Analyte sensors having a signal-to-noise ratio substantially unaffected by non-constant noise

Abstract

Systems and methods of use involving sensors having a signal-to-noise ratio that is substantially unaffected by non-constant noise are provided for continuous analyte measurement in a host. In some embodiments, a continuous analyte measurement system is configured to be wholly, transcutaneously, intravascularly or extracorporeally implanted.

1 - 26 . (canceled) 
     
     
         27 . A transcutaneous electrochemical glucose sensor configured for implantation in a host, the transcutaneous electrochemical glucose sensor comprising:
 a first portion configured to remain outside a body of the host during sensor use; and   a second portion configured to be inserted inside the body of the host during sensor use, wherein the second portion comprises:
 a working electrode comprising a plurality of sensing regions; and 
 a reference electrode disposed at least in part on the second portion of the transcutaneous electrochemical glucose sensor. 
   
     
     
         28 . The transcutaneous electrochemical glucose sensor of  claim 27 , wherein the membrane comprises a layer configured to control a diffusion of glucose therethrough. 
     
     
         29 . The transcutaneous electrochemical glucose sensor of  claim 27 , wherein the layer comprises polyurethane. 
     
     
         30 . The transcutaneous electrochemical glucose sensor of  claim 27 , wherein the transcutaneous electrochemical glucose sensor has a planar shape. 
     
     
         31 . The transcutaneous electrochemical glucose sensor of  claim 27 , wherein the reference electrode further comprises silver and silver chloride. 
     
     
         32 . The transcutaneous electrochemical glucose sensor of  claim 27 , further comprising a counter electrode disposed at least in part on the second portion of the transcutaneous electrochemical glucose sensor. 
     
     
         33 . The transcutaneous electrochemical sensor of  claim 27 , wherein each of the plurality of sensing regions comprises a membrane. 
     
     
         34 . The transcutaneous electrochemical sensor of  claim 33 , wherein the membrane comprises an enzyme. 
     
     
         35 . The transcutaneous electrochemical sensor of  claim 33 , wherein the membrane is covered at least in part by a diffusion resistance domain.