Antimicrobial compositions and methods of making the same

Abstract

The present disclosure comprises antimicrobial compositions and devices comprising silver compounds that resist heat and light discoloration. In one aspect, the said compounds comprise silver and at least one s-triazine ring or moiety. In another aspect, the antimicrobial compositions are hydrogels that are effective against broad spectrum of common pathogens including MRSA and VRE and are suitable for treating human or animal wounds and burns. The methods of the present disclosure comprise treating medical and non-medical devices and articles with compositions comprising the silver compounds to impart antimicrobial property.

1 . A method of disinfecting or preventing/inhibiting growth of microorganisms in a liquid comprising the steps of:
 preparing an aqueous concentrate comprising a photoreduction resistant silver cyanurate compound wherein the silver cyanurate compound is one or more of photoreduction resistant monosilver cyanurate (C3N3H2O3Ag) or its hydrate, photoreduction resistant disilver cyanurate (C3N3HO3Ag2) or its hydrate, photoreduction resistant C3N3O3Ag2X or its hydrate, photoreduction resistant C3N3HO3AgX or its hydrate, and/or photoreduction resistant X[Ag(C3N3H2O3)2] or its hydrate, where X is one of potassium, sodium, calcium, magnesium, or ammonium, and where the photoreduction resistant antimicrobial compound is photoreduction resistant for a period of at least thirty days; and   adding the aqueous concentrate to the liquid.   
     
     
         2 . The method of  claim 1 , wherein the aqueous concentrate is inert to heat. 
     
     
         3 . The method of  claim 1 , wherein the aqueous concentrate is inert to light. 
     
     
         4 . The method of  claim 1 , wherein an amount of silver in the liquid is between 0.0001% and 1.0% by weight of the liquid. 
     
     
         5 . The method of  claim 1 , wherein the liquid is water; and
 wherein adding the aqueous concentrate renders the liquid potable.   
     
     
         6 . The method of  claim 1 , wherein the liquid is a contact lens solution. 
     
     
         7 . The method of  claim 1 , wherein the aqueous concentrate is sterile. 
     
     
         8 . The method of  claim 1 , wherein the microorganisms are one of bacteria, yeast, fungi and amoeba. 
     
     
         9 . A method of imparting antimicrobial property to a fibrous material comprising the steps of:
 (i) preparing an antimicrobial composition comprising a silver cyanurate compound wherein the silver cyanurate compound is one or more of photoreduction resistant monosilver cyanurate (C3N3H2O3Ag) or its hydrate, photoreduction resistant disilver cyanurate (C3N3HO3Ag2) or its hydrate, photoreduction resistant C3N3O3Ag2X or its hydrate, photoreduction resistant C3N3HO3AgX or its hydrate, and/or photoreduction resistant X[Ag(C3N3H2O3)2] or its hydrate, where X is one of potassium, sodium, calcium, magnesium, or ammonium, and where the photoreduction resistant antimicrobial compound is photoreduction resistant for a period of at least thirty days and wherein the antimicrobial composition is inert to one or more of heat and light;   (ii) immersing the fibrous material into the antimicrobial composition to effect absorption of the antimicrobial composition into the fibrous material; and   (iii) drying the fibrous material.   
     
     
         10 . The method of  claim 9 , wherein an amount of silver in the antimicrobial composition is between 0.0001% and 1% by weight of the antimicrobial composition. 
     
     
         11 . The method of  claim 9 , further comprising wetting the fibrous material with water or a mixture of water and a non-aqueous solvent prior to immersing the fibrous material into the antimicrobial composition. 
     
     
         12 . The method of  claim 9 , wherein the fibrous material is a synthetic material. 
     
     
         13 . The method of  claim 9 , wherein the fibrous material is a woven fibrous material or a non-woven fibrous material. 
     
     
         14 . The method of  claim 9 , wherein the antimicrobial composition is diluted with aqueous ammonia prior to immersing the fibrous material into the antimicrobial composition. 
     
     
         15 . The method of  claim 9 , wherein the antimicrobial composition is diluted with a non-aqueous solvent or a mixture of a water miscible non-aqueous solvent and water prior to immersing the fibrous material into the antimicrobial composition. 
     
     
         16 . The method of  claim 15 , wherein the non-aqueous solvent and the water miscible non-aqueous solvent is one of acetone, THF and lower alkyl (C1-C6) alcohols. 
     
     
         17 . A device comprising a silver cyanurate compound possessing antimicrobial activity, where the silver cyanurate compound is photoreduction resistant for a period of at least thirty days. 
     
     
         18 . The device of  claim 17 , wherein the silver cyanurate compound is one of blended into a surface coating of the device, dip-coated onto a surface of the device, brushed onto the surface of the device and sprayed onto the surface of the device. 
     
     
         19 . The device of  claim 17 , wherein the silver cyanurate compound is one or more of photoreduction resistant monosilver cyanurate (C3N3H2O3Ag) or its hydrate, photoreduction resistant disilver cyanurate (C3N3HO3Ag2) or its hydrate, photoreduction resistant C3N3O3Ag2X or its hydrate, photoreduction resistant C3N3HO3AgX or its hydrate, and/or photoreduction resistant X[Ag(C3N3H2O3)2] or its hydrate, where X is one of potassium, sodium, calcium, magnesium, or ammonium. 
     
     
         20 . The device of  claim 17 , wherein the device has a silver content of between 0.0001% and 10% by weight of the device.