Parenteral formulations for administering macrolide antibiotics

Abstract

Pharmaceutical compositions adapted for the parenteral administration, including intravenous administration, of triazole containing macrolide antibiotics, and methods for their use in the treatment of bacterial, protozoal, and other infections are described herein.

1 . A pharmaceutical composition adapted for parenteral administration comprising one or more antibiotic compounds and a formulating agent, wherein the formulating agent is selected from the group consisting of lactic acid, an amino acid, and combinations thereof, and pharmaceutically acceptable salts of the foregoing; and where the one or more antibiotic compounds are of the formula 
       
         
           
           
               
               
           
         
       
       and pharmaceutically acceptable salts thereof, wherein:
 R 10  is hydrogen, acyl or a prodrug moiety; 
 W is H, F, Cl, Br, I, or OH; 
 A is CH 2 , C(O), C(O)O, C(O)NH, S(O) 2 , S(O) 2 NH, or C(O)NHS(O) 2 ; 
 B is C 2 -C 10  alkenylene or C 1 -C 10  alkylene; and 
 C is hydrogen, hydroxy, acyl, acyloxy, sulfonyl, ureido, or carbamoyl, or alkyl, alkoxy, heteroalkyl, heteroalkoxy, aryl, arylalkyl, heteroaryl, or heteroarylalkyl, each of which is optionally substituted. 
 
     
     
         2 .- 39 . (canceled)