US2020032219A1PendingUtilityA1

Herpes virus strains

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Assignee: BIOVEX LTDPriority: Jan 21, 2000Filed: Apr 5, 2019Published: Jan 30, 2020
Est. expiryJan 21, 2020(expired)· nominal 20-yr term from priority
Inventors:Robert Coffin
A61P 35/04A61P 37/04A61P 43/00A61P 31/00A61P 25/00A61P 25/28A61P 35/00A61P 25/02C12N 15/869C12N 7/00A61K 2039/55516C12N 2710/16643A61K 35/763C12N 15/86C12N 2710/16632A61K 2039/55522C12N 2710/16021A61K 48/00C12N 2710/16033
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Claims

Abstract

The present invention provides a herpes virus with improved oncolytic properties which comprises a gene encoding an immunomodulatory cytokine and which lacks a functional ICP34.5 gene and a functional ICP47 encoding gene.

Claims

exact text as granted — not AI-modified
1 . A herpes virus which comprises a gene encoding an immunomodulatory protein, which lacks a functional ICP34.5 encoding gene and a functional ICP47 encoding gene and which is replication competent in tumour cells. 
     
     
         2 - 43 . (canceled)

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