US2020054708A1PendingUtilityA1

Pharmaceutical composition for promoting neurogenesis and method of utilizing gastrodia elata extract or adenosine analog for promoting neurogenesis

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Assignee: UNIV CHINA MEDICALPriority: Aug 20, 2018Filed: Aug 20, 2019Published: Feb 20, 2020
Est. expiryAug 20, 2038(~12.1 yrs left)· nominal 20-yr term from priority
Inventors:Yun-Lian LinWei-Hsiang HsuYoung-Ji Shiao
A61K 36/8988A61K 31/7076A61P 25/00A61K 31/7034A61K 31/11A61K 31/05A61K 31/365A61P 25/28A61K 31/19A61K 31/115
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Claims

Abstract

The present invention relates to a composition and a method of utilizing Gastrodia elata extract or an adenosine analog to promote neurogenesis, wherein the G. elata extract includes gastrodin, gastrodigenin, parishins, N6-(4-hydroxybenzyl) adenosine (T1-11) and 4-hydroxybenzaldehyde. The G. elata extract of the present invention exhibits anti-aging activity on nerve cells and can induce neurogenesis in mouse hippocampus.

Claims

exact text as granted — not AI-modified
What is claimed is: 
     
         1 . A pharmaceutical composition for promoting neurogenesis, comprising:
 gastrodin, gastrodigenin, parishins, N 6 -(4-hydroxybenzyl) adenosine (T1-11) and 4-hydroxybenzaldehyde.   
     
     
         2 . The pharmaceutical composition for promoting neurogenesis according to  claim 1 , wherein the parishins comprises parishin A, parishin B, parishin C or parishin E. 
     
     
         3 . The pharmaceutical composition for promoting neurogenesis according to  claim 1 , wherein a weight percentage of N 6 -(4-hydroxybenzyl) adenosine is 0.5-4%. 
     
     
         4 . The pharmaceutical composition for promoting neurogenesis according to  claim 1 , wherein a weight percentage of gastrodin is greater than 25%. 
     
     
         5 . The pharmaceutical composition for promoting neurogenesis according to  claim 1 , wherein a weight percentage of parishins is greater than 50%. 
     
     
         6 . A method of utilizing  Gastrodia elata  extract for promoting neurogenesis, wherein the  G. elata  extract comprises gastrodin, gastrodigenin, parishin, N 6 -(4-hydroxybenzyl) adenosine (T1-11) and 4-hydroxybenzaldehyde. 
     
     
         7 . The method according to  claim 6 , wherein new born neurons are brain neurons. 
     
     
         8 . The method according to  claim 6 , wherein a weight percentage of N 6 -(4-hydroxybenzyl) adenosine is 0.5-4%, a weight percentage of gastrodin is greater than 25%, and a weight percentage of parishins is greater than 50%. 
     
     
         9 . A method of utilizing isolated N 6 -(4-hydroxybenzyl) adenosine (T1-11) or its pharmaceutical accepted salts for promoting neurogenesis. 
     
     
         10 . The method according to  claim 9 , wherein new born neurons are brain neurons.

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