US2019225587A1PendingUtilityA1
Indazolyl- and indolyl-benzamide derivatives
Est. expirySep 11, 2034(~8.2 yrs left)· nominal 20-yr term from priority
Inventors:Philip F. Hughes
A61P 35/00A61P 31/18A61P 31/14A61P 31/20A61P 29/00A61P 31/00C07D 231/56C07D 231/54C07D 405/12C07D 409/12C07D 401/12A61P 19/02C07D 403/12
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Claims
Abstract
useful in the treatment and/or prevention of diseases and/or conditions related to cell proliferation, such as cancer, infection, inflammation and inflammation-associated disorders, and conditions associated with angiogenesis.
Claims
exact text as granted — not AI-modified1 . A compound of the formula:
or pharmaceutically acceptable salts thereof, wherein
bond “ ” is a single or a double bond;
R 3 is hydrogen, halogen, cyano, —C(O)OH, —C(O)—O(C 1 -C 6 alkyl), —N(R N ) 2 , C 1 -C 6 alkyl, C 1 -C 6 alkoxy, C 1 -C 6 haloalkyl, C 3 -C 7 cycloalkyl, aryl, or heteroaryl, wherein;
each alkyl, cycloalkyl, aryl, and heteroaryl group is optionally substituted with from 1-4 groups that are independently C 1 -C 6 alkyl, C 1 -C 6 alkoxy, halogen, hydroxy, amino, mono- or di-(C 1 -C 6 ) alkylamino, halo(C 1 -C 6 )alkyl, halo(C 1 -C 6 )alkoxy, or carboxamide; and each R N is independently hydrogen or —C 1 -C 6 alkyl-;
R 4 and R 5 are independently hydrogen or halogen;
R 6 is halogen or a C 1 -C 15 alkyl group where up to six of the carbon atoms in said alkyl group are optionally replaced independently by R 22 , carbonyl, ethenyl, ethynyl or a moiety selected from N, O, S, SO 2 , or SO, with the proviso that two O atoms, two S atoms, or an O and S atom are not immediately adjacent each other, wherein
R 22 is heteroaryl, aryl, saturated or unsaturated C 3 -C 10 cycloalkyl, or saturated or unsaturated C 2 -C 10 heterocycloalkyl, wherein each aryl, heteroaryl, saturated or unsaturated cycloalkyl, or saturated or unsaturated heterocycloalkyl, independently, is optionally substituted with at least one group, which independently is hydroxy, halo, amino, cyano, carboxy, carboxamido, nitro, oxo, —S—(C 1 -C 6 )alkyl, —SO 2 —(C 1 -C 6 )alkyl, —SO 2 -aryl, —SO—(C 1 -C 6 )alkyl, —SO-aryl, —SO 2 NH 2 , —SO 2 NH—(C 1 -C 6 )alkyl, —SO 2 NH-aryl, (C 1 -C 6 )alkoxy, or mono- or di-(C 1 -C 10 )alkylamino; and wherein each is optionally fused to a C 6 -C 10 aryl group, C 5 -C 8 saturated cyclic group, or a C 5 -C 10 heterocycloalkyl group;
and wherein R 6 group is optionally substituted at any available position independently with C 1 -C 10 alkyl, C 1 -C 10 haloalkyl, C 2 -C 10 alkenyl, C 2 -C 10 alkynyl, hydroxy, carboxy, carboxamido, oxo, halo, amino, cyano, nitro, —SH, —S—(C 1 -C 6 )alkyl, —SO 2 —(C 1 -C 6 )alkyl, —SO 2 NH 2 , —SO 2 NH—(C 1 -C 6 )alkyl, —SO 2 NH-aryl, —SO 2 -aryl, —SO—(C 1 -C 6 )alkyl, —SO 2 -aryl, C 1 -C 6 alkoxy, C 2 -C 10 alkenyloxy, C 2 -C 10 alkynyloxy, mono- or di-(C 1 -C 10 )alkylamino, —OC 1 -C 10 alkyl-Z, or R 23 , wherein
Z is OR 31 or —N(R 30 ) 2 , wherein
each R 30 is independently hydrogen or C 1 -C 6 alkyl, or N(R 30 ) 2 represents pyrrolidinyl, piperidinyl, piperazinyl, azepanyl, 1,3- or 1,4-diazepanyl, or morpholinyl, each of which is optionally substituted with hydroxy, amino, aminoalkyl, C 1 -C 6 alkyl, mono- or di(C 1 -C 6 )alkylamino, C 1 -C 6 alkoxy, or halogen;
R 31 is hydrogen, C 1 -C 10 alkyl, C 2 -C 10 alkenyl, C 2 -C 10 alkynyl, aryl, heteroaryl, or C 1 -C 6 acyl;
R 23 is heteroaryl, aryl, saturated or unsaturated C 5 -C 10 cycloalkyl, or saturated or unsaturated C 5 -C 10 heterocycloalkyl, and each is optionally substituted at least one group which is independently hydroxy, oxo, halo, amino, cyano, nitro, —SH, —S—(C 1 -C 6 )alkyl, —SO 2 —(C 1 -C 6 )alkyl, —SO 2 -aryl, —SO—(C 1 -C 6 )alkyl, —SO-aryl, —SO 2 NH 2 , —SO 2 NH—(C 1 -C 6 )alkyl, —SO 2 NH-aryl, C 1 -C 6 alkoxy, or mono- or di-(C 1 -C 10 )alkylamino;
R 9 and R 10 are independently hydrogen or C 1 -C 8 alkyl; or R 9 and R 10 taken together with the carbon atom to which they are attached form C 3 -C 8 cycloalkyl;
R 11 is hydrogen, hydroxy, C 1 -C 10 alkyl, C 2 -C 10 alkenyl, C 2 -C 10 alkynyl, C 1 -C 10 haloalkyl, C 1 -C 10 alkoxy, mono- or di-(C 1 -C 10 )alkylamino, C 1 -C 10 alkoxy(C 1 -C 10 )alkyl, hydroxy(C 1 -C 10 ) alkoxy, or amino(C 1 -C 10 ) alkoxy;
R 41 is cyano or a group of the formula
wherein
R 1 and R 2 are independently H, hydroxy, C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, heteroaryl, aryl, C 3 -C 8 cycloalkyl, heterocycloalkyl, wherein
each alkyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl group is optionally substituted with from 1-4 groups that are independently C 1 -C 6 alkyl, C 1 -C 6 alkoxy, halogen, hydroxy, amino, mono- or di-(C 1 -C 6 ) alkylamino, nitro, halo(C 1 -C 6 )alkyl, halo(C 1 -C 6 )alkoxy, or carboxamide;
X 4 is oxygen or sulfur;
X is N or CR C ; and
Y is N or CR C ;
each R C is independently is hydrogen, halogen, cyano, nitro, —C(O)R C1 , C 1 -C 10 alkyl, C 2 -C 10 alkenyl, C 2 -C 10 alkynyl, C 1 -C 10 haloalkyl, C 3 -C 7 cycloalkyl, C 3 -C 7 cycloalkyl(C 1 -C 10 )alkyl, heterocycloalkyl, aryl, or heteroaryl, wherein
each alkyl, aryl, cycloalkyl, heterocycloalkyl, and heteroaryl group is optionally substituted with from 1-4 groups that are independently C 1 -C 6 alkyl, C 1 -C 6 alkoxy, halogen, hydroxy, amino, mono- or di-(C 1 -C 6 ) alkylamino, cyano, nitro, halo(C 1 -C 6 )alkyl, halo(C 1 -C 6 )alkoxy, carboxamide, heterocycloalkyl, aryl, or heteroaryl, wherein the aryl and heteroaryl groups are optionally substituted with from 1-4 groups that are independently C 1 -C 6 alkyl, C 1 -C 6 alkoxy, halogen, hydroxy, amino, mono- or di-(C 1 -C 6 ) alkylamino, halo(C 1 -C 6 )alkyl, or carboxamide;
R C1 is —C 1 -C 6 alkyl, —OR C2 , or —N(R CN ) 2 , wherein
R C2 is —H, C 1 -C 10 alkyl, C 1 -C 10 haloalkyl, C 3 -C 7 cycloalkyl, heterocycloalkyl, aryl, or heteroaryl;
each R CN is independently —H, C 1 -C 10 alkyl, C 1 -C 10 haloalkyl, C 3 -C 7 cycloalkyl, heterocycloalkyl, C 1 -C 6 acyl, aryl, or heteroaryl, wherein each alkyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl group is optionally substituted with from 1-4 groups that are independently C 1 -C 6 alkyl, C 1 -C 6 alkoxy, halogen, hydroxy, amino, mono- or di-(C 1 -C 6 ) alkylamino, nitro, halo(C 1 -C 6 )alkyl, halo(C 1 -C 6 )alkoxy, or carboxamide.
2 . (canceled)
3 . A compound according to claim 1 , wherein R 41 is —C(O)NR 1 R 2 and R 6 is —Z 1 R Z1 , and wherein
Z 1 is —O—, —NH—, —S(O) p —, or —S(O) 2 NH—, wherein p is 0, 1 or 2; and
R Z1 is a C 1 -C 14 alkyl group where up to five of the carbon atoms in the alkyl group are optionally replaced independently by R 22 , carbonyl, ethenyl, ethynyl or a moiety selected from N, O, S, SO 2 , or SO, with the proviso that two O atoms, two S atoms, or an O and S atom are not immediately adjacent each other, and wherein R Z1 is optionally substituted at any available position with C 1 -C 10 alkyl, C 1 -C 10 haloalkyl, C 2 -C 10 alkenyl, C 2 -C 10 alkynyl, hydroxy, carboxy, carboxamido, oxo, halo, amino, cyano, nitro, —SH, —S—(C 1 -C 6 )alkyl, —SO 2 —(C 1 -C 6 )alkyl, —SO 2 NH 2 , —SO 2 NH—(C 1 -C 6 )alkyl, —SO 2 NH-aryl, —SO 2 -aryl, —SO—(C 1 -C 6 )alkyl, —SO 2 -aryl, C 1 -C 6 alkoxy, C 2 -C 10 alkenyloxy, C 2 -C 10 alkynyloxy, mono- or di-(C 1 -C 10 )alkylamino, —OC 1 -C 10 alkyl-Z, or R 23 .
4 . A compound of claim 3 , wherein Z 1 is —O— or —NH—.
5 . (canceled)
6 . A compound according to claim 1 , wherein
Z 1 is —NH—; R 6 is —NR 7 R 8 , wherein R 7 is (C 1 -C 14 )alkyl, (C 2 -C 14 )alkenyl, (C 2 -C 14 )alkynyl, aryl, aryl(C 1 -C 8 )alkyl, (C 3 -C 8 )cycloalkenyl, (C 3 -C 8 )cycloalkenyl(C 1 -C 8 )alkyl, (C 3 -C 8 )cycloalkyl, (C 3 -C 8 )cycloalkyl(C 1 -C 8 )alkyl, heteroaryl, heteroaryl(C 1 -C 8 )alkyl, heteroaryl(C 1 -C 8 )alkylthio(C 1 -C 8 )alkyl, heteroarylthio(C 1 -C 8 )alkyl, heterocyclyl, heterocycle(C 1 -C 8 )alkyl, or hydroxy(C 1 -C 8 )alkyl,
wherein each is optionally substituted with 1, 2, 3, 4, or 5 groups which are independently (C 2 -C 8 )alkenyl, (C 1 -C 8 )alkoxy, (C 1 -C 8 )alkoxy(C 1 -C 8 )alkyl, (C 1 -C 8 )alkoxycarbonyl, (C 1 -C 8 )alkyl, (C 1 -C 8 )alkylcarbonyl, (C 1 -C 8 )alkylcarbonyloxy, (C 1 -C 8 )alkylsulfinyl, (C 1 -C 8 )alkylsulfonyl, (C 1 -C 8 )alkylthio, (C 2 -C 8 )alkynyl, carboxy, carboxy(C 1 -C 8 )alkyl, cyano, cyano(C 1 -C 8 )alkyl, (C 3 -C 8 )cycloalkyl, (C 3 -C 8 )cycloalkyl(C 1 -C 8 )alkyl, formyl, halo(C 1 -C 8 )alkoxy, halo(C 1 -C 8 )alkyl, halogen, hydroxy, hydroxy(C 1 -C 8 )alkoxy, hydroxy(C 1 -C 8 )alkoxy(C 1 -C 8 )alkoxy, hydroxy(C 1 -C 8 )alkyl, mercapto, nitro, —NR 12 R 13 , (NR 12 R 13 )(C 1 -C 8 )alkyl, (NR 12 R 13 )carbonyl, oxo, HOCH 2 CH(NH 2 )C(O)O—, NH 2 (CH 2 ) m C(O)O—, CH 3 NH(CH 2 ) m C(O)O—, (CH 3 ) 2 N(CH 2 ) m C(O)O—, NH 2 (CH 2 ) t C(O)NH(CH 2 ) m C(O)O—, R 13 CH(NH 2 )C(O)O—, NH 2 (CH 2 ) m C(R 13 ) 2 (CH 2 ) m C(O)O—, NH 2 CH 2 CH 2 C(O)O—, R 12 ON═CH(CH 2 ) n O—, HONHC(O)(CH 2 ) n O—, —OP(O)(OR P ) 2 , —OS(O) 2 OR S , or R 20 ;
where each m is independently 1, 2, 3, or 4;
where each n is 1, 2, 3, 4, 5, or 6;
where t is 1, 2, 3, or 4;
where R 12 and R 13 are independently —H, (C 2 -C 8 )alkenyl, (C 1 -C 8 )alkyl, (C 1 -C 8 )alkylcarbonyl, (C 2 -C 8 )alkynyl, aryl, aryl(C 1 -C 8 )alkyl, (C 3 -C 8 )cycloalkyl, (C 3 -C 8 )cycloalkyl(C 1 -C 8 )alkyl, formyl, heteroaryl, heteroaryl(C 1 -C 8 )alkyl, heterocyclyl, or heterocycle(C 1 -C 8 )alkyl; or two R 12 groups together with the carbon to which they are attached form a (C 3 -C 8 )cycloalkyl group;
where each R P and R S is independently hydrogen, (C 1 -C 6 )alkyl, (C 1 -C 6 )haloalkyl, or aryl, wherein the alkyl or aryl is optionally substituted with one or more groups independently selected from (C 1 -C 6 )alkyl, (C 1 -C 6 )alkoxy, halogen, hydroxy, amino, mono- or di-(C 1 -C 6 )alkylamino, nitro, halo(C 1 -C 6 )alkyl, carboxy, or carboxamide;
where R 20 is:
wherein
d and k are integers independently selected from 1 and 2;
R 201 is (C 1 -C 6 )alkyl where the alkyl is optionally substituted with (C 3 -C 7 )cycloalkyl, (C 2 -C 6 ) alkenyl, (C 2 -C 6 )alkynyl, hydroxy, halogen, nitro, or cyano; and
T is O or NR 202 where R 202 is hydrogen or (C 1 -C 6 )alkyl; and
R 301 and R 302 are independently hydrogen or (C 1 -C 6 )alkyl, and
R 303 is absent, hydrogen, or (C 1 -C 6 )alkyl; and
R 8 is hydrogen or (C 1 -C 8 )alkyl.
7 . A compound according to claim 6 , wherein R 1 and R 2 are independently hydrogen or methyl.
8 . (canceled)
9 . A compound according to claim 1 , wherein R 41 is cyano.
10 - 35 . (canceled)
36 . A compound according to claim 1 , wherein bond “ ” is a single bond.
37 - 70 . (canceled)
71 . A compound according to claim 1 , which is:
2-fluoro-6-((1S,2S)-2-hydroxycyclopentylamino)-4-(3,6,6-trimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)benzamide; 2-fluoro-6-((1S,2S)-2-hydroxycyclopentylamino)-4-(3,6,6-trimethyl-6,7-dihydro-1H-indazol-1-yl)benzamide; 2-fluoro-6-(4-hydroxycyclohexylamino)-4-(3,6,6-trimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)benzamide; 2-(cyclohexylamino)-6-fluoro-4-(3,6,6-trimethyl-6,7-dihydro-1H-indazol-1-yl)benzamide; 2-(cyclohexylamino)-6-fluoro-4-(3,6,6-trimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)benzamide; 2-fluoro-6-(tetrahydrofuran-3-ylamino)-4-(3,6,6-trimethyl-6,7-dihydro-1H-indazol-1-yl)benzamide; 2-fluoro-6-(tetrahydrofuran-3-ylamino)-4-(3,6,6-trimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)benzamide; 2-fluoro-6-(2-hydroxycyclohexylamino)-4-(3,6,6-trimethyl-6,7-dihydro-1H-indazol-1-yl)benzamide; 2-fluoro-6-(2-hydroxycyclohexylamino)-4-(3,6,6-trimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)benzamide; 2-fluoro-6-((1r,4r)-4-hydroxycyclohexylamino)-4-(3,4,6,6-tetramethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)benzamide; 2-fluoro-6-((1r,4r)-4-hydroxycyclohexylamino)-4-(3,4,6,6-tetramethyl-6,7-dihydro-1H-indazol-1-yl)benzamide; or a pharmaceutically acceptable salt thereof.
72 . A compound according to claim 1 which is
2-(trans-4-(cyclopropylmethylamino)cyclohexylamino)-4-(6,6-dimethyl-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)benzamide;
2,6-difluoro-4-(4-hydroxy-6,6-dimethyl-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)benzonitrile;
4-(6,6-dimethyl-3-(trifluoromethyl)-6,7-dihydro-1H-indazol-1-yl)-2,6-difluorobenzonitrile;
4-(3-ethyl-4-hydroxy-6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2,6-difluorobenzonitrile;
4-(3-ethyl-6,6-dimethyl-6,7-dihydro-1H-indazol-1-yl)-2,6-difluorobenzonitrile;
2-fluoro-6-(trans-4-methoxycyclohexylamino)-4-(3,6,6-trimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)benzamide;
2-(trans-4-hydroxycyclohexylamino)-4-(3-(hydroxymethyl)-6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)benzamide;
4-(3-Ethyl-6,6-dimethyl-4,5,6,7-tetrahydro-indazol-1-yl)-2,3-difluorobenzonitrile;
4-(3-ethyl-6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)-3-fluoro-2-((1S,2S)-2-hydroxycyclohexylamino)benzamide;
4-(3-Ethyl-6,6-dimethyl-4,5,6,7-tetrahydro-indazol-1-yl)-2,3,5,6-tetrafluoro-benzonitrile;
4-(3-ethyl-6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2,3,5-trifluoro-6-(trans-4-hydroxycyclohexylamino)benzamide;
2-fluoro-6-(2-oxoazepan-3-ylamino)-4-(3,6,6-trimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)benzamide;
2-(1-(2-hydroxyethyl)-1H-pyrazol-4-ylamino)-4-(3,6,6-trimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)benzamide;
2-(1-(2-(isobutylamino)ethyl)-1H-pyrazol-4-ylamino)-4-(3,6,6-trimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)benzamide;
2-(1,3-dihydroxypropan-2-ylamino)-6-fluoro-4-(3,6,6-trimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)benzamide;
4-(3-Cyclopropylmethyl-6,6-dimethyl-4,5,6,7-tetrahydroindazol-1-yl)-2,5-difluorobenzonitrile;
(R)-4-(3-(cyclopropylmethyl)-6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)-5-fluoro-2-(tetrahydrofuran-3-ylamino)benzamide;
4-(6,6-dimethyl-3-(pyridin-2-ylmethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-(tetrahydro-2H-pyran-4-ylamino)benzamide;
4-(3-Ethyl-6,6-dimethyl-4,5,6,7-tetrahydroindazol-1-yl)-2-fluorobenzonitrile;
(S)-4-(3-ethyl-6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-(tetrahydrofuran-3-ylamino)benzamide;
(S)-4-(6,6-dimethyl-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-(piperidin-3-ylamino)benzamide;
(S)-4-(6,6-dimethyl-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-(1-neopentylpiperidin-3-ylamino)benzamide;
2-((1S,2S)-2-aminocyclohexylamino)-6-fluoro-4-(3,6,6-trimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)benzamide;
2-fluoro-6-((1S,2S)-2-(neopentylamino)cyclohexylamino)-4-(3,6,6-trimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)benzamide;
2-(2-((1H-imidazol-2-yl)methylthio)ethylamino)-4-(3-ethyl-6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)-6-fluorobenzamide;
2-(cyclopent-3-enylamino)-6-fluoro-4-(3,6,6-trimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)benzamide;
(S)-4-(6,6-dimethyl-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-(1-(prop-2-ynyl)pyrrolidin-3-ylamino)benzamide;
2-(cyclobutylamino)-4-(3-ethyl-6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)-6-fluorobenzamide;
(R)-4-(6,6-dimethyl-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-(2-hydroxypropylamino)benzamide;
2-(trans-4-aminocyclohexylamino)-4-(6,6-dimethyl-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)benzamide;
4-(3-ethyl-6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-fluoro-6-(tetrahydro-2H-pyran-4-ylamino)benzamide;
2-fluoro-6-(tetrahydro-2H-pyran-4-ylamino)-4-(3,6,6-trimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)benzamide;
2-fluoro-6-(((S)-tetrahydrofuran-3-yl)amino)-4-(4,6,6-trimethyl-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)benzamide;
(S)-4-(6,6-dimethyl-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-fluoro-6-((tetrahydrofuran-3-yl)amino)benzamide;
2-fluoro-6-(((1S,2S)-2-hydroxycyclopentyl)amino)-4-(3,4,6,6-tetramethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)benzamide;
4-(3-ethyl-6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-fluoro-6-((1S,2S)-2-hydroxycyclopentylamino)benzamide;
4-(6,6-dimethyl-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-fluoro-6-(((1r,4r)-4-hydroxycyclohexyl)amino)benzamide;
2-fluoro-6-(((1r,4r)-4-hydroxycyclohexyl)amino)-4-(4,6,6-trimethyl-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)benzamide;
4-(6,6-dimethyl-3-(trifluoromethyl)-6,7-dihydro-1H-indazol-1-yl)-2-fluoro-6-(((1r,4r)-4-hydroxycyclohexyl)amino)benzamide;
2-fluoro-6-(((1r,4r)-4-hydroxycyclohexyl)amino)-4-(4,6,6-trimethyl-3-(trifluoromethyl)-6,7-dihydro-1H-indazol-1-yl)benzamide;
4-(3-ethyl-6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-fluoro-6-(trans-4-hydroxycyclohexylamino)benzamide;
4-(6,6-dimethyl-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-((1S,2S)-2-hydroxycyclohexylamino)benzamide;
4-(6,6-dimethyl-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-((1S,2S)-2-hydroxycyclopentylamino)benzamide;
4-(3-ethyl-6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-((1S,2S)-2-hydroxycyclohexylamino)benzamide;
4-(3-ethyl-6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-((1S,2S)-2-hydroxycyclopentylamino)benzamide;
(S)-2-(tetrahydrofuran-3-ylamino)-4-(3,6,6-trimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)benzamide 2-((1S,2S)-2-hydroxycyclopentylamino)-4-(3,6,6-trimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)benzamide;
2-((1S,2S)-2-hydroxycyclohexylamino)-4-(3,6,6-trimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)benzamide;
2-(cyclopentylamino)-4-(3-ethyl-6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)-6-fluorobenzamide;
(1S,2S)-2-(2-carbamoyl-5-(3-ethyl-6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)-3-fluorophenylamino)cyclopentyl 2-aminoacetate hydrochloride;
(1S,2S)-2-(2-carbamoyl-3-fluoro-5-(3,6,6-trimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)phenylamino)cyclopentyl 2-aminoacetate maleate;
(trans)-4-(2-carbamoyl-5-(3-ethyl-6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)-3-fluorophenylamino)cyclohexyl 2-aminoacetate hydrochloride;
trans-4-(2-carbamoyl-3-fluoro-5-(3,6,6-trimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)phenylamino)cyclohexyl 2-aminoacetate methanesulfonate;
2-(cyclopentylamino)-6-fluoro-4-(3,6,6-trimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)benzamide;
4-(6,6-dimethyl-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-fluoro-6-((1S,2S)-2-hydroxycyclopentylamino)benzamide;
(1S,2S)-2-(2-carbamoyl-5-(6,6-dimethyl-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)-3-fluorophenylamino)cyclopentyl 2-aminoacetate;
4-(6,6-dimethyl-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-fluoro-6-(tetrahydro-2H-pyran-4-ylamino)benzamide;
4-(6,6-dimethyl-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-fluoro-6-((1S,2S)-2-hydroxycyclohexylamino)benzamide;
(1S,2S)-2-(2-carbamoyl-5-(6,6-dimethyl-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)-3-fluorophenylamino)cyclohexyl 2-aminoacetate methanesulfonate;
(1S,2S)-2-(2-carbamoyl-5-(3-ethyl-6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)phenylamino)cyclohexyl 2-aminoacetate;
(1S,2S)-2-(2-carbamoyl-5-(6,6-dimethyl-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)phenylamino)cyclopentyl 2-aminoacetate methanesulfonate;
(1S,2S)-2-(2-carbamoyl-5-(6,6-dimethyl-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)phenylamino)cyclohexyl 2-aminoacetate methanesulfonate 4-(3-ethyl-6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-((1S,2S)-2-hydroxycyclopentylamino)-6-methoxybenzamide;
5-(6,6-dimethyl-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)-3-((trans)-4-hydroxycyclohexylamino)picolinamide;
4-(3-ethyl-6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-fluoro-6-((1S,2S)-2-hydroxycyclopentylamino)benzamide;
2-(4,4-Difluoro-cyclohexylamino)-6-fluoro-4-(3,6,6-trimethyl-4,5,6,7-tetrahydro-indazol-1-yl)-benzamide;
2-(cyclohexylamino)-4-(6,6-dimethyl-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)-6-fluorobenzamide;
trans-4-(2-carbamoyl-3-fluoro-5-(3,6,6-trimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)phenylamino)cyclohexyl 2-(tert-butoxycarbonylamino)acetate;
(1S,2S)-2-(2-carbamoyl-5-(6,6-dimethyl-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)phenylamino)cyclopentyl 2-(tert-butoxycarbonylamino)acetate;
4-(3-(cyclopropylmethyl)-6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-fluoro-6-(tetrahydro-2H-pyran-4-ylamino)benzamide;
2-fluoro-6-(tetrahydro-2H-pyran-4-ylamino)-4-(3,6,6-trimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)benzamide;
4-(3-ethyl-6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)-3-fluoro-2-(trans-4-hydroxycyclohexylamino)benzamide;
(S)-2-fluoro-6-(tetrahydrofuran-3-ylamino)-4-(3,6,6-trimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)benzamide;
(R)-2-fluoro-6-(tetrahydrofuran-3-ylamino)-4-(3,6,6-trimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)benzamide;
2-((1S,2S)-2-aminocyclohexylamino)-4-(3-ethyl-6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)-6-fluorobenzamide;
4-(3-(cyclopropylmethyl)-6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-fluoro-6-((1S,2S)-2-hydroxycyclopentylamino)benzamide;
4-(3-(cyclopropylmethyl)-6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-fluoro-6-((1S,2S)-2-hydroxycyclohexylamino)benzamide;
4-(3-(cyclopropylmethyl)-6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-fluoro-6-(trans-4-hydroxycyclohexylamino)benzamide;
4-(3-(cyclopropylmethyl)-6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)-5-fluoro-2-(trans-4-hydroxycyclohexylamino)benzamide;
4-(3-ethyl-6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)-5-fluoro-2-(trans-4-hydroxycyclohexylamino)benzamide;
2-fluoro-6-((1S,2S)-2-hydroxycyclopentylamino)-4-(3,6,6-trimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)benzamide;
2-(cyclopropylmethylamino)-4-(3-ethyl-6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)-6-fluorobenzamide;
4-(6,6-dimethyl-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-fluoro-6-(((1S,2S)-2-hydroxycyclohexyl)amino)benzamide;
4-(6,6-dimethyl-3-(trifluoromethyl)-6,7-dihydro-1H-indazol-1-yl)-2-fluoro-6-(((1S,2S)-2-hydroxycyclohexyl)amino)benzamide;
(S)-4-(3-ethyl-6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-fluoro-6-(tetrahydrofuran-3-ylamino)benzamide;
4-(3-ethyl-6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-fluoro-6-((1S,2S)-2-hydroxycyclohexylamino)benzamide;
(R)-4-(3-ethyl-6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-fluoro-6-(tetrahydrofuran-3-ylamino)benzamide;
(S)-4-(3-(cyclopropylmethyl)-6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-fluoro-6-(tetrahydrofuran-3-ylamino)benzamide;
(R)-4-(3-(cyclopropylmethyl)-6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-fluoro-6-(tetrahydrofuran-3-ylamino)benzamide;
4-(3-ethyl-6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)-3-fluoro-2-(tetrahydro-2H-pyran-4-ylamino)benzamide;
4-(3-(cyclopropylmethyl)-6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)-3-fluoro-2-(tetrahydro-2H-pyran-4-ylamino)benzamide;
4-(3-ethyl-6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)-3-fluoro-2-(2-hydroxyethylamino)benzamide;
4-(3-(cyclopropylmethyl)-6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)-3-fluoro-2-(trans-4-hydroxycyclohexylamino)benzamide;
4-(3-(cyclopropylmethyl)-6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)-3-fluoro-2-((1S,2S)-2-hydroxycyclohexylamino)benzamide;
4-(3-ethyl-6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-fluoro-6-((1S,2S)-2-hydroxycyclopentylamino)benzamide;
4-(3-(cyclopropylmethyl)-6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)-5-fluoro-2-(tetrahydro-2H-pyran-4-ylamino)benzamide;
4-(3-ethyl-6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)-5-fluoro-2-(tetrahydro-2H-pyran-4-ylamino)benzamide;
(R)-4-(3-ethyl-6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)-5-fluoro-2-(tetrahydrofuran-3-ylamino)benzamide;
4-(3-(cyclopropylmethyl)-6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)-5-fluoro-2-((1S,2S)-2-hydroxycyclohexylamino)benzamide;
4-(3-(cyclopropylmethyl)-6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)-5-fluoro-2-((1S,2S)-2-hydroxycyclopentylamino)benzamide;
4-(3-ethyl-6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)-5-fluoro-2-((1S,2S)-2-hydroxycyclopentylamino)benzamide;
4-(3-ethyl-6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)-3,5-difluoro-2-(tetrahydro-2H-pyran-4-ylamino)benzamide;
4-(3-ethyl-6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)-3,5-difluoro-2-((R)-tetrahydrofuran-3-ylamino)benzamide;
4-(3-(cyclopropylmethyl)-6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)-3,5-difluoro-2-((R)-tetrahydrofuran-3-ylamino)benzamide;
4-(3-(cyclopropylmethyl)-6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)-3,5-difluoro-2-(tetrahydro-2H-pyran-4-ylamino)benzamide;
4-(3-ethyl-6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-fluoro-6-((1S,2S)-2-(neopentylamino)cyclohexylamino)benzamide;
4-(3-ethyl-6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-fluoro-6-(trans-4-(neopentylamino)cyclohexylamino)benzamide;
4-(3-ethyl-6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-fluoro-6-(2-oxotetrahydrofuran-3-ylamino)benzamide;
4-(3-(cyclopropylmethyl)-6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)-3,5-difluoro-2-(trans-4-hydroxycyclohexylamino)benzamide;
methyl 2-(2-carbamoyl-5-(3-ethyl-6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)-3-fluorophenylamino)-4-hydroxybutanoate;
2-(cyclopent-3-enylamino)-4-(3-ethyl-6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)-6-fluorobenzamide;
2-(1-acetylpiperidin-4-ylamino)-4-(3-ethyl-6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)-6-fluorobenzamide6H;
4-(3-(cyclopropylmethyl)-6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-fluoro-6-(2-oxotetrahydrofuran-3-ylamino)benzamide;
2-fluoro-6-(4-hydroxycyclohexylamino)-4-(3,6,6-trimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)benzamide;
2-fluoro-6-(2-oxotetrahydrofuran-3-ylamino)-4-(3,6,6-trimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)benzamide;
4-(3-ethyl-6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-fluoro-6-(2-oxoazepan-3-ylamino)benzamide;
2-(2,2-dimethoxyethylamino)-4-(3-ethyl-6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)-6-fluorobenzamide;
4-(3-ethyl-6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-fluoro-6-(trans-4-hydroxycyclohexylamino)benzamide;
4-(3-ethyl-6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-fluoro-6-(trans-4-methoxycyclohexylamino)benzamide;
4-(3-ethyl-6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-fluoro-6-((1S,2R)-2-hydroxycyclohexylamino)benzamide;
4-(3-ethyl-6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-fluoro-6-((1S,2R)-2-hydroxycyclopentylamino)benzamide;
2-(cyclopentylamino)-4-(3-ethyl-6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)-6-fluorobenzamide;
(1S,2S)-2-(2-carbamoyl-5-(3-ethyl-6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)-3-fluorophenylamino)cyclohexyl 2-aminoacetate;
(1S,2S)-2-(2-carbamoyl-5-(3-ethyl-6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)-3-fluorophenylamino)cyclopentyl 2-aminoacetate;
(1S,2S)-2-(2-carbamoyl-3-fluoro-5-(3,6,6-trimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)phenylamino)cyclopentyl 2-aminoacetate;
(1S,2S)-2-(2-carbamoyl-3-fluoro-5-(3,6,6-trimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)phenylamino)cyclohexyl 2-aminoacetate;
(trans)-4-(2-carbamoyl-5-(3-ethyl-6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)-3-fluorophenylamino)cyclohexyl 2-aminoacetate;
(trans)-4-(2-carbamoyl-3-fluoro-5-(3,6,6-trimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)phenylamino)cyclohexyl 2-aminoacetate;
(S)-2-fluoro-6-(6-oxotetrahydro-2H-pyran-3-ylamino)-4-(3,6,6-trimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)benzamide;
(R)-2-fluoro-6-(6-oxotetrahydro-2H-pyran-3-ylamino)-4-(3,6,6-trim ethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)benzamide;
2-fluoro-6-((cis)-4-hydroxycyclohexylamino)-4-(3,6,6-trimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)benzamide;
2-fluoro-6-(oxetan-3-ylamino)-4-(3,6,6-trimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)benzamide;
2-(cyclopentylamino)-6-fluoro-4-(3,6,6-trimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)benzamide;
2-(cycloheptylamino)-6-fluoro-4-(3,6,6-trimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)benzamide;
(trans)-4-(2-carbamoyl-5-(6,6-dimethyl-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)-3-fluorophenylamino)cyclohexyl 2-aminoacetate;
4-(6,6-dimethyl-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-fluoro-6-((1S,2S)-2-hydroxycyclopentylamino)benzamide;
(1S,2S)-2-(2-carbamoyl-5-(6,6-dimethyl-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)-3-fluorophenylamino)cyclopentyl 2-aminoacetate;
4-(6,6-dimethyl-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-fluoro-6-(tetrahydro-2H-pyran-4-ylamino)benzamide;
4-(6,6-dimethyl-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-fluoro-6-((1S,2S)-2-hydroxycyclohexylamino)benzamide;
(1S,2S)-2-(2-carbamoyl-5-(6,6-dimethyl-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)-3-fluorophenylamino)cyclohexyl 2-aminoacetate;
(S)-4-(6,6-dimethyl-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-fluoro-6-(tetrahydrofuran-3-ylamino)benzamide;
2-fluoro-6-((1S,2R)-2-hydroxycyclopentylamino)-4-(3,6,6-trimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)benzamide;
2-(4,4-difluorocyclohexylamino)-6-fluoro-4-(3,6,6-trimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)benzamide;
2-(cyclopentylamino)-4-(6,6-dimethyl-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)-6-fluorobenzamide;
2-(cyclohexylamino)-6-fluoro-4-(3,6,6-trimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)benzamide;
2-fluoro-6-((1R,2R)-2-hydroxycyclopentylamino)-4-(3,6,6-trimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)benzamide;
(1R,2R)-2-(2-carbamoyl-3-fluoro-5-(3,6,6-trimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)phenylamino)cyclopentyl 2-aminoacetate;
(S)-(trans-4-(2-carbamoyl-5-(6,6-dimethyl-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)phenylamino)cyclohexyl) 2-amino-3-hydroxypropanoate;
trans-4-(2-carbamoyl-5-(6,6-dimethyl-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)phenylamino)cyclohexyl 2-(dimethylamino)acetate;
4-(6,6-dimethyl-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-(pyrimidin-2-ylamino)benzamide;
4-(6,6-dimethyl-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-(pyrimidin-4-ylamino)benzamide;
4-(6,6-dimethyl-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-(pyrimidin-5-ylamino)benzamide;
4-(3-(difluoromethyl)-6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-(1-(prop-2-ynyl)piperidin-4-ylamino)benzamide;
2-(1-cyclopropylpiperidin-4-ylamino)-4-(3-(difluoromethyl)-6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)benzamide;
4-(3-(difluoromethyl)-6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-(1-(2-methoxyethyl)piperidin-4-ylamino)benzamide;
4-(6,6-dimethyl-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-(2-(2-hydroxyethoxy)pyridin-4-ylamino)benzamide;
2-(1-(2-(methylamino)ethyl)-1H-pyrazol-4-ylamino)-4-(3,6,6-trimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)benzamide;
4-(6,6-dimethyl-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-(trans-4-(prop-2-ynylamino)cyclohexylamino)benzamide;
4-(6,6-dimethyl-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-(1-(prop-2-ynyl)piperidin-4-ylamino)benzamide;
2-(azetidin-3-ylamino)-4-(6,6-dimethyl-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)benzamide;
2-((1S,2S)-2-aminocyclohexylamino)-4-(6,6-dimethyl-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)benzamide;
4-(6,6-dimethyl-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-(2-(diprop-2-ynylamino)ethylamino)benzamide;
4-(6,6-dimethyl-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-(2-(prop-2-ynylamino)ethylamino)benzamide;
4-(6,6-dimethyl-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-((1S,2S)-2-(prop-2-ynylamino)cyclohexylamino)benzamide;
2-(1-allylpiperidin-4-ylamino)-4-(6,6-dimethyl-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)benzamide;
2-((1R,2R)-2-aminocyclohexylamino)-4-(6,6-dimethyl-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)benzamide;
2-((1R,2S)-2-aminocyclohexylamino)-4-(6,6-dimethyl-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)benzamide;
(S)-4-(6,6-dimethyl-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-(1-(prop-2-ynyl)piperidin-3-ylamino)benzamide;
(S)-2-(1-allylpiperidin-3-ylamino)-4-(6,6-dimethyl-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)benzamide;
(R)-4-(6,6-dimethyl-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-(piperidin-3-ylamino)benzamide;
4-(6,6-dimethyl-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-(2-(pyrimidin-2-ylthio)ethylamino)benzamide;
(R)-4-(6,6-dimethyl-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-(1-(prop-2-ynyl)piperidin-3-ylamino)benzamide;
(S)-2-(1-(cyclopropylmethyl)piperidin-3-ylamino)-4-(6,6-dimethyl-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)benzamide;
2-(1-(cyclopropylmethyl)piperidin-4-ylamino)-4-(6,6-dimethyl-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)benzamide;
2-(3-aminocyclohexylamino)-4-(6,6-dimethyl-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)benzamide;
2-(1-(2-(tert-butylamino)ethyl)-1H-pyrazol-4-ylamino)-4-(3,6,6-trimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)benzamide;
4-(6,6-dimethyl-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-(pyridazin-4-ylamino)benzamide;
(R)-2-(1-(cyclopropylmethyl)piperidin-3-ylamino)-4-(6,6-dimethyl-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)benzamide;
2-((1S,2S)-2-(cyclopropylmethylamino)cyclohexylamino)-4-(6,6-dimethyl-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)benzamide;
2-(2-(1H-imidazol-2-ylthio)ethylamino)-4-(6,6-dimethyl-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)benzamide;
4-(6,6-dimethyl-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-((1R,2R)-2-(prop-2-ynylamino)cyclohexylamino)benzamide;
4-(6,6-dimethyl-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-((1R,2R)-2-(diprop-2-ynylamino)cyclohexylamino)benzamide;
2-((1R,2R)-2-(cyclopropylmethylamino)cyclohexylamino)-4-(6,6-dimethyl-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)benzamide;
2-((1R,2R)-2-(bis(cyclopropylmethyl)amino)cyclohexylamino)-4-(6,6-dimethyl-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)benzamide;
2-((1S,2S)-2-(diethylamino)cyclohexylamino)-4-(6,6-dimethyl-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)benzamide;
2-((1S,2S)-2-(cyclopropylamino)cyclohexylamino)-4-(6,6-dimethyl-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)benzamide;
4-(6,6-dimethyl-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-(trans-4-(neopentylamino)cyclohexylamino)benzamide;
4-(6,6-dimethyl-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-((1S,2S)-2-(neopentylamino)cyclohexylamino)benzamide;
(1S,2S)-2-(2-carbamoyl-5-(3-ethyl-6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)phenylamino)cyclohexyl 2-aminoacetate;
4-(3-(difluoromethyl)-6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-(2,2,6,6-tetramethylpiperidin-4-ylamino)benzamide;
(1S,2S)-2-(2-carbamoyl-5-(6,6-dimethyl-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)phenylamino)cyclopentyl 2-aminoacetate;
(1S,2S)-2-(2-carbamoyl-5-(6,6-dimethyl-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)phenylamino)cyclohexyl 2-aminoacetate;
(1S,2S)-2-(2-carbamoyl-5-(6,6-dimethyl-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)phenylamino)cyclopentyl 1-aminocyclopropanecarboxylate methanesulfonate;
trans-4-(2-carbamoyl-5-(6,6-dimethyl-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)phenylamino)cyclohexyl 2-(2-aminoacetamido)acetate 2,2,2-trifluoroacetate;
4-(6,6-dimethyl-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-(4-(2-(methoxyimino)ethoxy)cyclohexylamino)benzamide;
4-(6,6-dimethyl-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-(4-(2-(phenoxyimino)ethoxy)cyclohexylamino)benzamide;
2-(trans-4-(2-hydroxyethoxy)cyclohexylamino)-4-(3,6,6-trimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)benzamide;
(R)-2-(tetrahydrofuran-3-ylamino)-4-(3,6,6-trimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)benzamide;
4-(6,6-dimethyl-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-(4-(2-(hydroxyamino)-2-oxoethoxy)cyclohexylamino)benzamide;
2-(trans-4-(2-(2-hydroxyethoxy)ethoxy)cyclohexylamino)-4-(3,6,6-trimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)benzamide;
2-(cyclobutylamino)-4-(6,6-dimethyl-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)benzamide;
2-(4-(2-hydroxyethoxy)cyclohexylamino)-4-(3,6,6-trimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)benzamide;
4-(6,6-dimethyl-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-(2-hydroxyethylamino)benzamide;
2-(cyclobutylamino)-4-(3-ethyl-6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)benzamide;
2-(trans-4-hydroxycyclohexylamino)-4-(3-(3-methoxyphenyl)-6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)benzamide;
4-(3-benzyl-6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-(trans-4-hydroxycyclohexylamino)benzamide;
4-(6,6-dimethyl-3-(1H-pyrazol-4-yl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-(trans-4-hydroxycyclohexylamino)benzamide;
4-(6,6-dimethyl-3-(pyridin-3-ylmethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-(trans-4-hydroxycyclohexylamino)benzamide;
4-(6,6-dimethyl-3-(pyridin-2-ylmethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-(trans-4-hydroxycyclohexylamino)benzamide;
4-(3-(cyclopropylmethyl)-6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-(tetrahydro-2H-pyran-4-ylamino)benzamide;
4-(6,6-dimethyl-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-(2-hydroxycyclohexylamino)benzamide;
4-(6,6-dimethyl-3-(pyridin-2-ylmethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-(2-hydroxyethylamino)benzamide;
4-(3-benzyl-6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-(2-hydroxyethylamino)benzamide;
4-(3-(cyclopropylmethyl)-6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-(2-hydroxyethylamino)benzamide;
4-(3-benzyl-6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-(tetrahydro-2H-pyran-4-ylamino)benzamide;
(R)-4-(6,6-dimethyl-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-(1-hydroxypropan-2-ylamino)benzamide;
(S)-4-(6,6-dimethyl-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-(1-hydroxypropan-2-ylamino)benzamide;
(S)-4-(6,6-dimethyl-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-(2-hydroxypropylamino)benzamide;
4-(6,6-dimethyl-3-(pyridin-3-ylmethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-(tetrahydro-2H-pyran-4-ylamino)benzamide;
4-(6,6-dimethyl-3-(pyridin-4-ylmethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-(2-hydroxyethylamino)benzamide;
4-(6,6-dimethyl-3-(pyridin-3-ylmethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-(2-hydroxyethylamino)benzamide;
4-(6,6-dimethyl-3-(thiophen-3-ylmethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-(2-hydroxyethylamino)benzamide;
4-(6,6-dimethyl-3-(pyridin-4-ylmethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-(tetrahydro-2H-pyran-4-ylamino)benzamide;
4-(6,6-dimethyl-3-(pyridin-4-ylmethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-(trans-4-hydroxycyclohexylamino)benzamide;
4-(6,6-dimethyl-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-((1S,2S)-2-hydroxycyclohexylamino)benzamide;
(R)-4-(3-(cyclopropylmethyl)-6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-(tetrahydrofuran-3-ylamino)benzamide;
4-(6,6-dimethyl-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-((1R,2R)-2-hydroxycyclohexylamino)benzamide;
4-(6,6-dimethyl-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-((1R,2R)-2-hydroxycyclopentylamino)benzamide;
4-(6,6-dimethyl-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-((1S,2S)-2-hydroxycyclopentylamino)benzamide;
4-(3-ethyl-6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-((1S,2S)-2-hydroxycyclohexylamino)benzamide;
4-(3-(cyclopropylmethyl)-6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-((1S,2S)-2-hydroxycyclopentylamino)benzamide;
4-(3-(cyclopropylmethyl)-6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-((1S,2S)-2-hydroxycyclohexylamino)benzamide;
4-(3-ethyl-6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-((1S,2S)-2-hydroxycyclopentylamino)benzamide;
(S)-2-(tetrahydrofuran-3-ylamino)-4-(3,6,6-trimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)benzamide;
2-((1S,2S)-2-hydroxycyclopentylamino)-4-(3,6,6-trimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)benzamide;
2-((1S,2S)-2-hydroxycyclohexylamino)-4-(3,6,6-trimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)benzamide;
2-(oxetan-3-ylamino)-4-(3,6,6-trimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)benzamide;
(S)-4-(6,6-dimethyl-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-(tetrahydrofuran-3-ylamino)benzamide;
4-(6-ethyl-3,6-dimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-((trans)-4-hydroxycyclohexylamino)benzamide;
2-(cyclopentylamino)-4-(3,6,6-trimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)benzamide;
2-(cycloheptylamino)-4-(3,6,6-trimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)benzamide;
4-(3-ethyl-6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-methoxy-6-(tetrahydro-2H-pyran-4-ylamino)benzamide;
4-(6,6-dimethyl-3-(2,2,2-trifluoroethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-(trans-4-hydroxycyclohexylamino)benzamide;
4-(6,6-dimethyl-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-((1S,2R)-2-hydroxycyclopentylamino)benzamide;
2-(cyclopentylamino)-4-(6,6-dimethyl-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)benzamide;
2-(cyclohexylamino)-4-(3,6,6-trimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)benzamide;
4-(3,6,6-trimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)-1H-benzo[d]imidazole-7-carboxamide;
4-(3-ethyl-6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)-1H-benzo[d]imidazole-7-carboxamide;
4-(3-ethyl-6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-methyl-1H-benzo[d]imidazole-7-carboxamide;
2-phenyl-4-(3,6,6-trimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)-1H-benzo[d]imidazole-7-carboxamide;
4-(3-ethyl-6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-phenyl-1H-benzo[d]imidazole-7-carboxamide; or
a pharmaceutically acceptable salt thereof.
73 . A pharmaceutical composition comprising at least one compound or salt according to claim 1 and a pharmaceutically acceptable solvent, carrier, excipient, adjuvant or a combination thereof.
74 . A method of treating cancer, inflammation, infection, or arthritis comprising administering to a patient in need of such treatment a therapeutically effective amount of a compound or salt according to claim 1 .
75 . A package comprising a compound according to claim 1 in a container with instructions on how to use the compound.
76 . A method of treating a disease or condition related to cell proliferation comprising administering a therapeutically effective amount of a compound of claim 1 to a patient in need of such treatment.
77 . A method according to claim 76 , wherein the disease or condition is cancer, inflammation, infection, or arthritis.
78 . A method according to claim 77 , the disease is cancer.
79 . A method according to claim 77 , the disease is infection, and the infection is a viral infection selected from Human Immunodeficiency Virus Type 1 (HIV), hepatitis C (HCV), hepatitis B (HBV), and ebola (EBOV) infection.
80 . A method for treating a subject suffering from a disease or disorder of proteins that are either client proteins for HSP-90 or indirectly affect its client proteins, comprising administering to a subject in need of such treatment a therapeutically effective amount of a compound or salt according to claim 1 .
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