Probiotic treatment of skin diseases, disorders, and infections: formulations methods and systems

Abstract

The present invention teaches compositions, methods and kits for treating skin conditions, including dandruff. In various embodiments, the compositions include an effective amount of one or more probiotic microorganism of vaginal origin and/or a fraction thereof and/or a component of the metabolome for preventing and/or treating skin disorders of the scalp.

1 . A method for reducing dandruff of the scalp in a subject in need thereof, comprising administering to the subject an effective amount of a composition comprising:
 one or more  Lactobacillus  spp. isolated from human clinical vaginal specimens;   one or more of D,L-lactic acid, L-lactic acid, or D-lactic acid; and   one or more cell lysate components of the  Lactobacillus  spp.,   
       so as to reduce dandruff in the subject. 
     
     
         2 . The method of  claim 1 , wherein the  Lactobacillus  spp. have undergone less than 6 subcultures. 
     
     
         3 . The method of  claim 1 , wherein the  Lactobacillus  spp. reduces the growth of  Malassezia  spp. 
     
     
         4 . The method of  claim 1 , wherein the  Lactobacillus  spp. inhibits the growth of  Malassezia  spp. 
     
     
         5 . The method of  claim 1 , wherein the composition further comprises butyric acid. 
     
     
         6 . The method of  claim 1 , wherein the composition is administered orally. 
     
     
         7 . The method of  claim 1 , wherein the composition is administered topically. 
     
     
         8 . The method of  claim 1 , wherein the composition is administered to the subject's skin. 
     
     
         9 . The method of  claim 1 , wherein the composition is administered to the subject's scalp. 
     
     
         10 . The method of  claim 1 , wherein the composition further comprises butyric acid, glucose and glycogen. 
     
     
         11 . The method of  claim 1 , wherein the composition further comprises butyric acid, glucose, glycogen, magnesium ascorbyl phosphate, cetyl alcohol, dimethicone, isopropyl myristate and glycerol. 
     
     
         12 . The method of  claim 1 , wherein the composition comprises butyric acid, glucose, glycogen, magnesium ascorbyl phosphate, propylene glycol, Quaternium-52 and ethanol. 
     
     
         13 . The method of  claim 1 , wherein the pH of the composition is between 3 and 6. 
     
     
         14 . The method of  claim 1 , further comprising administering one or more anti-seborrhoeic agents. 
     
     
         15 . The method of  claim 1 , wherein the composition and the anti-seborrhoeic agent are administered sequentially. 
     
     
         16 . The method of  claim 1 , wherein the composition and the anti-seborrhoeic agent are administered simultaneously.