Immunogenic Influenza Composition

Abstract

Novel compositions useful as influenza immunogens are provided. The compositions enable a host response to immunogen sites normally not recognized by a host.

1 - 10 . (canceled) 
     
     
         11 . A method of generating an immune response reactive with more than two serotypes of influenza virus comprising administering to a host an isolated composition comprising a dampened immunodominant epitope and an immunogenic subdominant epitope, wherein said antibody binds said subdominant epitope on said more than two serotypes of influenza virus. 
     
     
         12 . The method of  claim 11 , wherein said immunodominant epitope comprises a hemagglutinin. 
     
     
         13 . The method of  claim 11 , wherein said immunodominant epitope comprises a neuraminidase. 
     
     
         14 . The method of  claim 11 , wherein said immunodominant epitope comprises addition or removal of a glycosylation site. 
     
     
         15 . The method of  claim 11 , wherein said immunodominant epitope comprises an amino acid addition, an amino acid substitution or an amino acid deletion. 
     
     
         16 . The method of  claim 11 , wherein said immunodominant epitope comprises more than one mutation. 
     
     
         17 . The method of  claim 11 , wherein said immunodominant epitope comprises a change to an amino acid. 
     
     
         18 . The method of  claim 11 , wherein said composition comprises an influenza virus particle. 
     
     
         19 . The method of  claim 11 , wherein said composition comprises a virus-like particle. 
     
     
         20 . The method of  claim 11 , wherein said composition is expressed on the surface of an influenza virus. 
     
     
         21 . The method of  claim 11 , wherein said composition comprises an immunogenic composition. 
     
     
         22 . The method of  claim 11 , wherein said composition further comprises a pharmaceutically acceptable carrier, excipient or diluent. 
     
     
         23 . The method of  claim 11 , wherein said composition comprises a nucleic acid encoding said immunodominant epitope. 
     
     
         24 . The method of  claim 11 , wherein said composition comprises a polypeptide comprising said immunodominant epitope. 
     
     
         25 . The method of  claim 11 , wherein said composition comprises a recombinant virus. 
     
     
         26 . The method of  claim 11 , wherein said host comprises an animal. 
     
     
         27 . The method of  claim 11 , wherein said influenza virus comprises an influenza A. 
     
     
         28 . The method of  claim 11 , wherein said administering occurs before said host comprises an influenza disease. 
     
     
         29 . The method of  claim 11 , wherein said immune response comprises antibody. 
     
     
         30 . The method of  claim 29 , further comprising isolating said antibody.