Method of inhibiting quorum sensing using d-galactose

Abstract

Provided are a use of D-galactose in inhibition of quorum sensing and/or in prevention and/or treatment of oral bacterial diseases; in particular, a composition for inhibiting quorum sensing and a composition for preventing and/or treating oral bacterial diseases, the composition comprising D-galactose, and a method of inhibiting quorum sensing and a method of preventing and/or treating oral bacterial diseases, the method comprising administering D-galactose.

What is claimed is: 
     
         1 . A method of inhibiting quorum sensing of oral disease-causing bacteria, the method comprising administering a pharmaceutically effective amount of D-galactose to a subject in need of inhibition of quorum sensing of oral disease-causing bacteria, wherein the oral disease-causing bacteria is one or more selected from the group consisting of bacteria belonging to the genus  Tannerella.    
     
     
         2 . The method of  claim 1 , wherein the oral disease-causing bacteria is  Tannerella  forsythia. 
     
     
         3 . The method of  claim 1 , wherein quorum sensing of non-pathogenic normal oral flora is not inhibited. 
     
     
         4 . A method of inhibiting biofilm formation of oral disease-causing bacteria, the method comprising administering a pharmaceutically effective amount of D-galactose to a subject in need of inhibition of biofilm formation of oral disease-causing bacteria, wherein the oral disease-causing bacteria is one or more selected from the group consisting of bacteria belonging to the genus  Tannerella.    
     
     
         5 . The method of  claim 4 , wherein the oral disease-causing bacteria is  Tannerella  forsythia. 
     
     
         6 . The method of  claim 4 , wherein biofilm formation of non-pathogenic normal oral flora is not inhibited. 
     
     
         7 . A method of preventing, treating, or ameliorating an oral bacterial disease, the method comprising administering a pharmaceutically effective amount of D-galactose to a subject in need of preventing, treating, or ameliorating the oral bacterial disease, wherein the oral disease-causing bacteria is one or more selected from the group consisting of bacteria belonging to the genus  Tannerella.    
     
     
         8 . The method of  claim 7 , wherein the oral disease-causing bacteria is  Tannerella  forsythia. 
     
     
         9 . The method of  claim 7 , wherein the oral bacterial disease is a periodontal disease.