Heterocyclic substituted-3-heteroarylidenyl-2-indolinone derivative

Abstract

Disclosed is a compound represented by formula (1) or a pharmacologically acceptable salt thereof. (In the formula, R 1 is optionally substituted heteroaryl etc.; R 2 is hydrogen etc.; R 3 and R 4 are each independently hydrogen etc., R 5 is the following group: (wherein Y is optionally substituted five membered heteroaryl etc., R 9a is optionally substituted aryl etc., R 9b and R 9c are each dependently hydrogen etc., and m is the integral 0 etc.) etc.; R 6 is hydrogen etc.; and R 7 is hydrogen etc.

1 . A compound of formula 1: 
       
         
           
           
               
               
           
         
         or pharmaceutically acceptable salt thereof, 
         R 1  is optionally substituted heteroaryl, or optionally substituted heteroalicyclic: 
         R 2  is hydrogen, optionally substituted alkyl, optionally substituted alkylcarbonyl, 
         optionally substituted alkoxycarbonyl, or optionally substituted aminocarbonyl; 
         R 3  and R 4  are each independently hydrogen, halogen, cyano, nitro, hydroxy, optionally 
         substituted alkyl, optionally substituted alkoxy, optionally substituted amino, optionally substituted alkoxycarbonyl, optionally substituted alkylcarbonyl, optionally substituted aminocarbonyl, or the following group: 
       
       
         
           
           
               
               
           
         
         (wherein 
         X is optionally substituted five membered heteroaryl or optionally substituted heteroalicyclic, 
         R 8a  is optionally substituted aryl, optionally substituted heteroaryl, or optionally substituted heteroalicyclic, 
         R 8b  and R 8c  are each independently hydrogen, alkyl, halogen, cyano, amino, nitro, hydroxy, trifluoromethyl, optionally substituted aryl, optionally substituted heteroaryl, or optionally substituted heteroalicyclic, and 
         n is the integral 0 to 2), 
         R 5  is hydrogen, halogen, cyano, nitro, hydroxy, optionally substituted alkyl, optionally substituted alkoxy, optionally substituted amino, optionally substituted alkoxycarbonyl, optionally substituted alkylcarbonyl, optionally substituted aminocarbonyl, or the following group: 
       
       
         
           
           
               
               
           
         
         (wherein 
         Y is optionally substituted five membered heteroaryl (provided that the five membered heteroaryl is not the following group: 
       
       
         
           
           
               
               
           
         
         wherein R 9a  is same as the above definition), 
         R 9a  is optionally substituted aryl, optionally substituted heteroaryl, or optionally substituted heteroalicyclic, 
         R 9b  and R 9c  are each dependently hydrogen, alkyl, halogen, cyano, amino, nitro, hydroxy, trifluoromethyl, and 
         m is the integral 0 to 2), and 
         at least one of R 3 , R 4  and R 5  is the following group: 
       
       
         
           
           
               
               
           
         
         (X, R 8a , R 8b , R 8c  and n are same as the above definition), or the following group: 
       
       
         
           
           
               
               
           
         
         (Y, R 9a , R 9b , R 9c  and m are same as the above definition); 
         R 6  is hydrogen, halogen, cyano, nitro, hydroxy, amino, optionally substituted alkyl, optionally substituted alkoxy, optionally substituted amino, optionally substituted alkoxycarbonyl, optionally substituted alkyl carbonyl, or optionally substituted aminocarbonyl; and 
         R 7  is hydrogen, optionally substituted alkyl, or optionally substituted cycloalkyl.