Compositions comprising dead sea water and polysaccharides and uses thereof as skin protectants

Abstract

Provided are compositions including at least one Dead Sea extract and at least one polysaccharide, wherein the repeating unit of said polysaccharide is a tetrasaccharide consisting of two D-glucose residues, one L-fucose residue and one D-glucuronic acid residue. Further provided are formulations including the compositions and their uses as skin protectants against pollution.

1 .- 70 . (canceled) 
     
     
         71 . A composition comprising at least one Dead Sea extract and at least one polysaccharide, wherein the repeating unit of said polysaccharide is a tetrasaccharide consisting of two D-glucose residues, one L-fucose residue and one D-glucuronic acid residue. 
     
     
         72 . The composition according to  claim 71 , wherein said polysaccharide is an anionic polysaccharide and/or a branched polysaccharide. 
     
     
         73 . The composition according to  claim 71 , wherein the repeating unit of said polysaccharide has the following Formula (I): 
       
         
           
           
               
               
           
         
         wherein D-GlcpA designates a D-glucuronic acid residue, L-Fucp designates a L-fucose residue and D-Glcp designates a D-glucose residue. 
       
     
     
         74 . The composition according to  claim 71 , wherein said polysaccharide is Biosaccharide gum-4 e.g., the commercially available product Pollustop® and/or the commercially available product Glycofilm®. 
     
     
         75 . The composition according to  claim 71 , wherein said polysaccharide is present in said composition at a concentration of between about 0.5% (w/w) to about 5% (w/w) e.g., at a concentration of about 5% (w/w). 
     
     
         76 . The composition according to  claim 71 , wherein said Dead Sea extract is selected from one or more natural material, in the form of a single material or a mixture of natural materials obtained from the waters of the Dead Sea and/or the mud surrounding the Dead Sea and/or the soil bed of the Dead Sea. 
     
     
         77 . The composition according to  claim 71 , wherein said Dead Sea extract is Dead Sea water e.g., the commercially available product Maris Sal. 
     
     
         78 . The composition according to  claim 71 , wherein said Dead Sea extract is present in said composition at a concentration of between about 0.1% to about 2.5% (w/w). 
     
     
         79 . The composition according to  claim 71 , wherein said polysaccharide is present in said composition at a concentration of about 5% (w/w) and wherein said Dead Sea extract is present in said composition at a concentration of between about 0.25% to about 0.8% (w/w) of the total weight of the composition. 
     
     
         80 . The composition according to  claim 71 , being a topical composition e.g., a leave-on topical composition and a rinse off topical composition. 
     
     
         81 . The composition according to  claim 71 , being comprised within a patch and/or being in a form selected from a film, a serum, a lotion, an ointment, a gel, a cream, a water in oil or oil in water emulsion, a shampoo, a moisturizer, a sunscreen, a cream, a stick, a spray, an aerosol, foam, a paste, a mousse, a solid, semi-solid, or a liquid make-up, a foundation, and a make-up. 
     
     
         82 . The composition according to  claim 71 , formulated as a dermatological formulation e.g., a pharmaceutical or a cosmetic formulation, optionally further comprising at least one drug molecule. 
     
     
         83 . A method for protecting the skin of a subject against at least one pollutant comprising applying to the skin of said subject a composition according to  claim 71 . 
     
     
         84 . The method according to  claim 83 , wherein said at least one pollutant is selected from the group consisting of particulate matter/s, heavy metal/s, carbon particle/s, smoke, dirt, dust, organic compound/s, polyaromatic hydrocarbon/s, gas/s, ozone, peroxyacetyl nitrate/s, smog and any combination thereof. 
     
     
         85 . The method according to  claim 83 , wherein said heavy metal is selected from the group consisting of As, Cd, Co, Cr, Ni, Pb, Sr, Sb and any combination thereof. 
     
     
         86 . The method according to  claim 83 , wherein said gas is selected from the group consisting of CO 2 , CO, SO 2 , NO, NO 2 , N 2 O, N 2 O 2 , N 2 O 3 , N 2 O 4 , N 2 O 5 , light molecular weight hydrocarbons and any combination thereof. 
     
     
         87 . The method according to  claim 83 , wherein said at least one pollutant is ozone. 
     
     
         88 . A method for the treatment and/or prevention of at least one disease or disorder of the skin of a subject comprising applying to the skin of said subject a composition according to  claim 71 , wherein said disease or disorder being associate with and/or being induced by pollution. 
     
     
         89 . The method according to  claim 88 , wherein said disease or disorder of the skin is related to inflammation and/or oxidation. 
     
     
         90 . The method according to  claim 88 , wherein said disease or disorder of the skin is selected from the group consisting of dry skin, sensitive skin irritated skin, diabetic skin, photo damaged skin, psoriatic skin, atopic skin, contact dermatitis skin, rosacea skin, acne, premature aged skin, accelerated skin aging, skin abnormal pigmentation, acne, cancer and any combinations thereof.