Compositions and methods for increasing efficiency of cardiac metabolism

Abstract

Compositions and methods for increasing efficiency of cardiac metabolism are provided.

1 - 26 . (canceled) 
     
     
         27 . A compound represented by formula (VI): 
       
         
           
           
               
               
           
         
       
       wherein:
 at least one of positions A, B, C, D, E, and F is substituted with —(CH 2 CH 2 O) n H and n=1-15. 
 
     
     
         28 . The compound of  claim 27 , wherein position F is substituted. 
     
     
         29 . The compound of  claim 28 , wherein positions B, C, D, and E are not substituted. 
     
     
         30 . The compound of  claim 27 , wherein n=1-5. 
     
     
         31 . The compound of  claim 30 , wherein n=1. 
     
     
         32 . The compound of  claim 27 , wherein the compound is represented by formula (IX): 
       
         
           
           
               
               
           
         
       
     
     
         33 . A method of treating a disease, disorder, or condition in a subject, the method comprising providing to the subject a compound represented by formula (VI): 
       
         
           
           
               
               
           
         
       
       wherein:
 at least one of positions A, B, C, D, E, and F is substituted with —(CH 2 CH 2 O) n H and n=1-15. 
 
     
     
         34 . The method of  claim 33 , wherein position F is substituted. 
     
     
         35 . The method of  claim 34 , wherein positions B, C, D, and E are not substituted. 
     
     
         36 . The method of  claim 33 , wherein n=1-5. 
     
     
         37 . The method of  claim 36 , wherein n=1. 
     
     
         38 . The method of  claim 33 , wherein the compound is represented by formula (IX): 
       
         
           
           
               
               
           
         
       
     
     
         39 . The method of  claim 33 , wherein the disease, disorder, or condition comprises impaired mitochondrial function or altered fatty acid oxidation. 
     
     
         40 . The method of  claim 39 , wherein the disease, disorder, or condition is selected from the group consisting of heart failure, ischemic heart disease, diabetic cardiomyopathy, rheumatic heart disease, valvular heart disease, aneurysm, atherosclerosis, high blood pressure, peripheral arterial disease, angina, atherosclerosis, coronary artery disease, coronary heart disease, heart attack, atherosclerosis, cerebral vascular disease, stroke, transient ischemic attacks, atherosclerosis, cardiomyopathy, pericardial disease, valvular heart disease, and congenital heart disease.