US2019254276A1PendingUtilityA1

Glycols as pathogen inactivating agents

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Assignee: LAB FRANCAIS DU FRACTIONNEMENTPriority: Dec 30, 2010Filed: Oct 17, 2018Published: Aug 22, 2019
Est. expiryDec 30, 2030(~4.4 yrs left)· nominal 20-yr term from priority
Inventors:Sami Chtourou
A61L 2103/09A61L 2/18A61L 2103/05A01N 31/02A61L 2202/22A61L 2/0088A01N 1/10A23B 2/70A61L 2/16
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Claims

Abstract

The disclosure relates to uses, methods and compositions for the inactivation of pathogens in biological compositions, using a glycol as a pathogen inactivating agent.

Claims

exact text as granted — not AI-modified
What is claimed is: 
     
         1 . (canceled) 
     
     
         2 . (canceled) 
     
     
         3 . A method for inactivating a pathogen in a biological composition, said method comprising contacting said biological composition with a glycol to inactivate the pathogen. 
     
     
         4 . The method of  claim 3 , wherein said glycol is propylene glycol. 
     
     
         5 . The method of  claim 3 , wherein said biological composition is a blood composition or a milk composition. 
     
     
         6 . The method of  claim 3 , wherein said pathogen is selected from the group consisting of viruses, bacteria, fungi, protozoa, parasites, and prions. 
     
     
         7 . The method of  claim 6 , wherein said virus is selected from the group consisting of X-MuLV, PRV, BVDV and TGEV virus. 
     
     
         8 . The method of  claim 3 , wherein said method results in a pathogen elimination equal or greater than 4 Log 10  TCID (Tissue Culture Infective Dose), wherein the TCID is according to the methods of Kärber and/or Spearman-Kärber. 
     
     
         9 . The method of  claim 3 , wherein the concentration of glycol after the contacting step is between 40 and 50% (v/v) of the biological composition. 
     
     
         10 . The method of  claim 3 , wherein said method is performed at a temperature between 15 and 25° C. 
     
     
         11 . The method of  claim 3 , wherein said method is performed at a pH between 7.0 and 8.0. 
     
     
         12 . A biological composition comprising glycol, wherein the biological composition is obtained by the method of  claim 3 . 
     
     
         13 . The biological composition of  claim 12 , wherein said glycol is at a concentration between 40 and 50% (v/v). 
     
     
         14 . The biological composition of  claim 12 , wherein said glycol is propylene glycol.

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