Hydroxyapatite, cosmetic, food, and method for producing the same

Abstract

According to the present invention, provided is a carbonate- and magnesium-substituted hydroxyapatite having a particle size of 5 nm or more and 60 nm or less, wherein a portion of the calcium atoms in the hydroxyapatite are substituted with magnesium atoms and a portion of phosphate groups are substituted with carbonate groups.

What is claimed is: 
     
         1 . Carbonate- and magnesium-substituted hydroxyapatite having a part of calcium substituted with magnesium and a part of a phosphate group substituted with a carbonate group, and being composed of primary particles in a non-aggregated state, the primary particles having a particle size of 5 nm or more and 60 nm or less. 
     
     
         2 . The carbonate- and magnesium-substituted hydroxyapatite of  claim 1 , having the particle size of 10 nm or more and 50 nm or less. 
     
     
         3 . The carbonate- and magnesium-substituted hydroxyapatite of  claim 1 , present in a liquid. 
     
     
         4 . The carbonate- and magnesium-substituted hydroxyapatite of  claim 1 , having a chemical formula Ca 10-x Mg x (PO 4 ) 6-2/3y (CO 3 ) y (OH) 2 , where x is any value from 0.005 to 0.5, and y is any value from 0.01 to 3.0. 
     
     
         5 . The carbonate- and magnesium-substituted hydroxyapatite of  claim 1 , wherein calcium of the hydroxyapatite is substituted with 0.03 wt % or more and 5 wt % or less of magnesium with respect to calcium, and a part of the phosphate group is substituted with 0.2 wt % or more and 10 wt % or less of the carbonate group with respect to the phosphate group. 
     
     
         6 . A cosmetic containing the carbonate- and magnesium-substituted hydroxyapatite of  claim 1 . 
     
     
         7 . The cosmetic of  claim 6 , containing the carbonate- and the magnesium-substituted hydroxyapatite at a concentration of 0.001 wt % or more and 15 wt % or less. 
     
     
         8 . The cosmetic of  claim 6 , wherein
 the cosmetic is hair shampoo, rinse, conditioner, treatment, rinse-in shampoo, body shampoo, hand shampoo, facial cleansing foam, cleansing milky lotion, cleansing cream, cleansing oil, soap, liquid soap, liquid bath agent, lotion, cosmetic liquid, cosmetic oil, milky lotion, cream, gel, toothpaste powder, toothpaste, mouthwash, whitening liquid or deodorant.   
     
     
         9 . A food containing the carbonate- and magnesium-substituted hydroxyapatite of  claim 1 . 
     
     
         10 . The food of  claim 9 , containing the carbonate- and the magnesium-substituted hydroxyapatite at a concentration of 0.001 wt % or more and 15 wt % or less. 
     
     
         11 . The food of  claim 9 , wherein
 the food is a beverage, dairy product, edible oil, seasoning, ice cream, soup, cooked food, pet food or supplement.   
     
     
         12 . A method for producing carbonate- and magnesium-substituted hydroxyapatite having a part of calcium substituted with magnesium and a part of phosphate group substituted with a carbonate group, and being composed of primary particles in a non-aggregated state, the primary particles having a particle size of 5 nm or more and 60 nm or less,
 the method comprising:   preparing a mixed suspension containing magnesium hydroxide and calcium hydroxide;   preparing a phosphoric acid aqueous solution; and   mixing the mixed suspension and the phosphoric acid aqueous solution in the presence of carbon dioxide gas or carbonate, causing a neutralization reaction, and obtaining a suspension containing the carbonate- and magnesium-substituted hydroxyapatite composed of the primary particles in the non-aggregated state.   
     
     
         13 . A method for producing carbonate- and magnesium-substituted hydroxyapatite having a part of calcium substituted with magnesium and a part of phosphate group substituted with a carbonate group, and being composed of primary particles in a non-aggregated state, the primary particles having a particle size of 5 nm or more and 60 nm or less,
 the method comprising:   preparing a first solution containing magnesium salt and calcium salt;   preparing a second solution containing phosphate salt; and   mixing the first solution and the second solution in the presence of carbon dioxide gas or carbonate, causing a reaction, and obtaining a suspension containing the carbonate- and magnesium-substituted hydroxyapatite composed of the primary particles in the non-aggregated state.   
     
     
         14 . A method for producing a cosmetic containing carbonate- and magnesium-substituted hydroxyapatite having a portion of calcium substituted with magnesium and a portion of phosphate groups substituted with a carbonate group, and being composed of primary particles in a non-aggregated stated, the primary particles having a particle size of 5 nm or more and 60 nm or less,
 the method comprising:   obtaining a suspension containing the carbonate- and magnesium-substituted hydroxyapatite by the method of  claim 12 ; and   containing the suspension in the cosmetic.   
     
     
         15 . A method for producing a food containing carbonate- and magnesium-substituted hydroxyapatite having a portion of calcium substituted with magnesium and a portion of phosphate groups substituted with a carbonate group, and being composed of primary particles in a non-aggregated stated, the primary particles having a particle size of 5 nm or more and 60 nm or less,
 the method comprising:   obtaining a suspension containing the carbonate- and magnesium-substituted hydroxyapatite by the method of  claim 12 ; and   containing the suspension in the food.