Use of akkermansia for treating metabolic disorders

Abstract

The present invention relates to Akkermansia muciniphila or fragments thereof for treating a metabolic disorder in a subject in need thereof. The present invention also relates to a composition, a pharmaceutical composition and a medicament comprising Akkermansia muciniphila or fragments thereof for treating a metabolic disorder. The present invention also relates to the use of Akkermansia muciniphila or fragments thereof for promoting weight loss in a subject in need thereof.

1 - 17 . (canceled) 
     
     
         18 . A food product comprising  Akkermansia muciniphila  or fragments thereof. 
     
     
         19 . The food product according to  claim 18 , wherein said food product is in form of liquid food, solid food, feed or drinking water. 
     
     
         20 . The food product according to  claim 18 , wherein said food product is in form of a dairy product, a dairy drink, a yogurt, a drinking yoghurt, a cheese, a fruit or vegetable juice or concentrate thereof, powders, a malt or soy or cereal based beverage, breakfast cereal such as muesli flakes, fruit and vegetable juice powders, a cereal and/or chocolate bar, confectionary, spreads, a flour, milk, a smoothie, a milk product, a milk powder, a reconstituted milk, a cultured milk, set yoghurt, drink, milk drink, chocolate, gels, an ice cream, cereals, a reconstituted fruit product, a snack bar, a food bar, a muesli bar, a sauce, a dip, and a drink including dairy and non-dairy based drinks, sports supplements including dairy and non-dairy sports supplements. 
     
     
         21 . The food product according to  claim 18 , wherein said food product is an animal food product. 
     
     
         22 . A food additive comprising  Akkermansia muciniphila  or fragments thereof. 
     
     
         23 . The food additive according to  claim 22 , wherein said food additive is a human food additive. 
     
     
         24 . The food additive according to  claim 22 , wherein said food additive is an animal food additive. 
     
     
         25 . A nutritional composition comprising  Akkermansia muciniphila  or fragments thereof. 
     
     
         26 . The nutritional composition according to  claim 25 , wherein said nutritional composition comprises liquid or solid food, feed or drinking water. 
     
     
         27 . The nutritional composition according to  claim 25 , comprising viable cells of  Akkermansia muciniphila.    
     
     
         28 . A nutritional additive comprising  Akkermansia muciniphila  or fragments thereof. 
     
     
         29 . A probiotic comprising  Akkermansia muciniphila.    
     
     
         30 . The probiotic according to  claim 29  comprising from about 1·10 4  to about 1·10 12  cfu of  Akkermansia muciniphila.    
     
     
         31 . A method for promoting weight loss in a subject comprising administering a food product, a nutritional composition or a probiotic comprising  Akkermansia muciniphila  or fragments thereof to the subject. 
     
     
         32 . The method according to  claim 31 , wherein said food product or nutritional composition is in the form of liquid food, solid food, feed or drinking water. 
     
     
         33 . The method according to  claim 31 , wherein said food product or nutritional composition is in form of a dairy product, a dairy drink, a yogurt, a drinking yoghurt, a cheese, a fruit or vegetable juice or concentrate thereof, powders, a malt or soy or cereal based beverage, breakfast cereal such as muesli flakes, fruit and vegetable juice powders, a cereal and/or chocolate bar, confectionary, spreads, a flour, milk, a smoothie, a milk product, a milk powder, a reconstituted milk, a cultured milk, set yoghurt, drink, milk drink, chocolate, gels, an ice cream, cereals, a reconstituted fruit product, a snack bar, a food bar, a muesli bar, a sauce, a dip, and a drink including dairy and non-dairy based drinks, sports supplements including dairy and non-dairy sports supplements. 
     
     
         34 . The method according to  claim 31 , wherein said food product or nutritional composition is co-administered with another probiotic strain and/or with one or more prebiotics. 
     
     
         35 . A method for increasing satiety or for increasing energy expenditure in a subject comprising administering a food product, a nutritional composition or a probiotic comprising  Akkermansia muciniphila  or fragments thereof to the subject. 
     
     
         36 . The method according to  claim 35 , wherein said food product or nutritional composition is in form of a dairy product, a dairy drink, a yogurt, a drinking yoghurt, a cheese, a fruit or vegetable juice or concentrate thereof, powders, a malt or soy or cereal based beverage, breakfast cereal such as muesli flakes, fruit and vegetable juice powders, a cereal and/or chocolate bar, confectionary, spreads, a flour, milk, a smoothie, a milk product, a milk powder, a reconstituted milk, a cultured milk, set yoghurt, drink, milk drink, chocolate, gels, an ice cream, cereals, a reconstituted fruit product, a snack bar, a food bar, a muesli bar, a sauce, a dip, and a drink including dairy and non-dairy based drinks, sports supplements including dairy and non-dairy sports supplements. 
     
     
         37 . The method according to  claim 35 , wherein said food product or nutritional composition is co-administered with another probiotic strain and/or with one or more prebiotics.