Novel Compound Hexadecaphlorethol Isolated From Ishige Okamurae And Use Thereof

Abstract

Disclosed herein are hexadecaphlorethol (HdP), which is a novel compound isolated from Ishige okamurae, and the use thereof in anti-diabetic treatment and exercise performance improvement. The novel compound HdP has the activity of inhibiting α-glucosidase, inducing glucose uptake into differentiated myoblast C2C12 cells, reducing blood glucose levels in zebrafish which have reduced insulin secretion through treatment with alloxan, increasing an intracellular level of calcium ions necessary for muscle contraction and exercise performance in zebrafish, and inducing uptake of glucose, an energy source necessary for muscle contraction, into cells.

What is claimed is: 
     
         1 . A compound of Chemical Formula 1, a hydrate thereof, or a solvate thereof: 
       
         
           
           
               
               
           
         
       
     
     
         2 . The composition comprising the compound of  claim 1  and an excipient. 
     
     
         3 . The composition of  claim 2 , which is in a form of a food composition. 
     
     
         4 . The composition of  claim 2 , which is in a form of a pharmaceutical composition. 
     
     
         5 . A method for improving exercise performance ability, the method comprising:
 administering to a patient in need thereof a therapeutically effective amount of the composition of  claim 2 .   
     
     
         6 . The method of  claim 5 , wherein the composition is in a form of a food composition. 
     
     
         7 . The method of  claim 5 , wherein the composition is in a form of a pharmaceutical composition.