Analyte sensors having a signal-to-noise ratio substantially unaffected by non-constant noise

Abstract

Systems and methods of use involving sensors having a signal-to-noise ratio that is substantially unaffected by non-constant noise are provided for continuous analyte measurement in a host. In some embodiments, a continuous analyte measurement system is configured to be wholly, transcutaneously, intravascularly or extracorporeally implanted.

1 - 20 . (canceled) 
     
     
         21 . A transcutaneous electrochemical glucose sensor configured for implantation in a host, the transcutaneous electrochemical glucose sensor comprising:
 a first portion configured to remain outside a body of the host during sensor use, wherein the first portion is configured to operably connect with sensor electronics; and   a second portion configured to be inserted inside the body of the host during sensor use, wherein the second portion comprises:
 a planar substrate; 
 a working electrode disposed over at least a portion of the planar substrate; 
 a membrane layer disposed over at least a portion of the working electrode; and 
 a reference electrode disposed at least in part on the second portion of the transcutaneous electrochemical glucose sensor, 
   
     
     
         22 . The transcutaneous electrochemical glucose sensor of  claim 21 , wherein the membrane layer is configured to control a diffusion of glucose therethrough. 
     
     
         23 . The transcutaneous electrochemical glucose sensor of  claim 21 , wherein the membrane layer comprises polyurethane. 
     
     
         24 . The transcutaneous electrochemical glucose sensor of  claim 21 , wherein the transcutaneous electrochemical glucose sensor has a planar shape. 
     
     
         25 . The transcutaneous electrochemical glucose sensor of  claim 21 , wherein the reference electrode comprises silver and silver chloride. 
     
     
         26 . The transcutaneous electrochemical glucose sensor of  claim 21 , further comprising a counter electrode disposed at least in part on the second portion of the transcutaneous electrochemical glucose sensor.