US2019316123A1PendingUtilityA1

Antisense oligonucleotide compositions

70
Assignee: IONIS PHARMACEUTICALS INCPriority: May 17, 2012Filed: Nov 28, 2018Published: Oct 17, 2019
Est. expiryMay 17, 2032(~5.8 yrs left)· nominal 20-yr term from priority
Inventors:Andrew DibbleLloyd TillmanBret A. ColdrenMarc Lim
C12N 2310/11C12N 2320/50C12N 2320/51C12N 2320/52C12N 2310/3231C12N 15/113C12N 2310/321C12N 15/111A61K 31/7115C12N 2310/3525C12N 2310/3341C12N 2310/323C12N 2310/315A61K 31/7125A61K 31/712
70
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Claims

Abstract

The present disclosure provides compositions comprising an antisense oligonucleotide and one or more excipients that modulates viscosity, turbidity or both viscosity and turbidity. In certain embodiments, compositions comprising an antisense oligonucleotide and one or more excipients having low viscosity are provided. In certain embodiments, compositions comprising an antisense oligonucleotide and one or more excipients having low turbidity are provided. In certain embodiments, pharmaceutical compositions comprising an antisense oligonucleotide and one or more excipients having low viscosity and turbidity are provided.

Claims

exact text as granted — not AI-modified
1 .- 275 . (canceled) 
     
     
         276 . An aqueous solution comprising:
 an antisense oligonucleotide; and   at least one excipient that modulates viscosity, turbidity or both viscosity and turbidity;   wherein the dynamic viscosity of the solution is less than 100 cP at 25° C.; and   wherein the antisense oligonucleotide is present at a concentration of 250 mg/ml to 500 mg/ml.   
     
     
         277 . The solution of  claim 276 , having a dynamic viscosity of less than 90 cP at 25° C. 
     
     
         278 . The solution of  claim 276 , having a dynamic viscosity of less than 80 cP at 25° C. 
     
     
         279 . The solution of  claim 276 , having a dynamic viscosity of less than 70 cP at 25° C. 
     
     
         280 . The solution of  claim 276 , having a dynamic viscosity of less than 60 cP at 25° C. 
     
     
         281 . The solution of  claim 276 , having a dynamic viscosity of less than 50 cP at 25° C. 
     
     
         282 . The solution of  claim 276 , having a dynamic viscosity of less than 40 cP at 25° C. 
     
     
         283 . The solution of  claim 276 , having a dynamic viscosity of less than 30 cP at 25° C. 
     
     
         284 . The solution of  claim 276 , having a dynamic viscosity of less than 20 cP at 25° C. 
     
     
         285 . The solution of  claim 276 , having a dynamic viscosity of less than 10 cP at 25° C. 
     
     
         286 . The solution of  claim 276 , having a turbidity of in the range of 0 to 4000 NTU. 
     
     
         287 . The solution of  claim 276 , having a turbidity of in the range of 0 to 3000 NTU. 
     
     
         288 . The solution of  claim 276 , having a turbidity of in the range of 0 to 2000 NTU. 
     
     
         289 . The solution of  claim 276 , having a turbidity of in the range of 0 to 1000 NTU. 
     
     
         290 . The solution of  claim 276 , having a turbidity of in the range of 0 to 100 NTU. 
     
     
         291 . The solution of  claim 276 , having a turbidity of in the range of 0 to 90 NTU. 
     
     
         292 . The solution of  claim 276 , having a turbidity of the solution is in the range of 0 to 80 NTU. 
     
     
         293 . The solution of  claim 276 , having a turbidity in the range of 0 to 70 NTU. 
     
     
         294 . The solution of  claim 276 , having a turbidity in the range of 0 to 60 NTU. 
     
     
         295 . The solution of  claim 276 , having a turbidity in the range of 0 to 50 NTU.

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