Anti-LPS Enriched Immunoglobulin Preparation for Use in the Treatment and/or Prophylaxis of a Pathologic Disorder

Abstract

The invention relates to the use of preparations enriched with anti LPS antibodies, such as those derived from mammalian colostrum or avian eggs, and optionally further antibodies against disease-associated antigens, colostrums, milk or milk product component/s and any adjuvants for treating, delaying or preventing the progression of a pathologic disorder such as chronic liver disease, cirrhosis and any complication or disorder associated therewith. The invention further relates to combined compositions comprising a combination of anti-LPS enriched antibody preparations and antibodies recognizing at least one antigen specific for a pathologic disorder and uses thereof in the treatment of immune-related disorders.

1 .- 138 . (canceled) 
     
     
         139 . A method of treating a subject who has an inflammatory bowel disease, the method comprising:
 selecting a subject who has an inflammatory bowel disease; and   orally administering to the selected subject a therapeutically effective dose of an anti-LPS enriched immunoglobulin preparation derived from colostrum.   
     
     
         140 . The method of  claim 139 , wherein the subject has ulcerative colitis or Crohn's disease. 
     
     
         141 . The method of  claim 139 , wherein the anti-LPS immunoglobulin-enriched preparation is prepared by immunizing a cow with LPS comprising O6, O8, O15, O25, O27, O63, O78, O114, O115, O128, O148, O153, and O159. 
     
     
         142 . The method of  claim 139 , wherein the anti-LPS immunoglobulin-enriched preparation is administered at a dose of 100 mg to 2000 mg per day. 
     
     
         143 . The method of  claim 142 , wherein the anti-LPS immunoglobulin-enriched preparation is administered at a dose of 1800 mg per day. 
     
     
         144 . The method of  claim 139 , wherein the colostrum is bovine colostrum. 
     
     
         145 . The method of  claim 139 , wherein the colostrum is freeze-dried colostrum.