Methods for treating gi tract disorders

Abstract

Provided herein are methods, compositions, and kits for the treatment of an enteric nervous system disorder. Such methods may comprise administering to a subject an effective amount of a phenothiazine compound, a peripherally restricted dopamine decarboxylase inhibitor, and/or a peripherally restricted dopamine D2 receptor antagonist that does not substantially inhibit hERG channels.

1 . A method of treating an enteric nervous system disorder in a human subject in need thereof, comprising administering to the subject an effective dose of a compound comprising a phenothiazine group or a pharmaceutically acceptable salt, solvate, or metabolite thereof to the subject for over 5 days. 
     
     
         2 . A method of treating an enteric nervous system disorder in a subject in need thereof, comprising administering to the subject an effective dose of a compound comprising a phenothiazine group or a pharmaceutically acceptable salt, solvate, or metabolite thereof to the subject for over 7 days. 
     
     
         3 . A method of treating an enteric nervous system disorder in a subject in need thereof, comprising co-administering to the subject an effective dose of a compound comprising a phenothiazine group or a pharmaceutically acceptable salt, solvate, or metabolite thereof, and a dopamine decarboxylase inhibitor. 
     
     
         4 - 45 . (canceled)