Milled bone graft materials and methods of use

Abstract

A bone material for hydration with a liquid is provided, the bone material comprising a coherent mass of milled and demineralized bone fibers, the coherent mass having no binder disposed in or on the coherent mass. In some embodiments, a bone material for hydration with a liquid is provided, the bone material comprising a coherent mass of cartridge milled, lyophilized and demineralized bone fibers, the coherent mass having no binder on the coherent mass. In some embodiments, a method of implanting a bone material is provided, the method comprising contacting the bone material with a liquid, the bone material comprising a coherent mass of cartridge milled, lyophilized and demineralized bone fibers, the coherent mass having no binder disposed in or on the coherent mass; molding the bone material into a shape to implant the bone material; and implanting the bone material at the target tissue site.

1 . A bone material for hydration with a liquid, the bone material comprising a coherent mass of milled and demineralized bone fibers, the milled and demineralized bone fibers physically entangled in the coherent mass. 
     
     
         2 . A bone material according to  claim 1 , wherein the bone material is lyophilized. 
     
     
         3 . A bone material according to  claim 1 , wherein the milled and demineralized bone fibers are cartridge milled and have a ribbon-like shape with increased surface area compared to demineralized bone powder. 
     
     
         4 . A bone material of  claim 2 , wherein the coherent mass of milled and lyophilized demineralized bone fibers are cartridge milled fibers having a ribbon-like shape, increased surface area and a curled portion. 
     
     
         5 . A bone material of  claim 2 , wherein the coherent mass of milled and lyophilized demineralized bone fibers comprise autograft or allograft bone. 
     
     
         6 . A bone material of  claim 1 , wherein the bone fibers have a diameter from about 100 μm to about 2 mm. 
     
     
         7 . A bone material of  claim 1 , wherein the bone fibers have a length from about 0.5 mm to about 50 mm. 
     
     
         8 . A bone material of  claim 1 , wherein the bone fibers have a length from about 0.5 cm to about 10 cm. 
     
     
         9 . A bone material of  claim 1 , wherein the fibers have an aspect ratio of from about 50:1 to about 1000:1, from about 50:1 to about 950:1, from about 50:1 to about 750:1, from about 50:1 to about 500:1, from about 50:1 to about 250:1, from about 50:1 to about 100:1, from about 10:1 to about 50:1, or from about 5:1 to about 10:1. 
     
     
         10 . A bone material of  claim 1 , wherein the liquid comprises blood, water, saline or a combination thereof. 
     
     
         11 . A bone material of  claim 1 , wherein the liquid is mixed with the coherent mass of milled and demineralized bone fibers that are lyophilized without a binder to form moldable lyophilized demineralized bone fibers. 
     
     
         12 . A bone material for hydration with a liquid, the bone material comprising a coherent mass of cartridge milled, lyophilized and demineralized bone fibers, the coherent mass of milled, lyophilized and demineralized bone fibers physically entangled in the coherent mass. 
     
     
         13 . A bone material of  claim 12 , wherein the coherent mass of cartridge milled and lyophilized demineralized bone fibers have a ribbon-like shape and increased surface area compared to demineralized bone powder. 
     
     
         14 . A bone material of  claim 13 , wherein the coherent mass of cartridge milled and lyophilized demineralized bone fibers comprise autograft or allograft bone. 
     
     
         15 . A bone material of  claim 13 , wherein the fibers have an aspect ratio of from about 50:1 to about 1000:1, from about 50:1 to about 950:1, from about 50:1 to about 750:1, from about 50:1 to about 500:1, from about 50:1 to about 250:1, from about 50:1 to about 100:1, from about 10:1 to about 50:1, or from about 5:1 to about 10:1. 
     
     
         16 . A bone material of  claim 13 , wherein the liquid is mixed with the coherent mass of cartridge milled and demineralized bone fibers that are lyophilized without a binder to form moldable lyophilized demineralized bone fibers. 
     
     
         17 - 19 . (canceled) 
     
     
         20 . A bone material of  claim 1 , wherein the coherent mass is in a disc shape. 
     
     
         21 . A bone material of  claim 1 , wherein the coherent mass is in a square shape. 
     
     
         22 . A bone material of  claim 1 , wherein the coherent mass has no binder disposed in or on the coherent mass.