is a member of the Orthoretroviridae family. 
     
     
         9 . The method of  claim 7 , wherein the virus is HIV. 
     
     
         10 . A method of treating a disease in an animal, comprising:
 a) administering a compound or a pharmaceutical formulation of a preceding claim to the animal, wherein the animal is in need of treatment thereof thereby treating the disease in the animal.   
     
     
         11 . The method of  claim 10 , wherein the disease is AIDS. 
     
     
         12 . The method of  claim 7 , wherein the animal is a human. 
     
     
         13 . A method of treating an HIV infection in a human, the method comprising administering to said human a therapeutically effective amount of a compound according to  claim 1 .