Treatments for migraine and related disorders

Abstract

Embodiments are directed to compositions and methods of treating migraine and related neurological disorders. In certain aspects, methods and compositions are for reducing cortical spreading depression and/or suppressing the neurochemical basis for chronic and acute migraine events, and provide methods and pharmaceutical compositions related to both acute and preventive therapies for migraine events and related headaches.

1 .- 46 . (canceled) 
     
     
         47 . A method for reducing spreading depression (SD) susceptibility in a patient in need thereof comprising administering to the patient an effective amount of a composition comprising insulin growth factor-1 (IGF-1), wherein reducing spreading depression excludes administering a cytokine to the patient. 
     
     
         48 . The method of  claim 52 , wherein the composition is administered intranasally. 
     
     
         49 . The method of  claim 52 , wherein the composition is administered multiple times. 
     
     
         50 . The method of  claim 52 , wherein the composition is administered on multiple days. 
     
     
         51 . The method of  claim 52 , wherein the composition is administered on multiple consecutive days. 
     
     
         52 . The method of  claim 52 , wherein the patient needs protection from demyelination. 
     
     
         53 . A method for reducing spreading depression (SD) susceptibility in a patient needing protection from demyelination comprising intranasally administering multiple times on multiple days to the patient a composition comprising insulin growth factor-1 (IGF-1), wherein reducing spreading depression excludes administering a cytokine to the patient.