Azetidinyloxyphenylpyrrolidine compounds

Abstract

The invention provides certain azetidinyloxyphenylpyrrolidine compounds, particularly compounds of formula I, and pharmaceutical compositions thereof. The invention further provides methods of using a compound of formula I to treat overactive bladder.

We claim: 
     
         1 . A compound of the formula 
       
         
           
           
               
               
           
         
         wherein 
         R is 
       
       
         
           
           
               
               
           
         
         R 1  is CH 3 , CN, Cl or CF 3 ; 
         or a pharmaceutically acceptable salt thereof; 
         provided when R 1  is CH 3  it is not attached at the 5 position. 
       
     
     
         2 . The compound or salt of  claim 1  of the formula 
       
         
           
           
               
               
           
         
         or a pharmaceutically acceptable salt thereof. 
       
     
     
         3 . The compound or salt of  claim 1  wherein R is 
       
         
           
           
               
               
           
         
       
     
     
         4 . The compound or salt of  claim 3  wherein R 1  is Cl. 
     
     
         5 . The compound or salt of  claim 1  or  2  wherein R is 
       
         
           
           
               
               
           
         
       
     
     
         6 . The compound which is (2S)-3-[(3S,4S)-3-[(1R)-1-hydroxyethyl]-4-(4-methoxy-3-{[1-(5-chloropyridin-2-yl)azetidin-3-yl]oxy}phenyl)-3-methylpyrrolidin-1-yl]-3-oxopropane-1,2-diol. 
     
     
         7 . A compound selected from the group consisting of: 
       
         
           
           
               
               
           
         
         
           
           
               
               
           
         
       
       or a pharmaceutically acceptable salt thereof. 
     
     
         8 . A pharmaceutical composition comprising a compound of  claim 6  or  7 , or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, diluent or excipient. 
     
     
         9 . A method of treating overactive bladder comprising administrating to a patient in need thereof an effective amount of a compound of  claim 6  or  7 , or a pharmaceutically acceptable salt thereof. 
     
     
         10 . A method of treating overactive bladder comprising administrating to a patient in need thereof an effective amount of a compound of  claim 6  or  7 , or a pharmaceutically acceptable salt thereof, in combination with an effective amount of tadalafil. 
     
     
         11 . (canceled) 
     
     
         12 . (canceled) 
     
     
         13 . (canceled)