Method for Diagnostics, Treatment and Prevention of Parkinson's Disease

Abstract

The present invention relates to the field of medicine and in particular to Parkinson's disease (PD). Specifically the present invention relates to methods and means for early detection of PD. The invention relates also to methods and means for treatment or prophylaxis of PD. In the method of the invention a probability of a subject developing or having Parkinson's disease (PD) is determined by measuring the relative abundances of one or multiple microbial taxa in a sample from a subject; and the probability of the subject developing or having PD is determined based on the measured abundances. The present invention provides a novel approach for the diagnostics of PD.

1 .- 13 . (canceled) 
     
     
         14 . A composition for use in treatment or prevention of Parkinson's disease (PD) in an individual, wherein the composition increases abundance of intestinal Prevotellaceae in said individual. 
     
     
         15 . The composition of  claim 14 , wherein the composition comprises live or killed microbes and optionally a pharmaceutically acceptable carrier. 
     
     
         16 . The composition of  claim 14 , wherein the composition comprises live or killed microbes and a pharmaceutically acceptable carrier. 
     
     
         17 . The composition of  claim 14 , wherein the composition comprises one or more members selected from the group consisting of probiotics, other micro-organisms, prebiotics, antibiotics, growth factors, and bacteriophages. 
     
     
         18 . The composition of  claim 14  wherein the composition comprises Prevotellaceae. 
     
     
         19 . The composition of  claim 14 , wherein the composition decreases intestinal abundance of one or more of taxa selected from the group consisting of Lactobacillaceae, Verrucomicrobiaceae, Bradyrhizobiaceae,  Clostridiales  Incertae Sedis IV, Ruminococcaceae, Lachnospiraceae, Enterobacteriaceae, Bacteroidaceae,  Alistipes, Coprococcus, Anaerotruncus , Porphyromonadaceae,  Parabacteroides, Butyricicoccus, Collinsella, Eggerthella , Coriobacteriaceae,  Sporobacterium, Actinobacteria, Blautia, Enterococcus, Acetivibrio, Allobaculum Agromonas, Firmicutes, Mahella, Phaeovibrio , Porphyromonadaceae,  Oscillibacter , and  Saccharofermentans.    
     
     
         20 . The composition of  claim 14 , wherein the composition is in the form of a food composition, pharmaceutical composition, nutraceutical, supplement or an anaerobical microbiota culture. 
     
     
         21 . A method for treatment or prevention of Parkinson's disease (P D) in an individual comprising administering to said individual a composition that increases the abundance of intestinal Prevotellaceae in said individual when administered to said individual. 
     
     
         22 . The method of  claim 21 , wherein the composition comprises live or killed microbes and optionally a pharmaceutically acceptable carrier. 
     
     
         23 . The method of  claim 21 , wherein the composition comprises one or more members selected from the group consisting of probiotics, other micro-organisms, prebiotics, antibiotics, growth factors, and bacteriophages. 
     
     
         24 . The method of  claim 21 , wherein the composition comprises Prevotellaceae. 
     
     
         25 . The method of  claim 21 , wherein the composition is a stool transplant. 
     
     
         26 . The method of  claim 25 , wherein a donor of the stool transplant is selected based on high abundance of Prevotellaceae and/or low abundance of one or more of taxa selected from the group consisting of Enterobacteriaceae, Lactobacillaceae, Ruminococcaceae, Bacteroidaceae, Lachnospiraceae, Verrucomicrobiaceae, Bradyrhizobiaceae,  Clostridiales  Incertae Sedis IV,  Alistipes, Coprococcus, Anaerotruncus , Porphyromonadaceae,  Parabacteroides, Butyricicoccus, Collinsella, Eggerthella , Coriobacteriaceae,  Sporobacterium, Actinobacteria, Blautia, Enterococcus, Acetivibrio, Allobaculum Agromonas, Firmicutes, Mahella, Phaeovibrio , Porphyromonadaceae,  Oscillibacter , and  Saccharofermentans.