Sugar compositions for tableting by direct compression

Abstract

Directly compressible compositions that include more than 30% by weight of allulose, and tablets obtainable thereof.

1 . A directly compressible composition comprising allulose as a direct compression excipient. 
     
     
         2 . The directly compressible composition of  claim 1 , wherein the allulose is present in an amount effective to be used as a sweetener. 
     
     
         3 . The directly compressible composition of  claim 1 , wherein allulose is present in an amount effective to be used as a health ingredient providing physiological functions. 
     
     
         4 . Allulose which is compressible in the sole presence of a lubricant, to form a tablet having a diameter of 13 mm, a weight of 800+/−5 mg, a cylindrical shape with convex faces with a radius of curvature of 13 mm, whose hardness is greater than 50 N at at least one compression force ranging from 5 to 20 kN, the ejection force being lower than 1200 N. 
     
     
         5 . The allulose of  claim 4 , wherein said allulose is crystalline allulose. 
     
     
         6 . The allulose according to  claim 4 , wherein said allulose has mean volume diameter D 4,3 greater than 45 μm and equal to or lower than 310 μm. 
     
     
         7 . The allulose according to  claim 4 , wherein said allulose has a bulk density between 0.50 to 1.10 g/mL. 
     
     
         8 . The allulose according to  claim 4 , wherein said allulose has a tapped density between 0.60 to 1.20 g/mL. 
     
     
         9 . A directly compressible composition comprising allulose, wherein said allulose represents at least 30% of said directly compressible composition, said percentage being expressed in dry weight with respect to the total dry weight of said directly compressible composition. 
     
     
         10 . The directly compressible composition of  claim 9 , comprising no more than 60% of direct compression excipient other than allulose, said percentage being expressed in dry weight, with respect to the total dry weight of said directly compressible composition. 
     
     
         11 . A method for the manufacture of a tablet, comprising the steps of:
 providing a directly compressible composition according to  claim 9 ; and   directly compressing the composition to form the tablet.   
     
     
         12 . A tablet comprising allulose, wherein allulose represents at least 30% of said tablet, said percentage being expressed in dry weight with respect to the total dry weight of said tablet. 
     
     
         13 . The tablet of  claim 12 , wherein said tablets comprises no more than 60% of direct compression excipient other than allulose, said percentage being expressed in dry weight with respect to the total dry weight of said tablet. 
     
     
         14 . The tablet according to  claim 12 , wherein said tablet is a sweet tablet, having caloric value lower than 5 kcal/g. 
     
     
         15 . The tablet according to  claim 12 , having hardness greater than 50 N. 
     
     
         16 . A process for the manufacture of allulose, comprising:
 a step (a) of providing allulose obtained by crystallization in water or in a mixture of ethanol and water;   a step (b) of grinding allulose obtained in step (a);   a step (c) of sieving the allulose obtained in step (b), so as to obtain allulose having mean volume diameter D 4,3 greater than 45 μm and equal to or lower than 310 μm;   a step (d) of recovering the allulose obtained in step (c).   
     
     
         17 . The process according to  claim 16 , wherein said allulose is compressible in the sole presence of a lubricant, to form a tablet having a diameter of 13 mm, a weight of 800+/−5 mg, a cylindrical shape with convex faces with a radius of curvature of 13 mm, whose hardness is greater than 50 N at at least one compression force ranging from 5 to 20 kN, the ejection force being lower than 1200 N. 
     
     
         18 . The process according to  claim 16 , wherein said allulose has mean volume diameter D 4,3 greater than 45 μm and equal to or lower than 310 μm. 
     
     
         19 . The process according to  claim 16 , wherein said allulose has a bulk density between 0.50 to 1.10 g/mL.