Nasal delivery

Abstract

A nasal delivery device for and method of delivering substance to a nasal cavity of a subject, the delivery device comprising: a nosepiece for fitting to a nostril of a subject, wherein the nosepiece comprises a tip element which includes a delivery aperture from which substance is in use delivered into the nasal cavity, and the tip element is at least in part tapered such as to be inclined to a longitudinal axis of the nosepiece, with the delivery aperture extending both laterally across the tip element and along a longitudinal extent of the tip element; a nozzle through which substance is in use delivered, preferably substantially axially to a longitudinal axis of the nosepiece, to the respective nasal cavity; and a delivery unit for delivering substance through the nozzle of the nosepiece.

1 - 81 . (canceled) 
     
     
         82 . A nosepiece for fitting to a nostril of a subject, comprising:
 a tip element which includes a delivery aperture from which a substance is in use delivered into a nasal cavity of the subject;   wherein the tip element comprises a flexible structure, and includes an outer body part formed of a flexible material and an inner body part which structurally supports the outer body part;   wherein the tip element is at least in part tapered so as to be inclined to a longitudinal axis of the nosepiece, with the delivery aperture extending both laterally across the tip element and along a longitudinal extent of the tip element in relation to the longitudinal axis of the nosepiece.   
     
     
         83 . The nosepiece of  claim 82 , wherein the tip element has an elongate lateral section which has a longer dimension in a first, sagittal direction than a second direction orthogonal to the sagittal direction, such that, when the nosepiece is inserted in the nasal cavity of the subject, the longer dimension of the tip element is configured to engage lower and upper surfaces of the nasal cavity. 
     
     
         84 . The nosepiece of  claim 83 , wherein the longer dimension of the tip element is configured to expand the nasal cavity in a sagittal plane. 
     
     
         85 . The nosepiece of  claim 83 , wherein the elongate lateral section of the tip element is substantially elliptical. 
     
     
         86 . The nosepiece of  claim 83 , wherein the elongate lateral section of the tip element is substantially rectangular. 
     
     
         87 . The nosepiece of  claim 82 , wherein the tip element extends substantially axially to the longitudinal axis of the nosepiece. 
     
     
         88 . The nosepiece of  claim 82 , wherein the delivery aperture has an asymmetric shape when viewed along the longitudinal axis of the nosepiece. 
     
     
         89 . The nosepiece of  claim 88 , wherein the delivery aperture has a narrower section adjacent a forwardmost section of the tip element and a wider section adjacent a rearwardmost section of the tip element. 
     
     
         90 . The nosepiece of  claim 89 , wherein the delivery aperture has a teardrop shape when viewed along the longitudinal axis of the nosepiece. 
     
     
         91 . The nosepiece of  claim 89 , wherein the delivery aperture has a triangular shape when viewed along the longitudinal axis of the nosepiece. 
     
     
         92 . The nosepiece of  claim 82 , further comprising a base section from which the tip element extends. 
     
     
         93 . The nosepiece of  claim 92 , wherein the tip element extends substantially axially from the base section to the longitudinal axis of the nosepiece. 
     
     
         94 . The nosepiece of  claim 92 , wherein the base section defines a shoulder that is configured to form a seal with a nare of a nostril. 
     
     
         95 . The nosepiece of  claim 82 , wherein the tip element of the nosepiece has differing lengths adjacent forwardmost and rearwardmost sections thereof. 
     
     
         96 . The nosepiece of  claim 95 , wherein a ratio of lengths of the tip element adjacent the forwardmost and rearwardmost sections thereof is less than 2:1. 
     
     
         97 . The nosepiece of  claim 95 , wherein a ratio of lengths of the tip element adjacent the forwardmost and rearwardmost sections thereof is greater than 2:1. 
     
     
         98 . The nosepiece of  claim 95 , wherein the delivery aperture comprises a substantially orthogonal-directed section adjacent the forwardmost section of the tip element. 
     
     
         99 . The nosepiece of  claim 82 , wherein the outer body part of the tip element is formed from a resilient material. 
     
     
         100 . A nasal delivery device comprising the nosepiece of  claim 82 .