Macrophages/microglia in neuro-inflammation associated with neurodegenerative diseases

Abstract

Described herein are methods of treating neuron inflammation conditions, for example, Alzheimer's disease, Parkinson's disease, Huntington's disease, ischemic stroke, and prion disease, comprising administering a therapeutically effective amount of cromolyn or a cromolyn derivative compound.

1 . A method of treating a neuron inflammation condition in a patient in need thereof comprising administering to the patient a therapeutically effective amount of at least one compound having the following formula: 
       
         
           
           
               
               
           
         
         provided the compound is not cromolyn disodium, 
       
       
         
           
           
               
               
           
         
         when the neuron inflammation condition is Alzheimer's Disease (AD). 
       
     
     
         2 . The method according to  claim 1 , wherein the compound has the following formula 
       
         
           
           
               
               
           
         
         
           
           
               
               
           
         
       
     
     
         3 . The method of  claim 1 , wherein the neuron inflammation condition is amyotrophic lateral scerlosis (ALS). 
     
     
         4 . The method of  claim 1 , wherein the neuron inflammation condition is AD. 
     
     
         5 . The method of  claim 1 , wherein the neuron inflammation is Huntington's Disease. 
     
     
         6 . The method of  claim 1 , wherein the neuron inflammation is Parkinson's disease (PD). 
     
     
         7 . The method of  claim 1 , wherein the neuron inflammation condition is ischemic stroke. 
     
     
         8 . The method of  claim 1 , wherein the neuron inflammation condition is associated with prion disease. 
     
     
         9 - 13 . (canceled) 
     
     
         14 . The method of  claim 3 , further comprising co-administering a second compound selected from CD4+; siRNA; miRNA that ameliorates ALS; glial morphology modifier; SOD1 control; and Riluzole. 
     
     
         15 . The method of  claim 3 , further comprising co-administering a second compound selected from an anti-aggregation drug and a targeting drug for AD. 
     
     
         16 . The method of  claim 1 , wherein the neuron inflammation condition is AD, further comprising co-administering a second compound selected from an antibody targeting drug that ameliorates AD. 
     
     
         17 . The method of  claim 1 , wherein the neuron inflammation condition is AD, further comprising co-administering a second compound selected from an anti-inflammatory targeting drug that ameliorates AD. 
     
     
         18 . The method of  claim 1 , wherein the neuron inflammation condition is AD, further comprising co-administering a second compound selected from a tau targeting drug that ameliorates AD. 
     
     
         19 . The method of  claim 3 , further comprising co-administering a second compound selected from an antibody targeting drug that ameliorates ALS. 
     
     
         20 . The method of  claim 3 , further comprising co-administering a second compound selected from an anti-inflammatory targeting drug that ameliorates ALS. 
     
     
         21 . The method of  claim 1 , further comprising co-administering a second compound selected from a targeting drug that ameliorates neurodegeneration associated with amyloidosis or tauopathies. 
     
     
         22 . The method of  claim 6 , further comprising co-administering a second compound selected from an alpha synuclein targeting drug that ameliorates PD and a Parkinson's targeting drug that ameliorates PD. 
     
     
         23 . The method of  claim 3 , wherein the compound is cromolyn disodium. 
     
     
         24 . The method of  claim 5 , wherein the compound is cromolyn disodium. 
     
     
         25 . The method of  claim 6 , wherein the compound is cromolyn disodium.