Methods and devices for endovascular embolization

Abstract

The present disclosure describes an occlusion device and methods of delivering the occlusion device. The occlusion device can include an expandable structure configured to move between an unexpanded configuration and an expanded configuration. The expandable structure can be configured to have an expansion ratio of at least about 5:1. Further, the occlusion device can be configured to prevent substantially all fluid from flowing past the occlusion device when the occlusion device is in the expanded configuration in the vessel.

1 .- 87 . (canceled) 
     
     
         88 . An endovascular occlusion device for occluding blood flow in a vessel, comprising:
 a support structure, self-expandable from a reduced cross section for transluminal navigation to an enlarged cross section for total vessel occlusion;   the support structure defining a concave occlusion component and an anchoring component separated by a neck portion, a maximum expanded diameter of the concave occlusion component is at an open end of the concave occlusion component, the concave occlusion component comprising an occlusive membrane carried by the support structure;   wherein the support structure is configured such that blood pressure against the concave occlusion component provides a radially outwardly directed force to seal the occlusion component against the vessel wall and an axially directed force against the neck which increases a radial force between the anchoring component and the vessel wall,   wherein when expanded, the occlusion device has bilateral asymmetry across a transverse plane extending through the concave occlusion component and the anchoring component.   
     
     
         89 . An endovascular occlusion device as in  claim 88 , wherein the support structure has an expansion ratio of at least about 6:1. 
     
     
         90 . An endovascular occlusion device as in  claim 88 , wherein the support structure has an expansion ratio of at least about 8:1. 
     
     
         91 . An endovascular occlusion device as in  claim 88 , comprising a guidewire lumen extending through the neck portion. 
     
     
         92 . An endovascular occlusion device as in  claim 91 , further comprising a valve for occluding the guidewire lumen. 
     
     
         93 . An endovascular occlusion device as in  claim 92 , wherein the valve comprises a collapsible tubular sleeve. 
     
     
         94 . An endovascular occlusion device as in  claim 93 , wherein the tubular sleeve is configured to collapse under arterial blood pressure following removal of a guidewire from the tubular sleeve. 
     
     
         95 . An endovascular occlusion device as in  claim 91 , configured for transluminal delivery over a 0.018 inch diameter guidewire. 
     
     
         96 . An endovascular occlusion device as in  claim 88 , wherein the membrane has an average thickness of no more than about 30 microns. 
     
     
         97 . An endovascular occlusion device as in  claim 88 , configured for deployment with the occlusion component concave in an upstream blood flow orientation, and the anchoring component is concave in a downstream direction. 
     
     
         98 . An endovascular occlusion device as in  claim 88 , wherein the support structure is expandable through a range of expansion sufficient to occlude blood vessels having inside diameters anywhere within the range from about 2.5 mm to about 8 mm. 
     
     
         99 . An endovascular occlusion device as in  claim 88 , wherein the reduced cross section is small enough that the occlusion device is deployable from a lumen having an inside diameter of no more than about 2 mm. 
     
     
         100 . An endovascular occlusion device as in  claim 88 , configured to achieve a total mechanical occlusion of blood flow following deployment in a blood vessel. 
     
     
         101 . An endovascular occlusion device as in  claim 88 , configured to achieve total occlusion within 5 minutes of deployment in a blood vessel. 
     
     
         102 . An endovascular occlusion device as in  claim 88 , wherein the neck portion is flexible so that the neck does not kink when the device is deployed in a curved vessel. 
     
     
         103 . An endovascular occlusion device as in  claim 88 , wherein the occlusion component has an axial length that is greater than an axial length of the anchoring component. 
     
     
         104 . The occlusion device of  claim 88 , wherein a proximal portion of the concave occlusion component has a generally uniform diameter, the proximal portion comprising the open end of the concave occlusion component. 
     
     
         105 . The occlusion device of  claim 88 , wherein a maximum expanded diameter of the anchoring component is at an open end of the anchoring component. 
     
     
         106 . The occlusion device of  claim 105 , wherein a distal portion of the anchoring component has a generally uniform diameter, the distal portion comprising the open end of the anchoring component. 
     
     
         107 . The occlusion device of  claim 88 , wherein the anchoring component is concave.