Delivery devices containing encapsulated and/or particle-bound active pharmaceutical ingredients

Abstract

Delivery devices of a degradable or nondegradable biocompatible matrix with one or more encapsulated active pharmaceutical ingredients or one or more particle-bound active pharmaceutical ingredients dispersed in the matrix are provided. Also provided are methods for delivering an active pharmaceutical ingredient to a subject with these delivery devices. Modified vaginal rings are also provided as well as surface coatings for delivery devices which minimize bio-interaction of the coated delivery devices.

What is claimed is: 
     
         1 . A vaginal ring comprising a ring body with an irregular surface to increase surface area of the vaginal ring. 
     
     
         2 . The vaginal ring of  claim 1  wherein the irregular surface of the vaginal ring is dimpled or divetted. 
     
     
         3 . The vaginal ring of  claim 2  wherein the dimples or divets are filled with an active pharmaceutical ingredient-containing matrix. 
     
     
         4 . A surface coating which minimizes bio-interaction of a delivery device for an activated pharmaceutical ingredient, said surface coating comprising one or more anionic or nonionic hydrophilic polymers which is applied as a coating to a delivery device.