Super-oxide dismutase mimetics

Abstract

The present invention relates to compounds which are effective as catalysts for dismutating superoxide and, more particularly, the manganese or iron complexes of substituted, unsaturated heterocyclic 10-membered macrocyclic complexes that catalytically dismutate superoxide. It also relates to methods of using these complexes to reduce the concentration or the effects of superoxide, pharmaceutical compositions comprising these compounds or their metal complexes, and methods of treating conditions associated with excessive superoxide activity.

1 . A compound of formula (2b): 
       
         
           
           
               
               
           
         
         wherein R 1 , R 2 , m, n, p and M are as defined for formula (1) herein, and R 4  represents one or two optional substituents which may be present at any position(s) on the pyridine ring.