Ready-to-use, hydrophilic, self-dispersive, fragmentable and biodegradable porous sponge matrix and a method of manufacturing thereof

Abstract

The invention relates to porous absorbent Composite Material, which may be used e.g. in the form of a plug or tampon, for instance for controlling bleeding, wound closure, prevent tissue adhesion and/or support tissue regeneration. The invention provides a hydrophilic Self-Dispersive, fragmentable and Bio-Absorbable Porous Composite foams, suitable for packing antrum or other cavities of the body, comprising of composite of polymers, which polymer preferably comprises —C(O)—O—; NH2/3+; —OH; —CH2OCH2C(O)O— groups as functional or —CH—O— (e.g. C2H4O; C6H10O5; C6H8O6); —CH—N—O— (e.g. C8H13NO5); O—C—C— (e.g. O-CH2-CH2); —C(O)N— groups in the backbone of the polymers e.g. gelatin, chitosan, collagen, alginate, polyvinyl alcohol, polyethylene glycol, keratin, cellulose.

1 - 15 . (canceled) 
     
     
         16 . A porous sponge matrix, comprising:
 a biocompatible and biodegradable polymer scaffold comprising a blend of synthetic and natural polymers as a three-dimensional scaffold polyelectrolyte complex (PEC) having vesicular micro-voids and an inner surface area larger than its outer surface area; and   at least one of an antioxidant, clotting agent, growth factor, primary cells and stem cells impregnated within the vesicular micro-voids of the three-dimensional scaffold PEC, wherein the three-dimensional scaffold PEC comprises a lyophilized and homogenized polymer formed from a sequential timed and patterned physico/chemical treatment of the synthetic and natural polymers as a polymer solution comprising polyvinyl chloride at about 5% to 15%, Gelatin at about 2% to 7% and Sodium Alginate at about 0.5% to 2%.   
     
     
         17 . The porous sponge matrix according to  claim 16 , wherein the sequential timed and patterned physico/chemical treatment of the synthetic and natural polymers as a polymer solution further comprises polyethylene glycol-200 at about 1 ml to 5 ml. 
     
     
         18 . The porous sponge matrix according to  claim 17 , wherein the sequential timed and patterned physico/chemical treatment of the synthetic and natural polymers as a polymer solution further comprises chitosan at about 0.5% to 1.0%. 
     
     
         19 . The porous sponge matrix according to  claim 16 , wherein three-dimensional scaffold PEC includes a cross-linker. 
     
     
         20 . The porous sponge matrix according to  claim 16 , wherein the at least one of an antioxidant, clotting agent, growth factor, primary cells and stem cells comprises at least one of thrombin, calcium chloride, polyphenol and tranexamic acid. 
     
     
         21 . The porous sponge matrix according to  claim 16 , wherein the three-dimensional scaffold PEC comprises a patch configuration. 
     
     
         22 . The porous sponge matrix according to  claim 16 , wherein the three-dimensional scaffold PEC comprises a plug, sheet or tampon configuration. 
     
     
         23 . A porous sponge matrix, comprising:
 a biocompatible and biodegradable polymer scaffold comprising a blend of synthetic and natural polymers as a three-dimensional scaffold polyelectrolyte complex (PEC) having vesicular micro-voids and an inner surface area larger than its outer surface area; and   at least one of an antioxidant, clotting agent, growth factor, primary cells and stem cells impregnated within the vesicular micro-voids of the three-dimensional scaffold PEC, wherein the three-dimensional scaffold PEC comprises a lyophilized and homogenized polymer formed from a sequential timed and patterned physico/chemical treatment of the synthetic and natural polymers as a polymer solution comprising polyvinyl alcohol at about 7.5%, Gelatin at about 10%, Sodium Alginate at 1%, and polyethylene glycol-200 at about 3 ml.   
     
     
         24 . The porous sponge matrix according to  claim 23 , wherein the sequential timed and patterned physico/chemical treatment of the synthetic and natural polymers as a polymer solution further comprises chitosan at about 0.75 grams. 
     
     
         25 . The porous sponge matrix according to  claim 24 , wherein the sequential timed and patterned physico/chemical treatment of the synthetic and natural polymers as a polymer solution further comprises mucilage at about 1%. 
     
     
         26 . The porous sponge matrix according to  claim 23 , wherein three-dimensional scaffold PEC includes a cross-linker. 
     
     
         27 . The porous sponge matrix according to  claim 23 , wherein the at least one of an antioxidant, clotting agent, growth factor, primary cells and stem cells comprises at least one of thrombin, calcium chloride, polyphenol and tranexamic acid. 
     
     
         28 . The porous sponge matrix according to  claim 23 , wherein the three-dimensional scaffold PEC comprises a patch configuration. 
     
     
         29 . The porous sponge matrix according to  claim 23 , wherein the three-dimensional scaffold PEC comprises a plug, sheet or tampon configuration.