Minimum neuronal activation threshold transcranial magnetic stimulation at personalized resonant frequency

Abstract

A transcranial magnetic stimulation (TMS) treatment system is provided. The system includes a sensor device that senses EEG signals from a subject through one or more leads and a server device configured to receive EEG data corresponding to the subject. The server includes an analysis module configured to process the EEG data and determine a personalized resonant brain frequency and a minimum neuronal activation threshold of the subject based at least in part on EEG data corresponding to one or more leads of the sensor device. The analysis module is also configured to determine a TMS treatment protocol where the treatment protocol includes at least a frequency based on the personalized resonant brain frequency and an amplitude based on the minimum neuronal activation threshold. The system also includes a treatment device configured to deliver a TMS treatment to the subject based on the TMS treatment protocol received from the server.

What is claimed is: 
     
         1 . An electroencephalogram (EEG) evaluation system comprising:
 a headstrap configured to be secured to the head of a subject;   one or more sensor devices attached to the headstrap and positioned to sense an alpha brain wave of the subject and generate analog electroencephalogram (EEG) signals corresponding to the subject;   a user device communicatively coupled with the one or more sensor devices, the user device configured to receive the analog EEG signals corresponding to the subject from the one or more sensor devices, the user device further configured to process the analog EEG signals and generate a processed real time EEG signal, the user device further configured to further process the processed real time EEG signal to determine a real time brain frequency value based on an analysis of the processed real time EEG signal; and   the user device further configured to present on a display a real time brain frequency value graph based on the real time brain frequency value and continuously update the real time brain frequency value graph presented on the display in accordance with the received analog EEG signals.   
     
     
         2 . The system of  claim 1 , wherein the user device is one of a mobile computer, a tablet, a wireless communication device, a watch or a laptop. 
     
     
         3 . The system of  claim 1 , further comprising a transcranial magnetic stimulator attached to the headstrap and positioned to deliver a stimulus to the brain of the subject. 
     
     
         4 . The system of  claim 3 , wherein the transcranial magnetic stimulator is positioned to deliver a stimulus to an FZ location of the brain of the subject. 
     
     
         5 . The system of  claim 1 , further comprising a ground node configured to attach to the subject. 
     
     
         6 . The system of  claim 1 , wherein the user device is further configured to present on the display the personalized resonant brain frequency value. 
     
     
         7 . The system of  claim 6 , wherein the user device is further configured to continuously update the real time brain frequency value presented on the display in accordance with the received analog EEG signals. 
     
     
         8 . The system of  claim 1 , wherein the user device is further configured to further process the processed real time EEG signal to determine a minimum neuronal activation threshold value based on an analysis of the processed real time EEG signal. 
     
     
         9 . An electroencephalogram (EEG) evaluation system comprising:
 a sensor device configured to be secured to the head of a subject, the sensor device comprising one or more EEG sensors positioned to sense a brain wave of the subject and generate analog electroencephalogram (EEG) signals corresponding to the subject;   a user device communicatively coupled with the sensor device, the user device configured to
 receive the analog EEG signals corresponding to the subject from the sensor device, 
 process the analog EEG signals and generate a processed real time EEG signal, 
 determine a real time brain frequency value based on an analysis of at least the processed real time EEG signal, and 
 present on a display a real time brain frequency value graph based on the processed real time EEG signal and continuously update the real time brain frequency value graph presented on the display in accordance with continuously received analog EEG signals. 
   
     
     
         10 . The system of  claim 9 , wherein the user device is further configured to present on the display the real time brain frequency value and continuously update the real time brain frequency value presented on the display in accordance with continuously received analog EEG signals. 
     
     
         11 . The system of  claim 9 , wherein the user device is one of a mobile computer, a tablet, a wireless communication device, a watch or a laptop. 
     
     
         12 . The system of  claim 9 , wherein the sensor device further comprises a transcranial magnetic stimulator positioned to deliver a stimulus to the brain of the subject. 
     
     
         13 . The system of  claim 12 , wherein the transcranial magnetic stimulator is positioned to deliver a stimulus to an FZ location of the brain of the subject. 
     
     
         14 . The system of  claim 9 , wherein the sensor device further comprises a ground node configured to attach to the subject. 
     
     
         15 . The system of  claim 9 , wherein the user device is further configured to determine a minimum neuronal activation threshold value based on an analysis of at least the processed real time EEG signal. 
     
     
         16 . A system comprising:
 a strap configured to be secured to the head of a subject;   one or more sensor devices attached to the strap and positioned to sense a brain wave of the subject and generate electroencephalogram (EEG) data corresponding to the subject; and   a processor configured to receive the EEG data and analyze the EEG data to determine a personalized resonant brain frequency value of the brain of the subject based on the analysis.   
     
     
         17 . The system of  claim 16 , wherein the processor is further configured to present a current personalized resonant brain frequency value on a display of a device of the subject, wherein the device is one of a mobile computer, a tablet, a wireless communication device, a watch or a laptop. 
     
     
         18 . The system of  claim 16 , wherein the processor is further configured to receive an input from the subject and record a current personalized resonant brain frequency value of the subject in response to the input. 
     
     
         19 . The system of  claim 16 , wherein the processor is further configured to determine an average personalized resonant brain frequency value of the subject for one or more time periods and present the average personalized resonant brain frequency value on a display of a device of the subject, wherein the device is one of a mobile computer, a tablet, a wireless communication device, a watch or a laptop. 
     
     
         20 . The system of  claim 16 , wherein the processor is further configured to determine that a current personalized resonant brain frequency value of the subject is within a predetermined range and in response to said determination, provide a notice to the subject via a device of the subject.