Wearable automatic injection system and apparatus

Abstract

A wearable automatic injection device is provided for administering a final medicament to a patient. The wearable automatic injection device comprises a housing, an injection assembly for injecting the patient with the final medicament, a container holding a bulk intermediate medicament and a diluent to be mixed to form the medicament, and a mixing mechanism for mixing the bulk intermediate medicament and the diluent in the container to form the final medicament prior. A system for administering a final medicament to a patient is also provided. The system comprises a container, a mixing mechanism for mixing a bulk intermediate medicament and a diluent in the container to form the final medicament, and a wearable automatic injection device configured to receive the container.

What is claimed is: 
     
         1 . A wearable automatic injection device for administering a final medicament to a patient, the wearable automatic injection device comprising:
 a housing including:
 an intermediate container holding a bulk intermediate medicament; and 
 a mixing chamber including one or more electromechanical mixing mechanisms to mix the bulk intermediate medicament and a diluent to form the final medicament. 
   
     
     
         2 . The wearable automatic injection device of  claim 1 , wherein the housing further comprises an activation mechanism for initiating an injection assembly after the final medicament is formed for administering the final medicament to the patient. 
     
     
         3 . The wearable automatic injection device of  claim 2 , wherein the activation mechanism initiates the one or more electromechanical mixing mechanisms based on a user actuating a button on the wearable automatic injection device. 
     
     
         4 . The wearable automatic injection device of  claim 1 , wherein the housing further comprises an injection assembly including a needle and a fluid pathway for injecting the patient with the final medicament. 
     
     
         5 . The wearable automatic injection device of  claim 1 , wherein the intermediate container further comprises the diluent. 
     
     
         6 . The wearable automatic injection device of  claim 1 , wherein the housing further comprises a second container holding the diluent, and the mixing chamber is in fluid communication with the intermediate container and the second container. 
     
     
         7 . The wearable automatic injection device of  claim 1 , further comprising a turbidity meter to automatically verify mixing of the bulk intermediate medicament and the diluent. 
     
     
         8 . The wearable automatic injection device of  claim 1 , further comprising an inspection window disposed in the housing for a user to visually inspect the final medicament. 
     
     
         9 . The wearable automatic injection device of  claim 1 , wherein the intermediate container stores the bulk intermediate medicament and diluent separately. 
     
     
         10 . The wearable automatic injection device of  claim 1 , wherein the bulk intermediate medicament is in dry form, the bulk intermediate medicament is dried by lyophilization, spray freeze dried, or spray dried. 
     
     
         11 . The wearable automatic injection device of  claim 1 , wherein the bulk intermediate medicament is coated on an inner surface of the container. 
     
     
         12 . The wearable automatic injection device of  claim 11 , further comprising a piezoelectric element coupled to the container and energized by the activation mechanism when the mixing mechanism is initiated, the piezoelectric element configured to cause the diluent to cavitate or the bulk intermediate medicament to fracture and to release from the container surface into the diluent. 
     
     
         13 . The wearable automatic injection device of  claim 1 , wherein the intermediate container comprises a barrier having an orifice axially disposed in the container. 
     
     
         14 . The wearable automatic injection device of  claim 1 , wherein the intermediate container comprises a porous element having the bulk intermediate medicament within, disposed at a proximal end of the intermediate container. 
     
     
         15 . The wearable automatic injection device of  claim 1 , wherein the intermediate container comprises an impeller to cause oscillation of the diluent in the intermediate container. 
     
     
         16 . The wearable automatic injection device of  claim 1 , wherein the mixing chamber comprises an impeller to cause oscillation of the diluent in the mixing chamber. 
     
     
         17 . A system for administering a final medicament to a patient, the system comprising:
 a mixing mechanism for mixing a bulk intermediate medicament and a diluent to form the final medicament prior to injection; and   a wearable automatic injection device separate from the mixing mechanism comprising:
 a housing; 
 a primary container to hold the final medicament; 
 an injection assembly for injecting the patient with the final medicament; and 
 an activation mechanism for initiating the injection assembly for administering the final medicament to the patient. 
   
     
     
         18 . The system of  claim 17 , wherein the mixing mechanism is configured to store the bulk intermediate medicament and the diluent separately. 
     
     
         19 . The system of  claim 17 , wherein the mixing mechanism comprises a vortex generator having the bulk intermediate medicament coated on the inner surface, the vortex generator configured to receive the diluent from an inlet and generate a vortex movement to mix the bulk intermediate medicament and diluent to form the final medicament. 
     
     
         20 . The system of  claim 19  wherein inert solid beads are entrained in the fluid vortex and their motion against the mixing container walls serves to mechanically disperse and grind the bulk intermediate medicament. 
     
     
         21 . The system of  claim 17 , wherein the mixing mechanism includes a venturi system configured to mix the bulk intermediate medicament and the diluent using a reduction in fluid pressure in the system. 
     
     
         22 . The system of  claim 17 , wherein the mixing mechanism comprises a piezoelectric element that is energized by the mixing mechanism when the mixing mechanism is initiated, the piezoelectric element configured to cause the diluent to cavitate and mix with the bulk intermediate medicament. 
     
     
         23 . The system of  claim 17 , wherein the bulk intermediate medicament is coated on an inner surface of the primary container. 
     
     
         24 . The system of  claim 23 , wherein the mixing mechanism comprises a piezoelectric element coupled to the primary container and is energized by the mixing mechanism when the mixing mechanism is initiated, the piezoelectric element configured to cause the diluent to cavitate or the bulk intermediate medicament to fracture and to release from the inner surface of the primary container into the diluent. 
     
     
         25 . The system of  claim 17 , wherein the mixing mechanism is an electromechanical mixing mechanism. 
     
     
         26 . A wearable automatic injection device for administering a final medicament to a patient, the wearable automatic injection device comprising:
 a housing including:
 a chamber for holding a bulk intermediate medicament and a diluent; and 
 a mixing mechanism operatively coupled to the chamber for mixing the bulk intermediate medicament and the diluent. 
   
     
     
         27 . The wearable automatic injection device of  claim 20 , wherein the chamber includes a first compartment for holding the bulk intermediate medicament and a second compartment for holding the diluent. 
     
     
         28 . The wearable automatic injection device of  claim 21 , wherein the first compartment and the second compartment are initially sealed and separated from each other. 
     
     
         29 . The wearable automatic injection device of  claim 26 , wherein the first compartment and the second compartment are in fluidic communication with each other. 
     
     
         30 . A wearable automatic injection device for administering a final medicament to a patient, the wearable automatic injection device comprising:
 a housing including:
 a chamber for holding a bulk intermediate medicament and a diluent; 
 a fluid pathway extending between the chamber and a delivery cannula; and 
 a mixing mechanism operatively coupled to the fluid pathway for mixing the bulk intermediate medicament and the diluent flowing through the fluid pathway. 
   
     
     
         31 . The wearable automatic injection device of  claim 30 , wherein the chamber includes a first compartment for holding the bulk intermediate medicament and a second compartment for holding the diluent. 
     
     
         32 . The wearable automatic injection device of  claim 31 , wherein the first compartment and the second compartment are initially sealed and separated from each other. 
     
     
         33 . The wearable automatic injection device of  claim 32 , wherein the first compartment and the second compartment are in fluidic communication with each other. 
     
     
         34 . The wearable automatic injection device of any one of  claim 1  further comprising:
 a vibration mechanism coupled to the housing, that when activated, causes the wearable automatic injection device to vibrate against the patient's skin during an injection to distract the patient from pain caused by the injection. 
 
     
     
         35 . The wearable automatic injection device of  claim 30 , further comprising:
 a pressure sensor coupled to the housing to detect contact between the wearable injection device and the patient's skin.   
     
     
         36 . The wearable automatic injection device of any one of  claim 1  further comprising:
 a cooling mechanism coupled to the housing, that when activated, causes cooling of the wearable automatic injection device before an injection to distract the patient from pain caused by the injection. 
 
     
     
         37 . The wearable automatic injection device of  claim 36 , further comprising:
 a pressure sensor coupled to the housing to detect contact between the wearable injection device and the patient's skin.   
     
     
         38 . The wearable automatic injection device of  claim 36 , further comprising:
 a temperature sensor coupled to the housing to detect a temperature of the wearable injection device.