US2019247510A1PendingUtilityA1
Dll3 modulators and methods of use
Est. expiryFeb 24, 2032(~5.6 yrs left)· nominal 20-yr term from priority
A61P 35/00A61P 11/00G01N 33/5759G01N 33/5752A61K 47/50A61K 45/06A61K 47/6809A61K 47/6825C07K 16/28A61K 2039/505C07K 2317/34C07K 2317/21C07K 2317/33C07D 487/16C07K 16/18G01N 2333/70596A61K 47/6867A61K 47/6889A61K 47/6849C07K 16/30C07K 2317/622A61K 47/6855C07K 2317/70C07D 487/04A61K 47/6857C07K 2317/24C07K 2317/626A61K 31/551A61K 47/6891A61K 51/1096A61K 47/6861C07K 16/3023C07K 2317/31A61K 31/5517C07K 2317/565C07K 2317/92C07K 2317/20A61K 47/6869A61K 47/6859C07K 16/3069A61K 47/6843A61K 2039/572C07K 2317/77A61K 47/6851C07K 2317/76C07K 16/2809A61K 47/6813C07K 2317/732C07K 2317/53A61K 39/3955C07K 2317/55A61K 47/6829C07K 14/47C07K 2319/30C07K 2317/73A61K 47/6865A61K 47/6811C07K 2317/56C07K 2317/35C07K 2317/54A61K 47/6803G01N 33/57423G01N 33/57492A61K 47/68035
77
PatentIndex Score
0
Cited by
0
References
0
Claims
Abstract
Novel modulators, including antibodies and derivatives thereof, and methods of using such modulators to treat proliferative disorders are provided.
Claims
exact text as granted — not AI-modified1 .- 20 . (canceled)
21 . A nucleic acid encoding a humanized light chain variable region, wherein the light chain variable region is 70% identical to SEQ ID NO: 30.
22 . The nucleic acid of claim 21 , wherein the light chain variable region is 80% identical to SEQ ID NO: 30.
23 . The nucleic acid of claim 21 , wherein the light chain variable region is 90% identical to SEQ ID NO: 30.
24 . The nucleic acid of claim 21 , wherein the light chain variable region is 100% identical to SEQ ID NO: 30.
25 . A vector comprising the nucleic acid of claim 21 .
26 . A vector comprising the nucleic acid of claim 22 .
27 . A vector comprising the nucleic acid of claim 23 .
28 . A vector comprising the nucleic acid of claim 24 .
29 . A host cell comprising the nucleic acid of claim 21 .
30 . A host cell comprising the vector of claim 25 .
31 . A nucleic acid encoding a humanized heavy chain variable region, wherein the heavy chain variable region is 70% identical to SEQ ID NO: 31.
32 . The nucleic acid of claim 31 , wherein the heavy chain variable region is 80% identical to SEQ ID NO: 31.
33 . The nucleic acid of claim 31 , wherein the heavy chain variable region is 90% identical to SEQ ID NO: 31.
34 . The nucleic acid of claim 31 , wherein the heavy chain variable region is 100% identical to SEQ ID NO: 31.
35 . A vector comprising the nucleic acid of claim 31 .
36 . A vector comprising the nucleic acid of claim 32 .
37 . A vector comprising the nucleic acid of claim 33 .
38 . A vector comprising the nucleic acid of claim 34 .
39 . A host cell comprising the nucleic acid of claim 31 .
40 . A host cell comprising the vector of claim 35 .Cited by (0)
No later patents cite this yet.
References (0)
No backward citations on record.