Tissue-Adhesive Material

Abstract

The invention is directed to a tissue-adhesive polymer blend comprising a bioresorbable carrier polymer and a bioresorbable synthetic tissue-reactive polymer as well as to a tissue-adhesive device for sealing dura mater comprising said tissue-adhesive polymer blend.

1 .- 17 . (canceled) 
     
     
         18 . A tissue-adhesive polymer blend comprising a bioresorbable carrier polymer and a bioresorbable synthetic tissue-reactive polymer, wherein the synthetic tissue-reactive polymer is based on a multi-arm polyethylene glycol and is functionalized with at least one tissue-reactive group that comprises an activated ester, wherein the tissue-reactive polymer has a molecular weight of 20000 g/mol or more. 
     
     
         19 . Tissue-adhesive polymer blend according to  claim 18 , wherein the carrier polymer is a synthetic carrier polymer comprising polyesters, polyethers, polyhydroxyacids, polylactones, polyetheresters, polycarbonates, polydioxanes, polyanhydrides, polyurethanes, polyester(ether)urethanes, polyurethane urea, polyamides, polyesteramides, poly-orthoesters, polyaminoacids, polyphosphonates, polyphosphazenes and combinations thereof. 
     
     
         20 . Tissue-adhesive polymer blend according to  claim 19 , wherein the synthetic carrier polymer comprises a poly(DL-lactide-co-ε-caprolactone) copolymer obtainable by the copolymerizaton of DL-lactide and ε-caprolactone. 
     
     
         21 . Tissue-adhesive polymer blend according to  claim 18 , wherein the carrier polymer is a biological polymer comprising a polysaccharide. 
     
     
         22 . Tissue-adhesive polymer blend according to  claim 18 , wherein the activated ester is selected from the group consisting of a thioester, a perfluoroalkyl ester, pentafluorophenol ester, N-hydroxysuccinimide ester and derivatives thereof. 
     
     
         23 . Tissue-adhesive polymer blend according to  claim 18 , wherein the tissue-reactive polymer is based on a 4-arm or an 8-arm polyethylene glycol. 
     
     
         24 . Tissue-adhesive polymer blend according to  claim 18 , wherein the tissue-reactive polymer has a molecular weight of up to to 100000 g/mol. 
     
     
         25 . Tissue-adhesive polymer blend  claim 18 , wherein the weight ratio of the carrier polymer to the tissue-reactive polymer in the material is 1:10 to 10:1. 
     
     
         26 . Tissue-adhesive polymer blend according to  claim 18 , further comprising a filler polymer that is typically based on polyethylene glycol that is not functionalized with the tissue-reactive functional group. 
     
     
         27 . Tissue-adhesive polymer blend according to  claim 18 , further comprising a buffering agent which is preferably selected from the group consisting of phosphates, carbonates, acetates, citrates, Good's buffers and combinations thereof. 
     
     
         28 . (canceled) 
     
     
         29 . Tissue-adhesive device for sealing dura mater comprising the tissue-adhesive polymer blend in accordance to  claim 18 , preferably having a foam structure, a sheet structure, a gel-like structure or combinations thereof. 
     
     
         30 . Tissue-adhesive device for sealing dura mater according to  claim 29  comprising a foam structure. 
     
     
         31 . Tissue-adhesive device for sealing dura mater according to  claim 29 , having a multilayered structure comprising at least two layers of which a first layer which comprises a foam structure that comprises a tissue-adhesive polymer blend in accordance to  claim 18  and a second layer which comprises a sheet structure. 
     
     
         32 . Tissue-adhesive device for sealing dura mater according to  claim 29 , having a multilayered structure comprising at least two layers of which a first layer comprises a tissue-adhesive polymer blend in accordance to  claim 18  and a second layer essentially consisting of the carrier polymer in accordance to  claim 18 . 
     
     
         33 . Tissue-adhesive device for sealing dura mater according to  claim 29 , having an adhesive strength of more than 1 N. 
     
     
         34 . Tissue-adhesive device for sealing dura mater according to  claim 29 , having a burst-resistance of at least 8 mmHg. 
     
     
         35 . Tissue-adhesive device for sealing dura mater according to  claim 29 , having a burst-resistance of at least 15 mmHg. 
     
     
         36 . Tissue-adhesive device for sealing dura mater according to  claim 29 , having a burst-resistance of at least 30 mmHg. 
     
     
         37 . Tissue-adhesive device for sealing dura mater according to  claim 29 , having a burst-resistance of at least 45 mmHg. 
     
     
         38 . Tissue-adhesive polymer blend according to  claim 24 , wherein the tissue-reactive polymer has a molecular weight of up to to 80000 g/mol. 
     
     
         39 . Tissue-adhesive polymer blend according to  claim 24 , wherein the tissue-reactive polymer has a molecular weight of 20000 to 60000 g/mol. 
     
     
         40 . Tissue-adhesive polymer blend according to  claim 27 , wherein the buffering agent is selected from the group consisting of phosphates, carbonates, acetates, citrates, Good's buffers and combinations thereof. 
     
     
         41 . Method for sealing dura mater of the human body by sealing the dura mater with a tissue-adhesive polymer blend in accordance with  claim 18 .