Compositions and Methods for Injectable Composition for an Accommodating Intraocular Lens

Abstract

The present disclosure relates to injectable compositions and methods of making injectable compositions of moisture curing siloxane polymers for forming accommodating intraocular lenses. In certain embodiments, the moisture curing siloxane polymers are comprised of an organosilicon compound and a hydrolytically sensitive siloxane moiety and have a specific gravity of greater than about 0.95, a number average molecular weight (M n ) greater than about 5,000 or about 20,000 and a weight average molecular weight (M w ) greater than about 20,000 or about 40,000. The disclosure includes accommodating intraocular lenses formed from moisture curing siloxane polymers and having a modulus of elasticity of less than about 6 kPa, less than 20% post-cure extractables, refractive index ranging from 1.4 to 1.5 and dioptric range of accommodation of 0D to 10D.

1 . An injectable composition for forming an accommodating intraocular lens in situ in a capsule, comprising
 an organosilicon compound and   a hydrolytically sensitive siloxane moiety   wherein the injectable composition has a specific gravity greater than about 0.95, a number average molecular weight (M n ) greater than about 5,000, a weight average molecular weight (M w ) greater than about 20,000 and is capable of being substantially cured in situ upon contact with moisture.   
     
     
         2 . The injectable composition of  claim 1 , wherein the organosilicon compound comprises linear polysiloxane polymer chains, linear poly siloxane copolymer chains, branched polysiloxane polymer chains, or combinations thereof. 
     
     
         3 . The injectable composition of  claim 1 , wherein the injectable composition has a specific gravity in the range of 1 to 1.04. 
     
     
         4 . The injectable composition of  claim 1 , wherein the hydrolytically sensitive siloxane moiety comprises one or more of silane ether groups and/or one of more groups of silane ester groups. 
     
     
         5 . The injectable composition of  claim 1 , wherein the number average molecular weight (M n ) is in the range of about 5,000 to 150,000. 
     
     
         6 . The injectable composition of  claim 1 , wherein the weight average molecular weight (M w ) is in the range of about 20,000 to 300,000. 
     
     
         7 . The injectable composition of  claim 1 , wherein the injectable composition has mole fractions of the end groups that possess a hydrolysable moiety and cross linkable moiety in the range of greater than about 20%. 
     
     
         8 . The injectable composition of  claim 1 , wherein the injectable composition is substantially cured through condensation of one or more reactive silanol groups. 
     
     
         9 . The injectable composition of  claim 1 , wherein the injectable composition is capable of being substantially cured and the substantially cured composition has a refractive index in the range of about 1.41 to about 1.45. 
     
     
         10 . The injectable composition of  claim 1 , wherein the injectable composition is capable of being substantially cured and the substantially cured composition has a refractive index of at least 1.4. 
     
     
         11 . The injectable composition of  claim 1 , wherein the injectable composition is capable of being substantially cured and the substantially cured composition has a modulus of elasticity of about 0.1 to about 4 kPa. 
     
     
         12 . The injectable composition of  claim 1 , wherein the injectable composition is capable of being substantially cured and the substantially cured composition has a dioptric range of accommodation of 0 D to 10 D. 
     
     
         13 . A method of making an injectable composition for forming an accommodating intraocular lens in situ, comprising the step of mixing together
 an organosilicon compound and   a hydrolytically sensitive siloxane moiety   wherein the mixing together is performed using catalytic hydrosilation or condensation to form the injectable composition.   
     
     
         14 . An intraocular lens formed in situ by the steps comprising:
 a) injecting a composition comprising an organosilicon compound and a hydrolytically sensitive siloxane moiety into a capsule and   b) allowing the composition to cure upon contact with moisture, water or an aqueous medium to form the intraocular lens.   
     
     
         15 - 19 . (canceled)