Acellular tissue matrix compositions for tissue repair

Abstract

The invention provides tissue repair compositions and methods of making the tissue repair compositions. Also featured are methods of treatment using the tissue repair compositions and articles of manufacture that include the tissue repair compositions.

What is claimed is: 
     
         1 . A method of treatment, comprising:
 selecting a biocompatible mesh composition, comprising:
 a polypropylene sheet substrate; and 
 a biocompatible coating surrounding the sheet substrate, wherein the coating comprises a dried group of particulate acellular tissue matrix (ATM) particles, wherein the ATM particles comprise acid-swollen intact ATM that retains biological functions provided by undenatured collagenous proteins and non-collagenous molecules; 
   selecting an anatomical site; and   implanting the mesh composition at the anatomical site.   
     
     
         2 . The method of  claim 1 , wherein the anatomical site comprises a hernia site. 
     
     
         3 . The method of  claim 1 , wherein the anatomical site comprises an abdominal wall defect. 
     
     
         4 . The method of  claim 1 , wherein the ATM comprises dermal ATM. 
     
     
         5 . The method of  claim 1 , wherein the ATM comprises ATM derived from at least one of fascia, pericardial tissue, dura, umbilical cord tissue, placental tissue, cardiac valve tissue, ligament tissue, tendon tissue, arterial tissue, venous tissue, neural connective tissue, urinary bladder tissue, ureter tissue, and intestinal tissue. 
     
     
         6 . The method of  claim 1 , wherein the ATM is derived from human tissue. 
     
     
         7 . The method of  claim 1 , wherein the ATM is derived from non-human mammalian tissue. 
     
     
         8 . The method of  claim 7 , wherein the non-human mammalian tissue is porcine. 
     
     
         9 . The method of  claim 7 , wherein the tissue is from a non-human mammal that is genetically engineered to lack expression of α-1,3-galactosyl epitopes. 
     
     
         10 . The method of  claim 9 , wherein the non-human mammal lacks a functional α-1,3-galactosyltransferase gene. 
     
     
         11 . The method of  claim 1 , wherein the polypropylene sheet is a mesh. 
     
     
         12 . The method of  claim 11 , wherein the polypropylene sheet comprises polypropylene monofilament.