Medical Device For Analyte Monitoring And Drug Delivery

Abstract

The invention relates to an ingestible, implantable or wearable medical device comprising a microarray which comprises a bioactive agent capable of interacting with a disease marker biological analyte; a reservoir which comprises at least one therapeutic agent and is capable of releasing the therapeutic agent(s) from the medical device; and a plurality of microchips comprising a microarray scanning device capable of obtaining physical parameter data of an interaction between the disease marker biological analyte with the bioactive agent; a biometric recognition device capable of comparing the physical parameter data with an analyte interaction profile; optionally a therapeutic agent releasing device capable of controlling release of the therapeutic agent from the reservoirs; an interface device capable of facilitating communications between the microarray scanning device, biometric recognition device and the therapeutic agent releasing device; and an energy source to power the medical device. Specifically, the invention relates to a medical device capable of detecting an analyte in a bodily fluid comprising at least one microneedle capable of obtaining a sample of a bodily fluid, a first microchannel through which the sample flows and is in fluid communication with the at least one microneedle, a second microchannel in fluid communication with the first microchannel, through which a buffer flows, wherein the second channel comprises a microarray with a bioactive agent, a microarray scanning device to detect an interaction between the bioactive agent and the analyte in the bodily fluid; and an interface device.

1 - 23 . (canceled) 
     
     
         24 . An ingestible medical device, comprising:
 a microchip enclosed in the ingestible medical device, the microchip comprising an interface device that is configured to wirelessly transmit a signal that is generated upon interaction of the device with gastric fluid to an external device located outside the subject, and is configured to transmit a physiological condition of the subject and   a biocompatible coating covering at least a portion of the ingestible medical device, wherein a portion of the coating comprises a cellulosic polymer, and wherein gastric fluid is drawn into and released from the ingestible medical device through pores in said portion of the coating,   wherein in response to being ingested by a subject, the device is configured to interact with a gastric fluid, and   wherein the device is configured to measure the physiological condition of the subject.   
     
     
         25 . A method of detecting an interaction if of an ingestible medical device with a gastric fluid comprising:
 administering an ingestible medical device to a subject, wherein the ingestible medical device comprises:   a microchip enclosed in said ingestible medical device,   wherein said medical device is configured to interact with the gastric fluid when ingested by the subject; said microchip comprising an interface device that is configured to wirelessly transmit to an external device located outside the subject a signal that is generated upon interaction of the device with the gastric fluid,   a biocompatible coating covering at least a portion of the medical device, wherein a portion of the coating comprises a cellulosic polymer, and   wherein gastric fluid is drawn into and released from the medical device through pores in said portion of the coating,   operating the ingestible medical device to transmit the signal upon interaction of the device with the gastric fluid.