Magnesium chloride composition for dermatological use

Abstract

Provided herein is a topical composition and related methods for making and using the composition. In a first aspect, the topical composition comprises a magnesium salt (e.g. magnesium chloride) dissolved in an anhydrous or non-aqueous solvent. Exemplary solvents comprise a monohydric aliphatic alcohol, and a polyol.

It is claimed: 
     
         1 . A topical composition, comprising:
 a magnesium salt and a non-aqueous solvent system comprised of a monohydric aliphatic alcohol and a polyol, wherein the composition does not comprise a tetracycline-class drug, wherein the monohydric aliphatic alcohol and the polyol are in a ratio of from about 1:1 to 99:1.   
     
     
         2 . The composition of  claim 1 , wherein the monohydric aliphatic alcohol is present in the composition at a greater percent by weight than the polyol. 
     
     
         3 . The composition of  claim 1 , wherein the monohydric aliphatic alcohol to polyol ratio is between about 2:1 to 10:1. 
     
     
         4 . The composition of  claim 1 , wherein the monohydric aliphatic alcohol is selected from the group consisting of ethanol, isopropanol, propyl alcohol, tert-butyl alcohol, and combinations thereof. 
     
     
         5 . The composition of  claim 1 , wherein the monohydric aliphatic alcohol is a liquid at room temperature, the polyol is a liquid at room temperature, or both the monohydric aliphatic alcohol and the polyol are liquids at room temperature. 
     
     
         6 . The composition of  claim 1 , wherein the polyol is a C3-C8 diol or triol. 
     
     
         7 . The composition of  claim 1 , wherein the polyol is propylene glycol. 
     
     
         8 . The composition of  claim 1 , wherein the magnesium salt is selected from the group consisting of magnesium chloride, magnesium sulfate, magnesium salicylate, and combinations thereof. 
     
     
         9 . The composition of  claim 1 , wherein the magnesium salt is selected from the group consisting of the anhydrous magnesium chloride, anhydrous magnesium sulfate, anhydrous magnesium salicylate, and combinations thereof. 
     
     
         10 . The composition  claim 1 , comprising between about 0.1% to about 10% by weight magnesium salt. 
     
     
         11 . The composition of  claim 10 , wherein the magnesium salt is magnesium chloride. 
     
     
         12 . The composition of  claim 1 , further comprising an essential oil. 
     
     
         13 . The composition of  claim 13 , wherein the essential oil is 1,8-cineole. 
     
     
         14 . The composition of  claim 13 , comprising between about 0.01 to 5 weight percent of 1,8-cineole. 
     
     
         15 . The composition of  claim 1 , further comprising a thickening agent. 
     
     
         16 . The composition of  claim 15 , wherein the thickening agent is hydroxypropyl cellulose. 
     
     
         17 . The composition of  claim 1 , wherein the magnesium salt is dissolved in the composition. 
     
     
         18 . The composition of  claim 1 , wherein the composition comprises less than about 3 weight percent water. 
     
     
         19 . A method for treating a dermatological condition or disease, comprising:
 topically applying to an exterior epithelial surface of a human body a composition according to  claim 1  at least once daily for a period of at least one week.   
     
     
         20 . A method for treating acne in a human subject, comprising topically applying to a local skin region affected by acne a composition according to  claim 1  at least once daily for a period of at least one week.