Rifaximin ready-to-use suspension

Abstract

A stable, taste-masked, ready-to-use suspension comprising rifaximin dispersed in a suspension base and one or more pharmaceutically acceptable additive(s). Also provided is a process for preparing a stable, taste-masked, ready-to-use suspension of rifaximin comprising the steps of mixing rifaximin with the suspension base and further sizing the particles of rifaximin by milling the suspension to obtain a homogenously dispersed rifaximin suspension.

1 ) A stable, taste-masked, ready-to-use suspension comprising rifaximin dispersed in a suspension base and one or more pharmaceutically acceptable additive(s). 
     
     
         2 ) The stable, taste-masked, ready-to-use suspension as of  claim 1  wherein one or more pharmaceutically acceptable additive(s) is selected from flavoring agent(s), sweetening agent(s), buffering agents(s), preservative(s), suspending agents(s), antioxidant(s), wetting agent(s), dispersing agent(s), pH stabilizing agent(s), taste enhancing agent(s), antifoaming agent(s) or mixtures thereof. 
     
     
         3 ) The stable, taste-masked, ready-to-use suspension as of  claim 1  wherein the pH of the suspension is from about 2 to about 8. 
     
     
         4 ) The stable, taste-masked, ready-to-use suspension as of  claim 1  wherein the viscosity of the suspension is from about 20 to about 200 Cps. 
     
     
         5 ) A stable taste-masked, ready-to-use suspension as of  claim 1  wherein the d90 of rifaximin is less than about 40 um. 
     
     
         6 ) A process for preparing stable, taste-masked, ready-to-use suspension of rifaximin wherein the said process comprises the steps of dispersing rifaximin in the suspension base comprising one or more pharmaceutically acceptable additive(s) and further milling the suspension to obtain a homogenously dispersed rifaximin suspension.