Dietary supplement compositions with enhanced delivery matrix, gummies, chocolates, atomizers and powders containing same, and methods of making same

Abstract

A dietary supplement composition having a dispersion including a plurality of liposomal vesicles, includes an active ingredient, phospholipid contained in the liposomal vesicles, and a coating material. The active ingredient is incorporated within the liposomal vesicles having a barrier coating of the coating material including one of a biopolymer, polyethylene glycol, chitosan and a combination thereof. The coating material is free flowing in the dispersion such that the liposomal vesicles are surrounded by the coating material without being attached to the liposomal vesicles and without forming part of the liposomal vesicles and without affecting weight of the liposomal vesicles. The dispersion is filtered using a tangential flow technique, which washes out outer periphery of liposomal vesicles for removing inactive ingredients contained outside the liposomal vesicles without washing out the coating material surrounding the liposomal vesicles. The dietary supplement composition may be incorporated in gummies, chocolates, atomizers or powders.

What is claimed is: 
     
         1 . A dietary supplement composition having a dispersion including a plurality of liposomal vesicles, said dietary supplement composition comprising
 an active ingredient comprising one or more nutrients;   phospholipid contained in said liposomal vesicles; and   a coating material;   wherein said active ingredient is incorporated within said liposomal vesicles;   wherein the coating material is free flowing in said dispersion such that said liposomal vesicles are surrounded by said coating material without being attached to said liposomal vesicles and without forming part of said liposomal vesicles and without affecting weight of liposomal vesicles; and   wherein said dispersion is filtered using a tangential flow technique, which washes out outer periphery of liposomal vesicles so as to remove inactive ingredients contained outside the liposomal vesicles without washing out the coating material surrounding the liposomal vesicles.   
     
     
         2 . A dietary supplement composition according  claim 1 , where said active ingredient is one of curcumin, reduced glutathione, vitamin A, vitamin B 1  (thiamine), vitamin B 2  (riboflavin), vitamin B 3  (niacin), vitamin B 5  (pantothenic acid), vitamin B 6  (pyridoxine), vitamin B 7  (biotin), vitamin B 9  (folic acid), vitamin B 12  (cobalamin), vitamin C (ascorbic acid), vitamin D, vitamin E, vitamin K, trace mineral iron, trace mineral zinc, trace mineral iodine, trace mineral copper, trace mineral manganese, trace mineral fluoride, trace mineral chromium, trace mineral selenium, trace mineral molybdenum, and trace mineral boron, and a combination thereof. 
     
     
         3 . A dietary supplement composition according  claim 1 , further comprising cyclodextrin-a and cyclodextrin-c. 
     
     
         4 . A dietary supplement composition according  claim 1 , wherein said phospholipid comprises sunflower lecithin. 
     
     
         5 . A dietary supplement composition according  claim 1 , wherein said coating material is one of a biopolymer including saponin rich fraction obtained from fenugreek seeds, a polyethylene glycol identified with Registry Number 25322-68-3 in the Chemical Abstract Service of the American Chemical Society, chitosan, and a combination thereof. 
     
     
         6 . An gummy comprising dietary supplement composition of  claim 1 . 
     
     
         7 . An chocolate comprising dietary supplement composition of  claim 1 . 
     
     
         8 . An atomizer comprising dietary supplement composition of  claim 1 . 
     
     
         9 . An powder comprising dietary supplement composition of  claim 1 . 
     
     
         10 . A dietary supplement composition having a dispersion including a plurality of liposomal vesicles, said dietary supplement comprising
 an active ingredient comprising one or more nutrients; and   phospholipid contained in said liposomal vesicles, said phospholipid comprising sunflower lecithin;   wherein said active ingredient is incorporated within said liposomal vesicles; and   wherein said dispersion is filtered using a tangential flow technique, which washes out outer periphery of liposomal vesicles so as to remove inactive ingredient contained outside the liposomal vesicles.   
     
     
         11 . A dietary supplement composition according  claim 10 , where said active ingredient is one of curcumin, reduced glutathione, vitamin A, vitamin B 1  (thiamine), vitamin B 2  (riboflavin), vitamin B 3  (niacin), vitamin B 5  (pantothenic acid), vitamin B 6  (pyridoxine), vitamin B 7  (biotin), vitamin B 9  (folic acid), vitamin B 12  (cobalamin), vitamin C (ascorbic acid), vitamin D, vitamin E, vitamin K, trace mineral iron, trace mineral zinc, trace mineral iodine, trace mineral copper, trace mineral manganese, trace mineral fluoride, trace mineral chromium, trace mineral selenium, trace mineral molybdenum, and trace mineral boron, and a combination thereof. 
     
     
         12 . A dietary supplement composition according  claim 10 , wherein said phospholipid comprises sunflower lecithin. 
     
     
         13 . A gummy comprising dietary supplement composition of  claim 10 . 
     
     
         14 . An chocolate comprising dietary supplement composition of  claim 10 . 
     
     
         15 . An atomizer comprising dietary supplement composition of  claim 10 . 
     
     
         16 . A gummy comprising
 an inner portion; and   an outer portion which surrounds said inner portion;   wherein said inner portion comprises a dietary supplement composition having a dispersion including a plurality of liposomal vesicles,   said dietary supplement composition comprising
 an active ingredient comprising one or more nutrients; 
 phospholipid contained in said liposomal vesicles; and 
 a coating material; 
 wherein said active ingredient is incorporated within said liposomal vesicles; 
 wherein the coating material is free flowing in said dispersion such that said liposomal vesicles are surrounded by said coating material without being attached to said liposomal vesicles and without forming part of said liposomal vesicles and without affecting weight of liposomal vesicles; and 
 wherein said outer portion is formed of an edible material including one of fruit pectin, gelatin, cocoa, and a combination thereof, and comprises the active ingredient. 
   
     
     
         17 . A gummy according to  claim 16 , wherein the inner portion has a volume of about 1 milliliter which accommodates up to 300 mg of said active ingredient comprising one of curcumin, reduced glutathione, vitamin A, vitamin B 1  (thiamine), vitamin B 2  (riboflavin), vitamin B 3  (niacin), vitamin B 5  (pantothenic acid), vitamin B 6  (pyridoxine), vitamin B 7  (biotin), vitamin B 9  (folic acid), vitamin B 12  (cobalamin), vitamin C (ascorbic acid), vitamin D, vitamin E, vitamin K, trace mineral iron, trace mineral zinc, trace mineral iodine, trace mineral copper, trace mineral manganese, trace mineral fluoride, trace mineral chromium, trace mineral selenium, trace mineral molybdenum, and trace mineral boron, and a combination thereof. 
     
     
         18 . A gummy according to  claim 16 , further comprising cyclodextrin-a and cyclodextrin-c. 
     
     
         19 . A gummy according to  claim 16 , wherein said coating material is one of a biopolymer including saponin rich fraction obtained from fenugreek seeds, a polyethylene glycol identified with Registry Number 25322-68-3 in the Chemical Abstract Service of the American Chemical Society, chitosan, and a combination thereof. 
     
     
         20 . A gummy according to  claim 16 , wherein said inner portion has a volume of 1-5 ml.