US2020048627A1PendingUtilityA1

Antigen-binding molecule capable of binding to two or more antigen molecules repeatedly

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Assignee: CHUGAI PHARMACEUTICAL CO LTDPriority: Apr 11, 2008Filed: Mar 22, 2019Published: Feb 13, 2020
Est. expiryApr 11, 2028(~1.7 yrs left)· nominal 20-yr term from priority
Inventors:Tomoyuki IgawaShinya IshiiAtsuhiko MaedaTakashi Nakai
A61P 37/00A61P 43/00C12N 2760/16134C12N 2760/16111C07K 16/244C07K 2317/622C07K 16/2866A61K 39/145C07K 2317/77C07K 2317/565C07K 2317/76C07K 2317/56C12N 15/1037A61K 39/12C07K 2317/24C07K 16/248A61K 2039/544A61K 2039/545A61K 2039/552G01N 2500/00G01N 33/6854A61K 2039/505C12N 2770/20071C07K 2317/92C07K 16/00
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Claims

Abstract

The present inventors discovered that antibodies having weaker antigen-binding activity at the early endosomal pH in comparison with that at the pH of plasma are capable of binding to multiple antigen molecules with a single antibody molecule, have long half-lives in plasma, and have improved durations of time in which they can bind to antigen.

Claims

exact text as granted — not AI-modified
1 - 50 . (canceled) 
     
     
         51 . An antibody that is capable of binding to human IL-6 and comprises
 (a) a heavy chain having the amino acid sequence of SEQ ID NO: 62 and a light chain having the amino acid sequence of SEQ ID NO: 63;   (b) a heavy chain having the amino acid sequence of SEQ ID NO: 64 and a light chain having the amino acid sequence of SEQ ID NO: 65; or   (c) a heavy chain having the amino acid sequence of SEQ ID NO: 64 and a light chain having the amino acid sequence of SEQ ID NO: 66.   
     
     
         52 . An antibody that is capable of binding to mouse IL-31 receptor and comprises
 (a) a heavy chain having the amino acid sequence of SEQ ID NO: 67 and a light chain having the amino acid sequence of SEQ ID NO: 68; or   (b) a heavy chain having the amino acid sequence of SEQ ID NO: 69 and a light chain having the amino acid sequence of SEQ ID NO: 68.

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