Methods and systems for shaping the radiation distribution profile of a protected radiation source used for treating medical conditions

Abstract

A method and system may include a therapeutic agent having a radioactive source enclosed by a container. The container may be placed within a cavity of a medical device for treating animal tissue. The method and system allows a radioactive source to be manufactured in such a manner so as to control and spatially modulate the delivery of radiation doses to a treatment area of animal tissue, such as for tissue of humans. From the container, radiation doses and/or a radiation field are produced by the radiation source. The geometry and size of the radiation doses are controlled by the geometry of the container and the geometry of the radiation source as well as the type, number, and geometry of holes/slots in either the source material and/or a surface of the container.

What is claimed is: 
     
         1 . A system for providing a radiation source producing a radiation field, the system comprising:
 a radioactive source with a first geometry and first perimeter defining its first geometry, the radioactive source having material generally spanning an area bounded by the first perimeter, the radioactive source having a first thickness dimension and a first width dimension; and   a container for enveloping the radioactive source, the container having a second thickness dimension and a second width dimension, the second thickness dimension being greater than the first thickness dimension, the second width dimension being greater than the first width dimension.   
     
     
         2 . The system of  claim 1 , wherein the radioactive source comprises at least one of:  9 Sr,  169 Yb,  90 Y,  192 Ir,  103 Pd,  177 Lu,  149 Pm,  140 La,  153 Sm,  186 Re,  188 Re,  166 Ho,  166 Dy,  137 Cs,  57 Co,  169 Er,  165 Dy,  97 Ru,  193m Pt,  195m Pt,  105 Rh,  68 Ni,  67 C,  64 Cu,  109 Cd,  111 Ag,  198 Au,  199 Au,  201 Ti,  175 Yb,  47 Sc,  159 Gd, and  212 Bi. 
     
     
         3 . The system of  claim 1 , wherein the first geometry comprises a disc, and wherein the container comprises a cylindrical geometry. 
     
     
         4 . The system of  claim 1 , wherein the first geometry comprises an irregular geometry and wherein the container comprises a cylindrical geometry. 
     
     
         5 . The system of  claim 1 , wherein the radioactive source comprises a third thickness dimension different from the first thickness dimension and less than the second thickness dimension. 
     
     
         6 . The systemof  claim 1 , wherein the radioactive source comprises apertures. 
     
     
         7 . The system of  claim 5 , wherein the apertures comprise at least one of circular holes and slots. 
     
     
         8 . The system of  claim 1 , wherein the container comprises a base and a lid. 
     
     
         9 . The system of  claim 1 , wherein the radioactive source comprises a cross-section having an irregular geometry, wherein the radioactive source is formed by three dimensional printing. 
     
     
         10 . The system of  claim 1 , wherein the radioactive source has a geometry that matches at least one of a tumor and an organ. 
     
     
         11 . A system for providing a radiation source producing a radiation field, the system comprising:
 a radioactive source with a first geometry and first perimeter defining its first geometry, the radioactive source having material generally spanning an area bounded by the first perimeter, the radioactive source having a first thickness dimension, and a second thickness dimension, and a first width dimension; the radioactive source having a thickness that varies across the area and has a magnitude between the first thickness dimension and the second thickness dimension; and   a container for enveloping the radioactive source, the container having a third thickness dimension and a second width dimension, the third thickness dimension being greater than the first and second thickness dimensions, the second width dimension being greater than the first width dimension, wherein the first geometry of the radioactive source comprises an irregular geometry and wherein the container comprises a cylindrical geometry.   
     
     
         12 . The system of  claim 11 , wherein the radioactive source comprises at least one of:  9 Sr,  169 Yb,  90 Y,  192 Ir,  103 Pd,  177 Lu,  149 Pm,  140 La,  153 Sm,  186 Re,  188 Re,  166 Ho,  166 Dy,  137 Cs,  57 Co,  169 Er,  165 Dy,  97 Ru,  193m Pt,  195m Pt,  105 Rh,  68 Ni,  67 C,  64 Cu,  109 Cd,  111 Ag,  198 Au,  199 Au,  201 Ti,  175 Yb,  47 Sc,  159 Gd, and  212 Bi. 
     
     
         13 . The system of  claim 11 , wherein the first geometry has fewer or no lines of symmetry relative to lines of symmetry for the container. 
     
     
         14 . The system of  claim 11 , wherein the radioactive source comprises apertures. 
     
     
         15 . The system of  claim 14 , wherein the apertures comprise at least one of circular holes and slots. 
     
     
         16 . The system of  claim 11 , wherein the container comprises a base and a lid. 
     
     
         17 . The system of  claim 11 , wherein the radioactive source is formed by three dimensional printing. 
     
     
         18 . The system of  claim 11 , further comprising a medical device, the medical device comprising a cavity in which the container is positioned. 
     
     
         19 . The system of  claim 18 , wherein the medical device is a hand-held device, 
     
     
         20 . The system of  claim 19 , wherein the hand-held device comprises a wand and a handle used in brachytherapy.