Materials and methods for treatment of inflammation

Abstract

The subject invention pertains to peptides and salts thereof that are useful as anti-inflammatory agents and to compositions containing such peptides and salts as active ingredients. Specifically exemplified herein are endomorphin-1 peptide (EM-1), analogs and salts thereof, and uses for modulation of calcitonin gene-related peptide (CGRP) production and/or substance P (SP) and for treatment of inflammation, particularly neurogenic inflammation.

We claim: 
     
         1 . A composition comprising SEQ ID NO: 13 and hydroxypropyl-3 cyclodextrin (HPCD) in water. 
     
     
         2 . The composition, according to  claim 1 , wherein the concentration of HPCD is about 20% and the water is sterile distilled water. 
     
     
         3 . The composition, according to  claim 1 , wherein the composition is clear. 
     
     
         4 . The composition, according to  claim 1 , which is a solution. 
     
     
         5 . The composition, according to  claim 1 , further comprising acetate ions. 
     
     
         6 . A method for treating a human subject to reduce inflammation and/or modulate an immune response, wherein said method comprises administering to a human subject in need of such treatment, an effective amount of the composition of  claim 1 . 
     
     
         7 . The method, according to  claim 6 , further comprising administering an anti-inflammatory agent selected from the group consisting of a steroidal compound, hydrocortisone, a non-steroidal anti-inflammatory compound, acetylsalicylic acid (aspirin), ibuprofen, acetaminophen, and indomethacin.